microRNAs in nociceptive circuits as predictors of future clinical applications

@article{1161992,
   author = {Kress, Michaela and Hüttenhofer, Alexander and Landry, Marc and Kuner, Rohini and Favereaux, Alexandre and Greenberg, David and Bednařík, Josef and Heppenstall, Paul and Kronenberg, Florian and Malcangio, Marzia and Rittner, Heike and Üçeyler, Nurcan and Trajanoski, Zlatko and Mouritzen, Peter and Birklein, Frank and Sommer, Claudia and Soreq, Hermona},
   article_location = {Lausanne},
   article_number = {art. 33},
   doi = {http://dx.doi.org/10.3389/fnmol.2013.00033},
   keywords = {Antagomir; Biomarker; Chronic pain; miRNA expression patterns; miRNA polymorphisms; miRNA-based analgesic; miRNA-based diagnostics; Polymorphism},
   language = {eng},
   issn = {1662-5099},
   journal = {Frontiers in Molecular Neuroscience},
   title = {microRNAs in nociceptive circuits as predictors of future clinical applications},
   volume = {6},
   year = {2013}
}

TY  - JOUR
ID  - 1161992
AU  - Kress, Michaela - Hüttenhofer, Alexander - Landry, Marc - Kuner, Rohini - Favereaux, Alexandre - Greenberg, David - Bednařík, Josef - Heppenstall, Paul - Kronenberg, Florian - Malcangio, Marzia - Rittner, Heike - Üçeyler, Nurcan - Trajanoski, Zlatko - Mouritzen, Peter - Birklein, Frank - Sommer, Claudia - Soreq, Hermona
PY  - 2013
TI  - microRNAs in nociceptive circuits as predictors of future clinical applications
JF  - Frontiers in Molecular Neuroscience
VL  - 6
IS  - art. 33
SP  - 1-11
EP  - 1-11
PB  - Frontiers Research Foundation
SN  - 16625099
KW  - Antagomir
KW  - Biomarker
KW  - Chronic pain
KW  - miRNA expression patterns
KW  - miRNA polymorphisms
KW  - miRNA-based analgesic
KW  - miRNA-based diagnostics
KW  - Polymorphism
N2  - Neuro-immune alterations in the peripheral and central nervous system play a role in the pathophysiology of chronic pain, and non-coding RNAs - and microRNAs (miRNAs) in particular - regulate both immune and neuronal processes. Specifically, miRNAs control macromolecular complexes in neurons, glia and immune cells and regulate signals used for neuro-immune communication in the pain pathway. Therefore, miRNAs may be hypothesized as critically important master switches modulating chronic pain. In particular, understanding the concerted function of miRNA in the regulation of nociception and endogenous analgesia and defining the importance of miRNAs in the circuitries and cognitive, emotional and behavioral components involved in pain is expected to shed new light on the enigmatic pathophysiology of neuropathic pain, migraine and complex regional pain syndrome. Specific miRNAs may evolve as new druggable molecular targets for pain prevention and relief. Furthermore, predisposing miRNA expression patterns and inter-individual variations and polymorphisms in miRNAs and/or their binding sites may serve as biomarkers for pain and help to predict individual risks for certain types of pain and responsiveness to analgesic drugs. miRNA-based diagnostics are expected to develop into hands-on tools that allow better patient stratification, improved mechanism-based treatment, and targeted prevention strategies for high risk individuals.
ER  - 

KRESS, Michaela, Alexander HÜTTENHOFER, Marc LANDRY, Rohini KUNER, Alexandre FAVEREAUX, David GREENBERG, Josef BEDNAŘÍK, Paul HEPPENSTALL, Florian KRONENBERG, Marzia MALCANGIO, Heike RITTNER, Nurcan Ü$\backslash$C CEYLER, Zlatko TRAJANOSKI, Peter MOURITZEN, Frank BIRKLEIN, Claudia SOMMER a Hermona SOREQ. microRNAs in nociceptive circuits as predictors of future clinical applications. \textit{Frontiers in Molecular Neuroscience}. Lausanne: Frontiers Research Foundation, 2013, roč.~6, art. 33, s.~1-11. ISSN~1662-5099. Dostupné z: https://dx.doi.org/10.3389/fnmol.2013.00033.