Haloperidol Cytotoxicity and Its Relation to Oxidative Stress

J 2013

Haloperidol Cytotoxicity and Its Relation to Oxidative Stress

RAUDENSKÁ, Martina, Jaromír GUMULEC, Petr BABULA, Tibor STRAČINA, Markéta SZTALMACHOVÁ et. al.

Basic information

Original name

Haloperidol Cytotoxicity and Its Relation to Oxidative Stress

Authors

RAUDENSKÁ, Martina (203 Czech Republic, belonging to the institution), Jaromír GUMULEC (203 Czech Republic, belonging to the institution), Petr BABULA (203 Czech Republic), Tibor STRAČINA (703 Slovakia, belonging to the institution), Markéta SZTALMACHOVÁ (203 Czech Republic, belonging to the institution), Hana POLANSKÁ (203 Czech Republic, belonging to the institution), Vojtech ADAM (203 Czech Republic), Rene KIZEK (203 Czech Republic), Marie NOVÁKOVÁ (203 Czech Republic, belonging to the institution) and Michal MASAŘÍK (203 Czech Republic, guarantor, belonging to the institution)

Edition

MINI-REVIEWS IN MEDICINAL CHEMISTRY, SHARJAH, BENTHAM SCIENCE PUBL LTD, 2013, 1389-5575

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30105 Physiology

Country of publisher

United Arab Emirates

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.186

RIV identification code

RIV/00216224:14110/13:00066629

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.2174/13895575113136660100

UT WoS

000328088300001

Keywords in English

Arrhytmia; cardiotoxicity; dopamine; haloperidol; oxidative stress; Torsade de Pointes

Abstract

V originále

Haloperidol (HP) is used for the symptomatic treatment of psychosis, manic phases, hyperactivity, aggressiveness, and acute delirium. Long-term use leads to various adverse side effects, especially to severe impairment of extrapyramidal nerve tracts and in particular, altered QT interval and increased incidence of arrhytmias. It is believed that cytotoxicity of HP and its metabolites is responsible for both neurotoxicity and cardiotoxicity. Extrapyramidal and cardiac adverse side effects may be explained by the HP-induced oxidative stress, as implicated by many studies. HP was reported to induce lipid peroxidation with subsequent membrane changes, responsible for cell death. Vice versa, cells resistant to oxidative stress are also resistant to the toxic effects of HP. Similarly, high percentage of patients suffering from extrapyramidal symptoms treated by vitamin E and other lipid-soluble antioxidants demonstrates diminishing of these adverse side effects. HP’s ability to induce oxidative stress by multi-modal action (increased metabolism of dopamine, decrease of glutathione content, induction of NF-B transcription factor, and inhibition of complex I of respiratory chain) has been established just recently. This review brings summarizing view on the cytotoxicity of haloperidol and involvement of reactive oxygen species and oxidative stress HP-induced cytotoxicity.

Links

GAP102/12/2034, research and development project

Name: Analýza vztahu mezi elektrickými ději a průtokem krve u srdečních komor

Investor: Czech Science Foundation

MUNI/A/0951/2012, interní kód MU

Name: Studium mechanismů vzniku vybraných kardiovaskulárních nemocí a poúrazových stavů (Acronym: SMEKAONUR)

Investor: Masaryk University, Category A

Citovat

RAUDENSKÁ, Martina, Jaromír GUMULEC, Petr BABULA, Tibor STRAČINA, Markéta SZTALMACHOVÁ, Hana POLANSKÁ, Vojtech ADAM, Rene KIZEK, Marie NOVÁKOVÁ and Michal MASAŘÍK. Haloperidol Cytotoxicity and Its Relation to Oxidative Stress. MINI-REVIEWS IN MEDICINAL CHEMISTRY. SHARJAH: BENTHAM SCIENCE PUBL LTD, 2013, vol. 13, No 14, p. 1993-1998. ISSN 1389-5575. Available from: https://dx.doi.org/10.2174/13895575113136660100.

@article{1137573,
   author = {Raudenská, Martina and Gumulec, Jaromír and Babula, Petr and Stračina, Tibor and Sztalmachová, Markéta and Polanská, Hana and Adam, Vojtech and Kizek, Rene and Nováková, Marie and Masařík, Michal},
   article_location = {SHARJAH},
   article_number = {14},
   doi = {http://dx.doi.org/10.2174/13895575113136660100},
   keywords = {Arrhytmia; cardiotoxicity; dopamine; haloperidol; oxidative stress; Torsade de Pointes},
   language = {eng},
   issn = {1389-5575},
   journal = {MINI-REVIEWS IN MEDICINAL CHEMISTRY},
   title = {Haloperidol Cytotoxicity and Its Relation to Oxidative Stress},
   volume = {13},
   year = {2013}
}

TY  - JOUR
ID  - 1137573
AU  - Raudenská, Martina - Gumulec, Jaromír - Babula, Petr - Stračina, Tibor - Sztalmachová, Markéta - Polanská, Hana - Adam, Vojtech - Kizek, Rene - Nováková, Marie - Masařík, Michal
PY  - 2013
TI  - Haloperidol Cytotoxicity and Its Relation to Oxidative Stress
JF  - MINI-REVIEWS IN MEDICINAL CHEMISTRY
VL  - 13
IS  - 14
SP  - 1993-1998
EP  - 1993-1998
PB  - BENTHAM SCIENCE PUBL LTD
SN  - 13895575
KW  - Arrhytmia
KW  - cardiotoxicity
KW  - dopamine
KW  - haloperidol
KW  - oxidative stress
KW  - Torsade de Pointes
N2  - Haloperidol (HP) is used for the symptomatic treatment of psychosis, manic phases, hyperactivity, aggressiveness, and acute delirium. Long-term use leads to various adverse side effects, especially to severe impairment of extrapyramidal nerve tracts and in particular, altered QT interval and increased incidence of arrhytmias. It is believed that cytotoxicity of HP and its metabolites is responsible for both neurotoxicity and cardiotoxicity. Extrapyramidal and cardiac adverse side effects may be explained by the HP-induced oxidative stress, as implicated by many studies. HP was reported to induce lipid peroxidation with subsequent membrane changes, responsible for cell death. Vice versa, cells resistant to oxidative stress are also resistant to the toxic effects of HP. Similarly, high percentage of patients suffering from extrapyramidal symptoms treated by vitamin E and other lipid-soluble antioxidants demonstrates diminishing of these adverse side effects. HP’s ability to induce oxidative stress by multi-modal action (increased metabolism of dopamine, decrease of glutathione content, induction of NF-B transcription factor, and inhibition of complex I of respiratory chain) has been established just recently. This review brings summarizing view on the cytotoxicity of haloperidol and involvement of reactive oxygen species and oxidative stress HP-induced cytotoxicity.
ER  -

RAUDENSKÁ, Martina, Jaromír GUMULEC, Petr BABULA, Tibor STRAČINA, Markéta SZTALMACHOVÁ, Hana POLANSKÁ, Vojtech ADAM, Rene KIZEK, Marie NOVÁKOVÁ and Michal MASAŘÍK. Haloperidol Cytotoxicity and Its Relation to Oxidative Stress. \textit{MINI-REVIEWS IN MEDICINAL CHEMISTRY}. SHARJAH: BENTHAM SCIENCE PUBL LTD, 2013, vol.~13, No~14, p.~1993-1998. ISSN~1389-5575. Available from: https://dx.doi.org/10.2174/13895575113136660100.

Detailed Information on Publication Record