Association of genetic variability in selected regions in
visfatin (NAMPT) gene with anthropometric parameters and
dietary composition in obese and non-obese Central-European
population

J 2013

Association of genetic variability in selected regions in visfatin (NAMPT) gene with anthropometric parameters and dietary composition in obese and non-obese Central-European population

ŠŤASTNÝ, Jiří, Julie BIENERTOVÁ VAŠKŮ, Josef TOMANDL, Marie TOMANDLOVÁ, Filip ZLÁMAL et. al.

Základní údaje

Originální název

Association of genetic variability in selected regions in visfatin (NAMPT) gene with anthropometric parameters and dietary composition in obese and non-obese Central-European population

Autoři

ŠŤASTNÝ, Jiří (203 Česká republika, domácí), Julie BIENERTOVÁ VAŠKŮ (203 Česká republika, garant, domácí), Josef TOMANDL (203 Česká republika, domácí), Marie TOMANDLOVÁ (203 Česká republika, domácí), Filip ZLÁMAL (203 Česká republika, domácí), Martin FOREJT (203 Česká republika, domácí), Zbyněk ŠPLÍCHAL (203 Česká republika, domácí) a Anna VAŠKŮ (203 Česká republika, domácí)

Vydání

Diabetes & metabolic syndrome, Amsterdam, Elsevier, 2013, 1871-4021

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30105 Physiology

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14110/13:00069379

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.dsx.2013.06.001

UT WoS

000215391200009

Klíčová slova anglicky

Anthropometric parameters; Dietary composition; Extreme obesity; NAMPT; SNP; Visfatin

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 23. 11. 2013 22:06, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Aims Visfatin (NAMPT/PBEF) is a recently identified adipocytokine which harbors strong insulin-mimetic activity and was reported to be associated with obesity. However, nothing is known about whether visfatin is related to specific nutritional behavior which may result in obesity development. This is the first study focusing on genetic variability of the visfatin gene and its association with circulating visfatin, anthropometric parameters and dietary composition. Materials and Methods We analyzed a total of 11 exons and adjacent non-coding regions of the NAMPT gene in 20 extremely obese Czech individuals (mean BMI 52.2 +/- 5.0 SD) using direct sequencing and a frequency of rs2302559 was established in the validation cohort of another 605 individuals with completed 7-day food records and complex anthropometric measurements. Serum levels of visfatin, leptin and leptin-receptor were measured in all sequenced individuals and in part of the validation cohort. Results Three common polymorphisms were identified, two in non-coding regions (rs78411774 A/C, rs71564769 A/C) and one synonymous SNP in exon 7 (rs2302559 A/G). The rs2302559 showed significant correlation with visfatin serum level throughout the entire study cohort (p < 0.001); there was a significant tendency toward higher visfatin levels in G allele carriers with GG homozygotes having the highest visfatin serum levels. Furthermore, a negative correlation was observed between visfatin and leptin serum level (p = 0.01). No association between investigated SNPs and anthropometric parameters or native dietary composition was observed. Conclusion This is the first study to demonstrate that the rs2302559 polymorphism in the PBEF gene is related to circulating levels of visfatin. As the SNP is synonymous, we hypothesize it might be linked to another SNP in the PBEF gene which controls visfatin serum levels.

Přiložené soubory

Association_of_genetic.pdf

Požádat o autorskou verzi souboru

Citovat

ŠŤASTNÝ, Jiří, Julie BIENERTOVÁ VAŠKŮ, Josef TOMANDL, Marie TOMANDLOVÁ, Filip ZLÁMAL, Martin FOREJT, Zbyněk ŠPLÍCHAL a Anna VAŠKŮ. Association of genetic variability in selected regions in visfatin (NAMPT) gene with anthropometric parameters and dietary composition in obese and non-obese Central-European population. Diabetes & metabolic syndrome. Amsterdam: Elsevier, 2013, roč. 7, č. 3, s. 166-171. ISSN 1871-4021. Dostupné z: https://dx.doi.org/10.1016/j.dsx.2013.06.001.

