Detailed Information on Publication Record
2013
Molecular mechanisms of neuropathological changes in Alzheimer`s disease: a review
ŠERÝ, Omar, Jana POVOVÁ, Ivan MÍŠEK, Lukáš PEŠÁK, Vladimír JANOUT et. al.Basic information
Original name
Molecular mechanisms of neuropathological changes in Alzheimer`s disease: a review
Authors
ŠERÝ, Omar (203 Czech Republic, guarantor, belonging to the institution), Jana POVOVÁ (203 Czech Republic), Ivan MÍŠEK (203 Czech Republic), Lukáš PEŠÁK (203 Czech Republic) and Vladimír JANOUT (203 Czech Republic)
Edition
Folia Neuropathologica, 2013, 1641-4640
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30105 Physiology
Country of publisher
Poland
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 1.667
RIV identification code
RIV/00216224:14310/13:00065652
Organization unit
Faculty of Science
UT WoS
000317316400001
Keywords in English
Alzheimer`s disease; amyloid precursor protein; tau protein; apolipoprotein E
Změněno: 7/4/2014 22:22, Ing. Andrea Mikešková
Abstract
V originále
More than 100 years after description of Alzheimer's disease (AD), two major pathological processes observed already by Alois Alzheimer, remain as the main explanation of the pathogenesis of Alzheimer's disease. Important molecular interactions leading to AD neuropathology were described in amyloid cascade and in tau protein function. No clinical trials with novel therapies based on amyloid cascade and tau protein hypotheses have been successful. The main aim of recent research is focused on the question what is primary mechanism leading to the molecular development of AD pathology. Promising explanation of triggering mechanism can be seen in vascular pathology that have direct influence on the development of pathological processes typical for Alzheimer disease. Novel insight into a number of cellular signaling mechanisms, as well as mitochondrial function in Alzheimer disease could also bring explanations of initial processes leading to the development of this pathology.
Links
| NT11152, research and development project |
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