| ČINČÁROVÁ, Lenka, Zbyněk ZDRÁHAL a Jiří FAJKUS. New perspectives of valproic acid in clinical practice. Expert Opinion on Investigational Drugs. Abingdon-on-Thames: TAYLOR & FRANCIS LTD, 2013, roč. 22, č. 12, s. 1535-1547. ISSN 1354-3784. Dostupné z: https://dx.doi.org/10.1517/13543784.2013.853037. |
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@article{1138417,
author = {Činčárová, Lenka and Zdráhal, Zbyněk and Fajkus, Jiří},
article_location = {Abingdon-on-Thames},
article_number = {12},
doi = {http://dx.doi.org/10.1517/13543784.2013.853037},
keywords = {CAR; combination therapy; HDAC inhibition; radiosensitization; TRAIL/Apo2L; valproic acid},
language = {eng},
issn = {1354-3784},
journal = {Expert Opinion on Investigational Drugs},
title = {New perspectives of valproic acid in clinical practice},
url = {http://informahealthcare.com/doi/abs/10.1517/13543784.2013.853037},
volume = {22},
year = {2013}
}
TY - JOUR
ID - 1138417
AU - Činčárová, Lenka - Zdráhal, Zbyněk - Fajkus, Jiří
PY - 2013
TI - New perspectives of valproic acid in clinical practice
JF - Expert Opinion on Investigational Drugs
VL - 22
IS - 12
SP - 1535-1547
EP - 1535-1547
PB - TAYLOR & FRANCIS LTD
SN - 13543784
KW - CAR
KW - combination therapy
KW - HDAC inhibition
KW - radiosensitization
KW - TRAIL/Apo2L
KW - valproic acid
UR - http://informahealthcare.com/doi/abs/10.1517/13543784.2013.853037
L2 - http://informahealthcare.com/doi/abs/10.1517/13543784.2013.853037
N2 - Introduction: Valproic acid (VPA) has been used in clinical practice as an anticonvulsant for more than four decades. Its pharmacokinetics and toxicity are thus well documented. VPA is also a potent class-selective histone deacetylase (HDAC) inhibitor at nontoxic therapeutic concentrations. New areas of application for VPA are currently opening up in clinical practice. Areas covered: The authors discuss VPA and how it may serve as an effective drug for cancer therapy. This is due to its ability to induce differentiation of a number of cancer cells in vitro and also to decrease tumor growth and metastases in animal models. The authors highlight how the utilization of VPA as an HDAC inhibitor is not limited to a single-agent therapy. Early clinical studies have also revealed promising potency of VPA in combination treatment with classic anticancer drugs. The authors do this by summarizing the published results and providing insight into the potential future developments for this field. Expert opinion: VPA was shown to restore or improve responsiveness of tumors to conventional therapeutic agents, to enhance the efficacy of adenoviral gene therapy, to sensitize TRAIL-resistant tumor cells to apoptosis, and to enhance radiosensitivity of tumor cells. Drawbacks in VPA medical applications include its teratogenicity and complexity of its effects.
ER -
ČINČÁROVÁ, Lenka, Zbyněk ZDRÁHAL a Jiří FAJKUS. New perspectives of valproic acid in clinical practice. \textit{Expert Opinion on Investigational Drugs}. Abingdon-on-Thames: TAYLOR \&{} FRANCIS LTD, 2013, roč.~22, č.~12, s.~1535-1547. ISSN~1354-3784. Dostupné z: https://dx.doi.org/10.1517/13543784.2013.853037.
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