Practical issues in the treatment of schizophrenia

J 2013

Practical issues in the treatment of schizophrenia

ČEŠKOVÁ, Eva

Základní údaje

Originální název

Practical issues in the treatment of schizophrenia

Autoři

ČEŠKOVÁ, Eva (203 Česká republika, garant, domácí)

Vydání

Minerva Psichiatrica, Edizioni Minerva Medica S.p.A. 2013, 0391-1772

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Itálie

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Kód RIV

RIV/00216224:14740/13:00071043

Organizační jednotka

Středoevropský technologický institut

Klíčová slova anglicky

Evidence-based medicine; Individualized medicine; Schizophrenia

Štítky

ok, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 16. 1. 2014 08:50, Olga Křížová

Anotace

V originále

Treatment should be evidence-based, measurement-based, complex (including pharmacotherapy, psychosocial intervention, and physical health care) and individualized (tailored to the patient). The basis of schizophrenia treatment is still pharmacotherapy. The first generation of antipsychotics (FGAs), known as typical APs, was discovered in the 1950s. Most second generation antipsychotics (SGAs), known as atypical APs, have been developed more recently. SGAs present some advantages in the treatment of certain treatment domains. The binding affinity of APs for specific neuroreceptors is associated with the therapeutic effect, but also with adverse events. The choice of AP for the individual patient should be guided by the side effect profile of the drug, patient experience with certain side effects, previous patient response to certain APs (e.g., individualized treatment), and potential interactions with other prescribed medication. There are some special clinical features influencing the choice of AP treatment (negative, cognitive, depressive and catatonic symptoms, agitation, non-adherence, pharmacoresistance). These features are discussed in more details. In the future more targeted therapies will be available, offering and enhance efficacy and hopefully also safety.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

Citovat

ČEŠKOVÁ, Eva. Practical issues in the treatment of schizophrenia. Minerva Psichiatrica. Edizioni Minerva Medica S.p.A., 2013, roč. 54, č. 2, s. 101-113. ISSN 0391-1772.

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   article_number = {2},
   keywords = {Evidence-based medicine; Individualized medicine; Schizophrenia},
   language = {eng},
   issn = {0391-1772},
   journal = {Minerva Psichiatrica},
   title = {Practical issues in the treatment of schizophrenia},
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   volume = {54},
   year = {2013}
}

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N2  - Treatment should be evidence-based, measurement-based, complex (including pharmacotherapy, psychosocial intervention, and physical health care) and individualized (tailored to the patient). The basis of schizophrenia treatment is still pharmacotherapy. The first generation of antipsychotics (FGAs), known as typical APs, was discovered in the 1950s. Most second generation antipsychotics (SGAs), known as atypical APs, have been developed more recently. SGAs present some advantages in the treatment of certain treatment domains. The binding affinity of APs for specific neuroreceptors is associated with the therapeutic effect, but also with adverse events. The choice of AP for the individual patient should be guided by the side effect profile of the drug, patient experience with certain side effects, previous patient response to certain APs (e.g., individualized treatment), and potential interactions with other prescribed medication. There are some special clinical features influencing the choice of AP treatment (negative, cognitive, depressive and catatonic symptoms, agitation, non-adherence, pharmacoresistance). These features are discussed in more details. In the future more targeted therapies will be available, offering and enhance efficacy and hopefully also safety.
ER  -

ČEŠKOVÁ, Eva. Practical issues in the treatment of schizophrenia. \textit{Minerva Psichiatrica}. Edizioni Minerva Medica S.p.A., 2013, roč.~54, č.~2, s.~101-113. ISSN~0391-1772.

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