| KRALICKOVA, Pavlina, Eva MALA, Doris VOKURKOVA, Irena KRCMOVA, Lenka PLISKOVA, Vlasta STEPANOVA, Vladimir BARTOS, Vladimir KOBLIZEK, Ilja TACHECI, Jan BURES, Jan BROZIK a Jiří LITZMAN. Cytomegalovirus Disease in Patients with Common Variable Immunodeficiency: Three Case Reports. International archives of allergy and immunology. Basel: Karger, 2014, roč. 163, č. 1, s. 69-74. ISSN 1018-2438. Dostupné z: https://dx.doi.org/10.1159/000355957. |
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@article{1131918,
author = {Kralickova, Pavlina and Mala, Eva and Vokurkova, Doris and Krcmova, Irena and Pliskova, Lenka and Stepanova, Vlasta and Bartos, Vladimir and Koblizek, Vladimir and Tacheci, Ilja and Bures, Jan and Brozik, Jan and Litzman, Jiří},
article_location = {Basel},
article_number = {1},
doi = {http://dx.doi.org/10.1159/000355957},
keywords = {Common variable immunodeficiency; Cytomegalovirus; Mycobacteriosis; Opportunistic infection; Pneumonitis; Enteritis},
language = {eng},
issn = {1018-2438},
journal = {International archives of allergy and immunology},
title = {Cytomegalovirus Disease in Patients with Common Variable Immunodeficiency: Three Case Reports},
volume = {163},
year = {2014}
}
TY - JOUR
ID - 1131918
AU - Kralickova, Pavlina - Mala, Eva - Vokurkova, Doris - Krcmova, Irena - Pliskova, Lenka - Stepanova, Vlasta - Bartos, Vladimir - Koblizek, Vladimir - Tacheci, Ilja - Bures, Jan - Brozik, Jan - Litzman, Jiří
PY - 2014
TI - Cytomegalovirus Disease in Patients with Common Variable Immunodeficiency: Three Case Reports
JF - International archives of allergy and immunology
VL - 163
IS - 1
SP - 69-74
EP - 69-74
PB - Karger
SN - 10182438
KW - Common variable immunodeficiency
KW - Cytomegalovirus
KW - Mycobacteriosis
KW - Opportunistic infection
KW - Pneumonitis
KW - Enteritis
N2 - Common variable immunodeficiency (CVID) is the most frequent clinically relevant primary immunodeficiency and shows enormous heterogeneity in clinical presentation. Despite clinical immunodeficiency, opportunistic infections are not a typical manifestation of CVID. A retrospective study of 32 patients followed up for 335 patient-years was performed to determine the frequency of cytomegalovirus (CMV) disease. Symptomatic CMV infection was documented in 3 CVID patients. Patients No. 1 and 2 suffered from CMV pneumonia, with complications due to atypical mycobacteriosis in patient No. 1. Patient No. 3 suffered from CMV enteritis. A history of cancer and chronic hepatitis C infection (patient No. 1), immunosuppressive therapy for interstitial lung disease (patient No. 2) and serious enteropathy complicated with malnutrition (patient No. 3) may have contributed to the complications despite only mild abnormalities in T-cell subpopulations. The direct detection of CMV in bronchoalveolar lavage, stool or tissue samples was the most beneficial diagnostic laboratory method, whereas the detection of CMV DNA in blood did not produce positive results. Adequate treatment of CMV disease led to significant clinical improvement in all 3 patients. The frequency of CMV disease appears to be higher than previously described. In our experience, the probability of opportunistic infections in CVID patients increases with secondary comorbidities and their management.
ER -
KRALICKOVA, Pavlina, Eva MALA, Doris VOKURKOVA, Irena KRCMOVA, Lenka PLISKOVA, Vlasta STEPANOVA, Vladimir BARTOS, Vladimir KOBLIZEK, Ilja TACHECI, Jan BURES, Jan BROZIK a Jiří LITZMAN. Cytomegalovirus Disease in Patients with Common Variable Immunodeficiency: Three Case Reports. \textit{International archives of allergy and immunology}. Basel: Karger, 2014, roč.~163, č.~1, s.~69-74. ISSN~1018-2438. Dostupné z: https://dx.doi.org/10.1159/000355957.
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