2014
Prevalence of Helicobacter pylori in adenotonsillar hypertrophy in children
KRAUS, Jaroslav, Eva NÁRTOVÁ, Emil PAVLÍK, Rami KATRA, Ivan ŠTERZL et. al.Základní údaje
Originální název
Prevalence of Helicobacter pylori in adenotonsillar hypertrophy in children
Autoři
KRAUS, Jaroslav, Eva NÁRTOVÁ, Emil PAVLÍK, Rami KATRA, Ivan ŠTERZL a Jaromír ASTL
Vydání
ACTA OTO-LARYNGOLOGICA, LONDON, INFORMA HEALTHCARE, 2014, 0001-6489
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Utajení
není předmětem státního či obchodního tajemství
Impakt faktor
Impact factor: 1.099
UT WoS
000329058700013
Klíčová slova anglicky
Adenoid; tonsils; PCR; pharynx
Změněno: 21. 3. 2014 13:55, MUDr. Jaroslav Kraus, Ph.D.
Anotace
V originále
Conclusion: Our results encourage the notion that the pharynx could be an extragastric reservoir of Helicobacter pylori (HP). The study confirmed the presence of HP in adenotonsillar tissue in children. It could have importance in the pathophysiology of upper respiratory diseases. However, its precise role in these processes remains unclear and requires further studies. Objective: A prospective study was carried out to evaluate the presence of HP in tonsillar and adenoid tissue in children. The study focused on real-time PCR analyzing CagA and VacA genotypes of HP strains. Methods: A total of 37 consecutive pediatric patients with adenotonsillar hypertrophy indicated for surgery were observed in a prospective study. Adenoidectomy and/or tonsillectomy was performed in each patient; 49 specimens were taken, 32 from adenoids and 17 from tonsils. The presence of HP and its genotype were tested in all samples by real-time PCR analysis. Results: Of 49 samples analyzed, 48 were positive for the presence of HP (98%), so only 1 sample was negative. While the genotype VacAs1bm2 was definitely dominant in adenoid tissue, wider distribution was observed in tonsillar tissue. Cag(+) strains represented one-fifth of all samples (21%).