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@article{1126486,
author = {Filip, Pavel and Lungu, Ovidiu V. and Shaw, Daniel Joel and Kašpárek, Tomáš and Bareš, Martin},
article_location = {New York},
article_number = {Oct},
doi = {http://dx.doi.org/10.1155/2013/908741},
keywords = {cervical dystonia; cerebellar signs; basal ganglia},
language = {eng},
issn = {2090-5904},
journal = {Neural Plasticity},
title = {The Mechanisms of Movement Control and Time Estimation in Cervical Dystonia Patients},
url = {http://www.hindawi.com/journals/np/2013/908741/},
volume = {Neuveden},
year = {2013}
}
TY - JOUR
ID - 1126486
AU - Filip, Pavel - Lungu, Ovidiu V. - Shaw, Daniel Joel - Kašpárek, Tomáš - Bareš, Martin
PY - 2013
TI - The Mechanisms of Movement Control and Time Estimation in Cervical Dystonia Patients
JF - Neural Plasticity
VL - Neuveden
IS - Oct
SP - "nestránkováno"
EP - "nestránkováno"
PB - HINDAWI PUBLISHING CORPORATION
SN - 20905904
KW - cervical dystonia
KW - cerebellar signs
KW - basal ganglia
UR - http://www.hindawi.com/journals/np/2013/908741/
L2 - http://www.hindawi.com/journals/np/2013/908741/
N2 - Traditionally, the pathophysiology of cervical dystonia has been regarded mainly in relation to neurochemical abnormities in the basal ganglia. Recently, however, substantial evidence has emerged for cerebellar involvement. While the absence of neurological “cerebellar signs” in most dystonia patients may be considered at least provoking, there are more subtle indications of cerebellar dysfunction in complex, demanding tasks. Specifically, given the role of the cerebellum in the neural representation of time, in the millisecond range, dysfunction to this structure is considered to be of greater importance than dysfunction of the basal ganglia. In the current study,we investigated the performance of cervical dystonia patients on a computer task known to engage the cerebellum, namely, the interception of a moving target with changing parameters (speed, acceleration, and angle) with a simple response (pushing a button). The cervical dystonia patients achieved significantly worse results than a sample of healthy controls. Our results suggest that the cervical dystonia patients are impaired at integrating incoming visual information with motor responses during the prediction of upcoming actions, an impairment we interpret as evidence of cerebellar dysfunction.
ER -
FILIP, Pavel, Ovidiu V. LUNGU, Daniel Joel SHAW, Tomáš KAŠPÁREK a Martin BAREŠ. The Mechanisms of Movement Control and Time Estimation in Cervical Dystonia Patients. \textit{Neural Plasticity}. New York: HINDAWI PUBLISHING CORPORATION, 2013, Neuveden, Oct, s.~''nestránkováno'', 10 s. ISSN~2090-5904. Dostupné z: https://dx.doi.org/10.1155/2013/908741.
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