@article{1122868,
   author = {Šťastný, Jiří and Bienertová Vašků, Julie and Tomandl, Josef and Tomandlová, Marie and Zlámal, Filip and Forejt, Martin and Šplíchal, Zbyněk and Vašků, Anna},
   article_location = {Amsterdam},
   article_number = {3},
   doi = {http://dx.doi.org/10.1016/j.dsx.2013.06.001},
   keywords = {Anthropometric parameters; Dietary composition; Extreme obesity; NAMPT; SNP; Visfatin},
   language = {eng},
   issn = {1871-4021},
   journal = {Diabetes & metabolic syndrome},
   title = {Association of genetic variability in selected regions in visfatin (NAMPT) gene with anthropometric parameters and dietary composition in obese and non-obese Central-European population},
   volume = {7},
   year = {2013}
}

TY  - JOUR
ID  - 1122868
AU  - Šťastný, Jiří - Bienertová Vašků, Julie - Tomandl, Josef - Tomandlová, Marie - Zlámal, Filip - Forejt, Martin - Šplíchal, Zbyněk - Vašků, Anna
PY  - 2013
TI  - Association of genetic variability in selected regions in visfatin (NAMPT) gene with anthropometric parameters and dietary composition in obese and non-obese Central-European population
JF  - Diabetes & metabolic syndrome
VL  - 7
IS  - 3
SP  - 166-171
EP  - 166-171
PB  - Elsevier
SN  - 18714021
KW  - Anthropometric parameters
KW  - Dietary composition
KW  - Extreme obesity
KW  - NAMPT
KW  - SNP
KW  - Visfatin
N2  - Aims Visfatin (NAMPT/PBEF) is a recently identified adipocytokine which harbors strong insulin-mimetic activity and was reported to be associated with obesity. However, nothing is known about whether visfatin is related to specific nutritional behavior which may result in obesity development. This is the first study focusing on genetic variability of the visfatin gene and its association with circulating visfatin, anthropometric parameters and dietary composition. Materials and Methods We analyzed a total of 11 exons and adjacent non-coding regions of the NAMPT gene in 20 extremely obese Czech individuals (mean BMI 52.2 +/- 5.0 SD) using direct sequencing and a frequency of rs2302559 was established in the validation cohort of another 605 individuals with completed 7-day food records and complex anthropometric measurements. Serum levels of visfatin, leptin and leptin-receptor were measured in all sequenced individuals and in part of the validation cohort. Results Three common polymorphisms were identified, two in non-coding regions (rs78411774 A/C, rs71564769 A/C) and one synonymous SNP in exon 7 (rs2302559 A/G). The rs2302559 showed significant correlation with visfatin serum level throughout the entire study cohort (p < 0.001); there was a significant tendency toward higher visfatin levels in G allele carriers with GG homozygotes having the highest visfatin serum levels. Furthermore, a negative correlation was observed between visfatin and leptin serum level (p = 0.01). No association between investigated SNPs and anthropometric parameters or native dietary composition was observed. Conclusion This is the first study to demonstrate that the rs2302559 polymorphism in the PBEF gene is related to circulating levels of visfatin. As the SNP is synonymous, we hypothesize it might be linked to another SNP in the PBEF gene which controls visfatin serum levels.
ER  -

ŠŤASTNÝ, Jiří, Julie BIENERTOVÁ VAŠKŮ, Josef TOMANDL, Marie TOMANDLOVÁ, Filip ZLÁMAL, Martin FOREJT, Zbyněk ŠPLÍCHAL a Anna VAŠKŮ. Association of genetic variability in selected regions in visfatin (NAMPT) gene with anthropometric parameters and dietary composition in obese and non-obese Central-European population. \textit{Diabetes \&{} metabolic syndrome}. Amsterdam: Elsevier, 2013, roč.~7, č.~3, s.~166-171. ISSN~1871-4021. Dostupné z: https://dx.doi.org/10.1016/j.dsx.2013.06.001.

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