| VLACHOVSKÝ, Robert, Robert STAFFA, Martin DVORAK, Michal VLASIN, Markéta HERMANOVÁ, Thomas O’BRIEN and Timothy MCGLOUGHLIN. Evaluation of a novel vascular graft with a distal bifurcation designed to reduce the development of intimal hyperplasia. Experimental study in a porcine aorta model. Biomedical Papers. Olomouc: Palacky University, 2014, vol. 158, No 4, p. 562-568. ISSN 1213-8118. Available from: https://dx.doi.org/10.5507/bp.2013.021. |
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@article{1168390,
author = {Vlachovský, Robert and Staffa, Robert and Dvorak, Martin and Vlasin, Michal and Hermanová, Markéta and O’Brien, Thomas and McGloughlin, Timothy},
article_location = {Olomouc},
article_number = {4},
doi = {http://dx.doi.org/10.5507/bp.2013.021},
keywords = {animal model; anastomosis; graft design; distal bifurcation; intimal hyperplasia; experimental study; pig},
language = {eng},
issn = {1213-8118},
journal = {Biomedical Papers},
title = {Evaluation of a novel vascular graft with a distal bifurcation designed to reduce the development of intimal hyperplasia. Experimental study in a porcine aorta model},
volume = {158},
year = {2014}
}
TY - JOUR
ID - 1168390
AU - Vlachovský, Robert - Staffa, Robert - Dvorak, Martin - Vlasin, Michal - Hermanová, Markéta - O’Brien, Thomas - McGloughlin, Timothy
PY - 2014
TI - Evaluation of a novel vascular graft with a distal bifurcation designed to reduce the development of intimal hyperplasia. Experimental study in a porcine aorta model
JF - Biomedical Papers
VL - 158
IS - 4
SP - 562-568
EP - 562-568
PB - Palacky University
SN - 12138118
KW - animal model
KW - anastomosis
KW - graft design
KW - distal bifurcation
KW - intimal hyperplasia
KW - experimental study
KW - pig
N2 - Objective. Abnormal haemodynamics is commonly agreed to be a major contributor to the development of distal anastomotic intimal hyperplasia. A new vascular graft design proposed by computational studies was used to demonstrate its surgical feasibility and to compare it with the conventional graft in a porcine model. Method. The device was used in 12 eight-month-old pigs, six received the new graft and six had a conventional graft. The proximal graft end was implanted into the aorta, the distal graft end was implanted into the iliac artery. The host artery was ligated in order to simulate occlusion. At 20 weeks after surgery the pigs were killed and the device was excised for histological and morphometric analysis. Results. In five experimental grafts the reconstruction was occluded due to thrombosis; only one prosthesis was patent showing a minimum of neointimal hyperplasia. In the control group too only three of the six grafts were patent. A histological analysis revealed, as the cause of occlusion, fibrous tissue overgrowth corresponding in structure to neointimal hyperplasia. Differences in the number of obliterations and in occlusion rates between the profiles of the two groups were evaluated using the median test (P<0.05). The results were not statistically significant. Conclusion. Although mathematical modelling had shown significant haemodynamic benefits of a naturally bifurcated graft, our study did not confirm its superiority over conventionally used prostheses.
ER -
VLACHOVSKÝ, Robert, Robert STAFFA, Martin DVORAK, Michal VLASIN, Markéta HERMANOVÁ, Thomas O’BRIEN and Timothy MCGLOUGHLIN. Evaluation of a novel vascular graft with a distal bifurcation designed to reduce the development of intimal hyperplasia. Experimental study in a porcine aorta model. \textit{Biomedical Papers}. Olomouc: Palacky University, 2014, vol.~158, No~4, p.~562-568. ISSN~1213-8118. Available from: https://dx.doi.org/10.5507/bp.2013.021.
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