Multiple gene-to-gene interactions in children with sepsis: a
combination of five gene variants predicts outcome of
life-threatening sepsis

J 2014

Multiple gene-to-gene interactions in children with sepsis: a combination of five gene variants predicts outcome of life-threatening sepsis

JABANDŽIEV, Petr, Michal SMEREK, Jaroslav Sr. MICHALEK, Michal FEDORA, Lucie KOŠINOVÁ et. al.

Základní údaje

Originální název

Multiple gene-to-gene interactions in children with sepsis: a combination of five gene variants predicts outcome of life-threatening sepsis

Autoři

JABANDŽIEV, Petr (203 Česká republika, garant, domácí), Michal SMEREK (203 Česká republika), Jaroslav Sr. MICHALEK (203 Česká republika), Michal FEDORA (203 Česká republika, domácí), Lucie KOŠINOVÁ (203 Česká republika), Jaroslav A. HUBACEK (203 Česká republika) a Jaroslav MICHÁLEK (203 Česká republika, domácí)

Vydání

Critical Care, LONDON, BioMed Central, 2014, 1466-609X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30209 Paediatrics

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.476

Kód RIV

RIV/00216224:14110/14:00080126

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1186/cc13174

UT WoS

000338991900038

Klíčová slova anglicky

sepsis; children; gene; single nucleotide polymorphism

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 17. 9. 2014 15:09, Soňa Böhmová

Anotace

V originále

Introduction: The aim of the study was to identify the dependency structure of genetic variants that can influence the outcome for paediatric patients with sepsis. Methods: We evaluated the role of single nucleotide polymorphisms for five genes: bactericidal permeability increasing protein (BPI; rs5743507), lipopolysaccharide-binding protein (LBP; rs2232618), toll-like receptor 4 (TLR4; rs4986790), heat shock protein 70 (HSP 70; rs2227956), and interleukin 6 (IL-6; rs1800795) in 598 children aged 0 to 19 years that were admitted to a paediatric intensive care unit with fever, systemic inflammatory response syndrome, sepsis, severe sepsis, septic shock, or multiple organ dysfunction syndrome. A control group of 529 healthy individuals was included. Multi-way contingency tables were constructed and statistically evaluated using log-linear models. Typical gene combinations were found for both study groups. Results: Detailed analyses of the five studied gene profiles revealed significant differences in sepsis survival. Stratification into high-risk, intermediate-risk, and low-risk groups of paediatric patients can predict the severity of sepsis. Conclusions: Analysis of single nucleotide polymorphisms for five genes can be used as a predictor of sepsis outcome in children.

Návaznosti

NS9894, projekt VaV

Název: Role SIRS, NO a oxidativního stresu v rozvoji šokového stavu a mitochondriální dysfunkce jako podklad multiorgánového selhání

Investor: Ministerstvo zdravotnictví ČR, Role SIRS, NO a oxidativního stresu v rozvoji šokového stavu a mitochondriální dysfunkce jako podklad multiorgánového selhání

Citovat

JABANDŽIEV, Petr, Michal SMEREK, Jaroslav Sr. MICHALEK, Michal FEDORA, Lucie KOŠINOVÁ, Jaroslav A. HUBACEK a Jaroslav MICHÁLEK. Multiple gene-to-gene interactions in children with sepsis: a combination of five gene variants predicts outcome of life-threatening sepsis. Critical Care. LONDON: BioMed Central, 2014, roč. 18, č. 1, s. 1-9. ISSN 1466-609X. Dostupné z: https://dx.doi.org/10.1186/cc13174.

@article{1173452,
   author = {Jabandžiev, Petr and Smerek, Michal and Michalek, Jaroslav Sr. and Fedora, Michal and Košinová, Lucie and Hubacek, Jaroslav A. and Michálek, Jaroslav},
   article_location = {LONDON},
   article_number = {1},
   doi = {http://dx.doi.org/10.1186/cc13174},
   keywords = {sepsis; children; gene; single nucleotide polymorphism},
   language = {eng},
   issn = {1466-609X},
   journal = {Critical Care},
   title = {Multiple gene-to-gene interactions in children with sepsis: a combination of five gene variants predicts outcome of life-threatening sepsis},
   url = {http://ccforum.com/content/pdf/cc13174.pdf},
   volume = {18},
   year = {2014}
}

TY  - JOUR
ID  - 1173452
AU  - Jabandžiev, Petr - Smerek, Michal - Michalek, Jaroslav Sr. - Fedora, Michal - Košinová, Lucie - Hubacek, Jaroslav A. - Michálek, Jaroslav
PY  - 2014
TI  - Multiple gene-to-gene interactions in children with sepsis: a combination of five gene variants predicts outcome of life-threatening sepsis
JF  - Critical Care
VL  - 18
IS  - 1
SP  - 1-9
EP  - 1-9
PB  - BioMed Central
SN  - 1466609X
KW  - sepsis
KW  - children
KW  - gene
KW  - single nucleotide polymorphism
UR  - http://ccforum.com/content/pdf/cc13174.pdf
N2  - Introduction: The aim of the study was to identify the dependency structure of genetic variants that can influence the outcome for paediatric patients with sepsis. Methods: We evaluated the role of single nucleotide polymorphisms for five genes: bactericidal permeability increasing protein (BPI; rs5743507), lipopolysaccharide-binding protein (LBP; rs2232618), toll-like receptor 4 (TLR4; rs4986790), heat shock protein 70 (HSP 70; rs2227956), and interleukin 6 (IL-6; rs1800795) in 598 children aged 0 to 19 years that were admitted to a paediatric intensive care unit with fever, systemic inflammatory response syndrome, sepsis, severe sepsis, septic shock, or multiple organ dysfunction syndrome. A control group of 529 healthy individuals was included. Multi-way contingency tables were constructed and statistically evaluated using log-linear models. Typical gene combinations were found for both study groups. Results: Detailed analyses of the five studied gene profiles revealed significant differences in sepsis survival. Stratification into high-risk, intermediate-risk, and low-risk groups of paediatric patients can predict the severity of sepsis. Conclusions: Analysis of single nucleotide polymorphisms for five genes can be used as a predictor of sepsis outcome in children.
ER  -

JABANDŽIEV, Petr, Michal SMEREK, Jaroslav Sr. MICHALEK, Michal FEDORA, Lucie KOŠINOVÁ, Jaroslav A. HUBACEK a Jaroslav MICHÁLEK. Multiple gene-to-gene interactions in children with sepsis: a combination of five gene variants predicts outcome of life-threatening sepsis. \textit{Critical Care}. LONDON: BioMed Central, 2014, roč.~18, č.~1, s.~1-9. ISSN~1466-609X. Dostupné z: https://dx.doi.org/10.1186/cc13174.

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