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@article{1137488,
author = {Meluzín, Jaroslav and Tomandl, Josef and Podroužková, Helena and Gregorová, Zdeňka and Soška, Vladimír and Dobšák, Petr and Pecen, Ladislav and Stepanova, Radka},
article_location = {Olomouc},
article_number = {4},
doi = {http://dx.doi.org/10.5507/bp.2012.110},
keywords = {echocardiography; heart failure with normal ejection fraction; biomarkers},
language = {eng},
issn = {1213-8118},
journal = {Biomedical Papers of the Faculty of Medicine and Dentistry of Palacký University, Olomouc, Czech Republic},
title = {Can markers of collagen turnover or other biomarkers contribute to the diagnostics of heart failure with normal left ventricular ejection fraction?},
volume = {157},
year = {2013}
}
TY - JOUR
ID - 1137488
AU - Meluzín, Jaroslav - Tomandl, Josef - Podroužková, Helena - Gregorová, Zdeňka - Soška, Vladimír - Dobšák, Petr - Pecen, Ladislav - Stepanova, Radka
PY - 2013
TI - Can markers of collagen turnover or other biomarkers contribute to the diagnostics of heart failure with normal left ventricular ejection fraction?
JF - Biomedical Papers of the Faculty of Medicine and Dentistry of Palacký University, Olomouc, Czech Republic
VL - 157
IS - 4
SP - 331-339
EP - 331-339
PB - Palacký University
SN - 12138118
KW - echocardiography
KW - heart failure with normal ejection fraction
KW - biomarkers
N2 - Aims. Plasma levels of some biomarkers and markers of collagen turnover may reflect myocardial structural abnormalities associated with diastolic dysfunction. The aim of this study was to determine whether these markers could contribute to the diagnostics of heart failure with normal ejection fraction (HFNEF). Methods and Results. 91 patients with exertional dyspnea and normal left ventricular ejection fraction and 20 healthy controls underwent plasma analysis of markers of collagen turnover and other biomarkers, spirometry, and resting and exercise echocardiography. 38 patients with dyspnea had evidence of HFNEF, diagnosed at the early stage. Compared to the remaining patients, those with HFNEF had a significantly higher plasma levels of carboxy-terminal telopeptide of collagen type I (median 4.5 ug/L vs. 3.5 ug/L, P<0.05) and big endothelin (median 1.1 pmol/L vs 0.9 pmol/L, P<0.05). Univariate logistic regression analysis revealed a significant association between HFNEF and the following biomarkers: big endothelin, amino-terminal propeptide of type III procollagen (PIIINP), and matrix metalloproteinase-2 (MMP-2). However, none of these biomarkers independently contributed to the HFNEF diagnostics in a multivariate logistic regression analysis. Conclusion Plasma levels of big endothelin, PIIINP, and MMP-2 were found to be associated with the presence of early diagnosed HFNEF. However, none of these biomarkers contributed independently to current noninvasive HFNEF diagnostics recommended by the European Society of Cardiology guidelines.
ER -
MELUZÍN, Jaroslav, Josef TOMANDL, Helena PODROUŽKOVÁ, Zdeňka GREGOROVÁ, Vladimír SOŠKA, Petr DOBŠÁK, Ladislav PECEN a Radka STEPANOVA. Can markers of collagen turnover or other biomarkers contribute to the diagnostics of heart failure with normal left ventricular ejection fraction? \textit{Biomedical Papers of the Faculty of Medicine and Dentistry of Palacký University, Olomouc, Czech Republic}. Olomouc: Palacký University, 2013, roč.~157, č.~4, s.~331-339. ISSN~1213-8118. Dostupné z: https://dx.doi.org/10.5507/bp.2012.110.
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