Association of Surface Contamination by Antineoplastic Drugs
With Different Working Conditions in Hospital Pharmacies

J 2014

Association of Surface Contamination by Antineoplastic Drugs With Different Working Conditions in Hospital Pharmacies

ODRÁŠKA, Pavel, Lenka DOLEZALOVA, Jan KUTA, Michal ORAVEC, Pavel PILER et. al.

Základní údaje

Originální název

Association of Surface Contamination by Antineoplastic Drugs With Different Working Conditions in Hospital Pharmacies

Autoři

ODRÁŠKA, Pavel (203 Česká republika, garant, domácí), Lenka DOLEZALOVA (203 Česká republika), Jan KUTA (203 Česká republika, domácí), Michal ORAVEC (203 Česká republika, domácí), Pavel PILER (203 Česká republika, domácí), Stanislav SYNEK (203 Česká republika) a Luděk BLÁHA (203 Česká republika, domácí)

Vydání

ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH, ABINGDON, ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, 2014, 1933-8244

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30304 Public and environmental health

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 0.932

Kód RIV

RIV/00216224:14310/14:00074907

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1080/19338244.2013.763757

UT WoS

000328103500005

Klíčová slova anglicky

antineoplastic agents; carcinogens; chemical exposure; cytotoxic drugs; exposure assessment; surface contamination

Štítky

AKR, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 21. 1. 2015 16:09, Ing. Andrea Mikešková

Anotace

V originále

This study investigates the surface contamination levels of cyclophosphamide and platinum (a marker of platinum-containing drugs) in storage and preparation areas of hospital pharmacies and their relationship to working conditions surveyed by questionnaire. In total, 259 wipe samples were collected in 13 hospital pharmacies over 4 sampling campaigns. After sample extraction with acetate buffer, cyclophosphamide and platinum were determined using high-performance liquid chromatography-tandem mass spectroscopy (HPLC-MS/MS) and inductively coupled plasma mass spectrometry (ICP-MS). Depending on the sampling spot and campaign, median concentrations ranged from <2 to 61 pg/cm(2) and from <0.2 to 6.9 pg/cm(2) for cyclophosphamide and platinum, respectively. Statistical evaluation of monitoring data revealed that the contamination level was significantly influenced by laboratory throughput (expressed as number of chemotherapies prepared per week), personnel expertise (ie, participation of pharmacists with academic education in drug admixture activities), and surface material.

Návaznosti

ED0001/01/01, projekt VaV

Název: CETOCOEN

Citovat

ODRÁŠKA, Pavel, Lenka DOLEZALOVA, Jan KUTA, Michal ORAVEC, Pavel PILER, Stanislav SYNEK a Luděk BLÁHA. Association of Surface Contamination by Antineoplastic Drugs With Different Working Conditions in Hospital Pharmacies. ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH. ABINGDON: ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, 2014, roč. 69, č. 3, s. 148-158. ISSN 1933-8244. Dostupné z: https://dx.doi.org/10.1080/19338244.2013.763757.

@article{1159640,
   author = {Odráška, Pavel and Dolezalova, Lenka and Kuta, Jan and Oravec, Michal and Piler, Pavel and Synek, Stanislav and Bláha, Luděk},
   article_location = {ABINGDON},
   article_number = {3},
   doi = {http://dx.doi.org/10.1080/19338244.2013.763757},
   keywords = {antineoplastic agents; carcinogens; chemical exposure; cytotoxic drugs; exposure assessment; surface contamination},
   language = {eng},
   issn = {1933-8244},
   journal = {ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH},
   title = {Association of Surface Contamination by Antineoplastic Drugs With Different Working Conditions in Hospital Pharmacies},
   volume = {69},
   year = {2014}
}

TY  - JOUR
ID  - 1159640
AU  - Odráška, Pavel - Dolezalova, Lenka - Kuta, Jan - Oravec, Michal - Piler, Pavel - Synek, Stanislav - Bláha, Luděk
PY  - 2014
TI  - Association of Surface Contamination by Antineoplastic Drugs With Different Working Conditions in Hospital Pharmacies
JF  - ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH
VL  - 69
IS  - 3
SP  - 148-158
EP  - 148-158
PB  - ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
SN  - 19338244
KW  - antineoplastic agents
KW  - carcinogens
KW  - chemical exposure
KW  - cytotoxic drugs
KW  - exposure assessment
KW  - surface contamination
N2  - This study investigates the surface contamination levels of cyclophosphamide and platinum (a marker of platinum-containing drugs) in storage and preparation areas of hospital pharmacies and their relationship to working conditions surveyed by questionnaire. In total, 259 wipe samples were collected in 13 hospital pharmacies over 4 sampling campaigns. After sample extraction with acetate buffer, cyclophosphamide and platinum were determined using high-performance liquid chromatography-tandem mass spectroscopy (HPLC-MS/MS) and inductively coupled plasma mass spectrometry (ICP-MS). Depending on the sampling spot and campaign, median concentrations ranged from <2 to 61 pg/cm(2) and from <0.2 to 6.9 pg/cm(2) for cyclophosphamide and platinum, respectively. Statistical evaluation of monitoring data revealed that the contamination level was significantly influenced by laboratory throughput (expressed as number of chemotherapies prepared per week), personnel expertise (ie, participation of pharmacists with academic education in drug admixture activities), and surface material.
ER  -

ODRÁŠKA, Pavel, Lenka DOLEZALOVA, Jan KUTA, Michal ORAVEC, Pavel PILER, Stanislav SYNEK a Luděk BLÁHA. Association of Surface Contamination by Antineoplastic Drugs With Different Working Conditions in Hospital Pharmacies. \textit{ARCHIVES OF ENVIRONMENTAL \&{}amp; OCCUPATIONAL HEALTH}. ABINGDON: ROUTLEDGE JOURNALS, TAYLOR \&{}amp; FRANCIS LTD, 2014, roč.~69, č.~3, s.~148-158. ISSN~1933-8244. Dostupné z: https://dx.doi.org/10.1080/19338244.2013.763757.

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