KEJNOVSKÝ, Eduard and Matej LEXA. Quadruplex-forming DNA sequences spread by retrotransposons may serve as genome regulators. Mobile Genetic Elements, Landes Bioscience, 2014, vol. 4, No 1, p. "e28084". ISSN 2159-256X. doi:10.4161/mge.28084.
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Basic information
Original name Quadruplex-forming DNA sequences spread by retrotransposons may serve as genome regulators
Authors KEJNOVSKÝ, Eduard (203 Czechia, guarantor) and Matej LEXA (703 Slovakia, belonging to the institution).
Edition Mobile Genetic Elements, Landes Bioscience, 2014, 2159-256X.
Other information
Original language English
Type of outcome article in a journal
Field of Study 10608 Biochemistry and molecular biology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14740/14:00075019
Organization unit Central European Institute of Technology
Keywords in English LTR retrotransposons; DNA quadruplexes; TE transcription
Tags podil, WOS
Tags International impact, Reviewed
Changed by Changed by: Ing. Matej Lexa, Ph.D., učo 31298. Changed: 13/3/2018 14:13.
Transposable elements (TEs) are ubiquitous genome inhabitants in eukaryotes. Increasing evidence shows that TEs are involved in regulatory networks of eukaryotic cells and contribute to genome evolution. Recently, we reported that many plant long-terminal repeat (LTR) retrotransposons contain DNA quadruplex-forming sequences at precise positions inside their LTRs and that quadruplexes are better preserved in evolutionary younger elements. As quadruplexes can modulate molecular processes, quadruplexes found at specific distances upstream and downstream from the endogenous TE promoter can affect transcription of the element. Moreover, quadruplexes found in solo LTRs, as well as in 3 ends of 5-truncated copies of LINE-1 elements, can affect expression of neighboring genes. Here, we propose that this way retrotransposons can serve as vehicles for spread of DNA quadruplexes. Quadruplexes can thus fulfill a dual regulatory role to influence both the retrotransposons carrying them and the neighboring host genes, e.g., by direct effect on transcription or by modifying the local chromatin state. Additionally, four-stranded DNA structures may serve as hotspots for recombination-based genome rearrangements.
ED1.1.00/02.0068, research and development projectName: CEITEC - central european institute of technology
EE2.3.20.0045, research and development projectName: Podpora profesního růstu a mezinárodní integrace výzkumných týmů v oblasti molekulární medicíny
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