Quadruplex-forming DNA sequences spread by retrotransposons may
serve as genome regulators

J 2014

Quadruplex-forming DNA sequences spread by retrotransposons may serve as genome regulators

KEJNOVSKÝ, Eduard a Matej LEXA

Základní údaje

Originální název

Quadruplex-forming DNA sequences spread by retrotransposons may serve as genome regulators

Autoři

KEJNOVSKÝ, Eduard (203 Česká republika, garant) a Matej LEXA (703 Slovensko, domácí)

Vydání

Mobile Genetic Elements, Landes Bioscience, 2014, 2159-256X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Kód RIV

RIV/00216224:14740/14:00075019

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.4161/mge.28084

Klíčová slova anglicky

LTR retrotransposons; DNA quadruplexes; TE transcription

Štítky

podil, WOS

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 13. 3. 2018 14:13, doc. Ing. Matej Lexa, Ph.D.

Anotace

V originále

Transposable elements (TEs) are ubiquitous genome inhabitants in eukaryotes. Increasing evidence shows that TEs are involved in regulatory networks of eukaryotic cells and contribute to genome evolution. Recently, we reported that many plant long-terminal repeat (LTR) retrotransposons contain DNA quadruplex-forming sequences at precise positions inside their LTRs and that quadruplexes are better preserved in evolutionary younger elements. As quadruplexes can modulate molecular processes, quadruplexes found at specific distances upstream and downstream from the endogenous TE promoter can affect transcription of the element. Moreover, quadruplexes found in solo LTRs, as well as in 3 ends of 5-truncated copies of LINE-1 elements, can affect expression of neighboring genes. Here, we propose that this way retrotransposons can serve as vehicles for spread of DNA quadruplexes. Quadruplexes can thus fulfill a dual regulatory role to influence both the retrotransposons carrying them and the neighboring host genes, e.g., by direct effect on transcription or by modifying the local chromatin state. Additionally, four-stranded DNA structures may serve as hotspots for recombination-based genome rearrangements.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

EE2.3.20.0045, projekt VaV

Název: Podpora profesního růstu a mezinárodní integrace výzkumných týmů v oblasti molekulární medicíny

Citovat

KEJNOVSKÝ, Eduard a Matej LEXA. Quadruplex-forming DNA sequences spread by retrotransposons may serve as genome regulators. Mobile Genetic Elements. Landes Bioscience, 2014, roč. 4, č. 1, s. "e28084", 4 s. ISSN 2159-256X. Dostupné z: https://dx.doi.org/10.4161/mge.28084.

@article{1163907,
   author = {Kejnovský, Eduard and Lexa, Matej},
   article_number = {1},
   doi = {http://dx.doi.org/10.4161/mge.28084},
   keywords = {LTR retrotransposons; DNA quadruplexes; TE transcription},
   language = {eng},
   issn = {2159-256X},
   journal = {Mobile Genetic Elements},
   title = {Quadruplex-forming DNA sequences spread by retrotransposons may serve as genome regulators},
   url = {https://www.landesbioscience.com/journals/mge/article/28084/},
   volume = {4},
   year = {2014}
}

TY  - JOUR
ID  - 1163907
AU  - Kejnovský, Eduard - Lexa, Matej
PY  - 2014
TI  - Quadruplex-forming DNA sequences spread by retrotransposons may serve as genome regulators
JF  - Mobile Genetic Elements
VL  - 4
IS  - 1
SP  - "e28084"
EP  - "e28084"
PB  - Landes Bioscience
SN  - 2159256X
KW  - LTR retrotransposons
KW  - DNA quadruplexes
KW  - TE transcription
UR  - https://www.landesbioscience.com/journals/mge/article/28084/
L2  - https://www.landesbioscience.com/journals/mge/article/28084/
N2  - Transposable elements (TEs) are ubiquitous genome inhabitants in eukaryotes. Increasing evidence shows that TEs are involved in regulatory networks of eukaryotic cells and contribute to genome evolution. Recently, we reported that many plant long-terminal repeat (LTR) retrotransposons contain DNA quadruplex-forming sequences at precise positions inside their LTRs and that quadruplexes are better preserved in evolutionary younger elements. As quadruplexes can modulate molecular processes, quadruplexes found at specific distances upstream and downstream from the endogenous TE promoter can affect transcription of the element. Moreover, quadruplexes found in solo LTRs, as well as in 3 ends of 5-truncated copies of LINE-1 elements, can affect expression of neighboring genes. Here, we propose that this way retrotransposons can serve as vehicles for spread of DNA quadruplexes. Quadruplexes can thus fulfill a dual regulatory role to influence both the retrotransposons carrying them and the neighboring host genes, e.g., by direct effect on transcription or by modifying the local chromatin state. Additionally, four-stranded DNA structures may serve as hotspots for recombination-based genome rearrangements.
ER  -

KEJNOVSKÝ, Eduard a Matej LEXA. Quadruplex-forming DNA sequences spread by retrotransposons may serve as genome regulators. \textit{Mobile Genetic Elements}. Landes Bioscience, 2014, roč.~4, č.~1, s.~''e28084'', 4 s. ISSN~2159-256X. Dostupné z: https://dx.doi.org/10.4161/mge.28084.

Podrobný výpis o publikaci