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@article{1132095,
author = {Lassus, Johan and Gayat, Etienne and Mueller, Christian and Peacock, Frank W. and Špinar, Jindřich and Harjola, VeliandPekka and PascualandFigal, Domingo and Laribi, Said and Logeart, Damien and Nouira, Semir and Metra, Marco and Kimmenade, Roland von and Pathak, Atul and Mueller, Thomas and Somma, Salvatore di and Sato, Naoki and Potocki, Michael and Pařenica, Jiří and Collet, Corinne and CohenandSolal, Alain and Januzzi, James L. Jr. and Mebazaa, Alexandre},
article_location = {Clare},
article_number = {3},
doi = {http://dx.doi.org/10.1016/j.ijcard.2013.01.228},
keywords = {ADHF; Mortality; Risk prediction; Biomarkers; Reclassification},
language = {eng},
issn = {0167-5273},
journal = {International Journal of Cardiology},
title = {Incremental value of biomarkers to clinical variables for mortality prediction in acutely decompensated heart failure: The Multinational Observational Cohort on Acute Heart Failure (MOCA) study},
volume = {168},
year = {2013}
}
TY - JOUR
ID - 1132095
AU - Lassus, Johan - Gayat, Etienne - Mueller, Christian - Peacock, Frank W. - Špinar, Jindřich - Harjola, Veli-Pekka - Pascual-Figal, Domingo - Laribi, Said - Logeart, Damien - Nouira, Semir - Metra, Marco - Kimmenade, Roland von - Pathak, Atul - Mueller, Thomas - Somma, Salvatore di - Sato, Naoki - Potocki, Michael - Pařenica, Jiří - Collet, Corinne - Cohen-Solal, Alain - Januzzi, James L. Jr. - Mebazaa, Alexandre
PY - 2013
TI - Incremental value of biomarkers to clinical variables for mortality prediction in acutely decompensated heart failure: The Multinational Observational Cohort on Acute Heart Failure (MOCA) study
JF - International Journal of Cardiology
VL - 168
IS - 3
SP - 2186-2194
EP - 2186-2194
PB - ELSEVIER IRELAND LTD
SN - 01675273
KW - ADHF
KW - Mortality
KW - Risk prediction
KW - Biomarkers
KW - Reclassification
N2 - Aim: This study aims to evaluate the incremental value of plasma biomarkers to traditional clinical variables for risk stratification of 30-day and one-year mortality in acutely decompensated heart failure (ADHF). Methods and results: Through an international collaborative network, individual patient data on 5306 patients hospitalized for ADHF were collected. The all-cause mortality rate was 11.7% at 30 days and 32.9% at one year. The clinical prediction model (age, gender, blood pressure on admission, estimated glomerular filtration rate <60mL/min/1.73 m(2), sodium and hemoglobin levels, and heart rate) had a c-statistic of 0.74 for 30-day mortality and 0.73 for one-year mortality. Several biomarkers measured at presentation improved risk stratification when added to the clinical model. At 30 days, the net reclassification improvement (NRI) was 28.7% for mid-regional adrenomedullin (MR-proADM; p<0.001) and 25.5% for soluble (s) ST2 (p<.001). At one year, sST2 (NRI 10.3%), MR-proADM (NRI 9.1%), amino-terminal pro-B-type natriuretic peptide (NT-proBNP; NRI 9.1%), mid-regional proatrial natriuretic peptide (MR-proANP; NRI 7.4%), B-type natriuretic peptide (NRI 5.5%) and C-reactive protein (CRP; NRI 5.3%) reclassified patients with ADHF (p<0.05 for all). CRP also markedly improved risk stratification of patients with ADHF as a dual biomarker combination with MR-proADM (NRI 36.8% [p<0.001] for death at 30 days) or with sST2 (NRI 20.3%; [p<0.001] for one-year mortality). Conclusion: In this study, biomarkers provided incremental value for risk stratification of ADHF patients. Biomarkers such as sST2, MR-proADM, natriuretic peptides and CRP, reflecting different pathophysiologic pathways, add prognostic value to clinical risk factors for predicting both short-term and one-year mortality in ADHF.
ER -
LASSUS, Johan, Etienne GAYAT, Christian MUELLER, Frank W. PEACOCK, Jindřich ŠPINAR, Veli-Pekka HARJOLA, Domingo PASCUAL-FIGAL, Said LARIBI, Damien LOGEART, Semir NOUIRA, Marco METRA, Roland von KIMMENADE, Atul PATHAK, Thomas MUELLER, Salvatore di SOMMA, Naoki SATO, Michael POTOCKI, Jiří PAŘENICA, Corinne COLLET, Alain COHEN-SOLAL, James L. Jr. JANUZZI a Alexandre MEBAZAA. Incremental value of biomarkers to clinical variables for mortality prediction in acutely decompensated heart failure: The Multinational Observational Cohort on Acute Heart Failure (MOCA) study. \textit{International Journal of Cardiology}. Clare: ELSEVIER IRELAND LTD, 2013, roč.~168, č.~3, s.~2186-2194. ISSN~0167-5273. Dostupné z: https://dx.doi.org/10.1016/j.ijcard.2013.01.228.
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