HRADILOVÁ SVÍŽENSKÁ, Ivana, Václav BRÁZDA, Ilona KLUSÁKOVÁ a Petr DUBOVÝ. Bilateral Changes of Cannabinoid Receptor Type 2 Protein and mRNA in the Dorsal Root Ganglia of a Rat Neuropathic Pain Model. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY. LONDON: SAGE PUBLICATIONS LTD, 2013, roč. 61, č. 7, s. 529-547. ISSN 0022-1554. Dostupné z: https://dx.doi.org/10.1369/0022155413491269. |
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@article{1124208, author = {Hradilová Svíženská, Ivana and Brázda, Václav and Klusáková, Ilona and Dubový, Petr}, article_location = {LONDON}, article_number = {7}, doi = {http://dx.doi.org/10.1369/0022155413491269}, keywords = {unilateral nerve injury; remote neuroinflammation; satellite glial cells}, language = {eng}, issn = {0022-1554}, journal = {JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY}, title = {Bilateral Changes of Cannabinoid Receptor Type 2 Protein and mRNA in the Dorsal Root Ganglia of a Rat Neuropathic Pain Model}, url = {http://www.ncbi.nlm.nih.gov/pubmed/23657829}, volume = {61}, year = {2013} }
TY - JOUR ID - 1124208 AU - Hradilová Svíženská, Ivana - Brázda, Václav - Klusáková, Ilona - Dubový, Petr PY - 2013 TI - Bilateral Changes of Cannabinoid Receptor Type 2 Protein and mRNA in the Dorsal Root Ganglia of a Rat Neuropathic Pain Model JF - JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY VL - 61 IS - 7 SP - 529-547 EP - 529-547 PB - SAGE PUBLICATIONS LTD SN - 00221554 KW - unilateral nerve injury KW - remote neuroinflammation KW - satellite glial cells UR - http://www.ncbi.nlm.nih.gov/pubmed/23657829 L2 - http://www.ncbi.nlm.nih.gov/pubmed/23657829 N2 - Cannabinoid receptor type 2 (CB2R) plays a critical role in nociception. In contrast to cannabinoid receptor type 1 ligands, CB2R agonists do not produce undesirable central nervous system effects and thus promise to treat neuropathic pain that is often resistant to medical therapy. In the study presented here, we evaluated the bilateral distribution of the CB2R protein and messenger RNA (mRNA) in rat dorsal root ganglia (DRG) after unilateral peripheral nerve injury using immunohistochemistry, western blot, and in situ hybridization analysis. Unilateral chronic constriction injury (CCI) of the sciatic nerve induced neuropathic pain behavior and bilateral elevation of both CB2R protein and mRNA in lumbar L4-L5 as well as cervical C7-C8 DRG when compared with naive animals. CB2R protein and mRNA were increased not only in DRG neurons but also in satellite glial cells. The fact that changes appear bilaterally and (albeit at a lower level) even in the remote cervical DRG can be related to propagation of neuroinflammation alongside the neuraxis and to the neuroprotective effects of CB2R. ER -
HRADILOVÁ SVÍŽENSKÁ, Ivana, Václav BRÁZDA, Ilona KLUSÁKOVÁ a Petr DUBOVÝ. Bilateral Changes of Cannabinoid Receptor Type 2 Protein and mRNA in the Dorsal Root Ganglia of a Rat Neuropathic Pain Model. \textit{JOURNAL OF HISTOCHEMISTRY \&{} CYTOCHEMISTRY}. LONDON: SAGE PUBLICATIONS LTD, 2013, roč.~61, č.~7, s.~529-547. ISSN~0022-1554. Dostupné z: https://dx.doi.org/10.1369/0022155413491269.
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