Detailed Information on Publication Record
2012
Detection of cancer stem cell markers in sarcomas
VESELSKÁ, Renata, Jakub NERADIL and Jan ŠKODABasic information
Original name
Detection of cancer stem cell markers in sarcomas
Authors
VESELSKÁ, Renata (203 Czech Republic, guarantor, belonging to the institution), Jakub NERADIL (203 Czech Republic, belonging to the institution) and Jan ŠKODA (203 Czech Republic, belonging to the institution)
Edition
Klinická onkologie, Brno, C̆eská onkologická spolec̆nost, 2012, 0862-495X
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30200 3.2 Clinical medicine
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
RIV identification code
RIV/00216224:14310/12:00065657
Organization unit
Faculty of Science
Keywords in English
cancer stem cells; osteosarcoma; rhabdomyosarcoma; CD133; ABC transporters; nestin; aldehyde dehydrogenase; tumorigenicity
Tags
International impact, Reviewed
Změněno: 25/11/2015 22:23, prof. RNDr. Renata Veselská, Ph.D., M.Sc.
Abstract
V originále
The identification of cancer stem cell markers represents one of the very relevant research topics because cancer stem cells play important roles in tumour initiation and progression, as well as during metastasis formation and in relapse of the disease. This article summarises recent knowledge on well-known and putative cancer stem cell markers in various types of bone and soft-tissue sarcomas. Special attention is paid to the detection of CD133, ABC transporters, nestin and aldehyde dehydrogenase that have been intensively studied both in tumour tissues and in sarcoma cell lines during the past few years. Finally, an overview is given of the possible CSC phenotypes provided by functional assays of tumourigenicity.
Links
| NT13443, research and development project |
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