| SVOBODA, Miroslav, Jana SLYSKOVA, Michaela SCHNEIDEROVA, Peter MAKOVICKY, Ludovit BIELIK, Miroslav LEVY, Ludmila LIPSKA, Beáta HEMMELOVÁ, Zdeněk KALA, Markéta PROTIVÁNKOVÁ, Ondrej VYCITAL, Vaclav LISKA, Lucie SCHWARZOVA, Ludmila VODICKOVA a Pavel VODICKA. HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients. Carcinogenesis. Oxford: Oxford University Press, 2014, roč. 35, č. 7, s. 1510-1515. ISSN 0143-3334. Dostupné z: https://dx.doi.org/10.1093/carcin/bgu055. |
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@article{1173920,
author = {Svoboda, Miroslav and Slyskova, Jana and Schneiderova, Michaela and Makovicky, Peter and Bielik, Ludovit and Levy, Miroslav and Lipska, Ludmila and Hemmelová, Beáta and Kala, Zdeněk and Protivánková, Markéta and Vycital, Ondrej and Liska, Vaclav and Schwarzova, Lucie and Vodickova, Ludmila and Vodicka, Pavel},
article_location = {Oxford},
article_number = {7},
doi = {http://dx.doi.org/10.1093/carcin/bgu055},
keywords = {CARCINOMA PROGRESSION; GENOME},
language = {eng},
issn = {0143-3334},
journal = {Carcinogenesis},
title = {HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients},
volume = {35},
year = {2014}
}
TY - JOUR
ID - 1173920
AU - Svoboda, Miroslav - Slyskova, Jana - Schneiderova, Michaela - Makovicky, Peter - Bielik, Ludovit - Levy, Miroslav - Lipska, Ludmila - Hemmelová, Beáta - Kala, Zdeněk - Protivánková, Markéta - Vycital, Ondrej - Liska, Vaclav - Schwarzova, Lucie - Vodickova, Ludmila - Vodicka, Pavel
PY - 2014
TI - HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients
JF - Carcinogenesis
VL - 35
IS - 7
SP - 1510-1515
EP - 1510-1515
PB - Oxford University Press
SN - 01433334
KW - CARCINOMA PROGRESSION
KW - GENOME
N2 - Colorectal cancer (CRC) is one of the main causes of death of neoplasia. Demand for predictive and prognostic markers to reverse this trend is increasing. Long non-coding RNA HOTAIR (Homeobox Transcript Antisense Intergenic RNA) overexpression in tumors was previously associated with poor prognosis and higher mortality in different carcinomas. We analyzed HOTAIR expression levels in tumor and blood of incident sporadic CRC patients in relation to their overall survival with the aim to evaluate surrogate prognostic marker for CRC. Tissue donor group consisted of 73 CRC patients sampled for tumor and normal tissue. Blood donor group was represented by 84 CRC patients compared with 40 healthy controls. Patients were characterized for tumor-node-metastasis stage, tumor grade, microsatellite instability and tumor penetration by stromal cells. HOTAIR levels were assessed by real-time quantitative PCR. CRC patients had higher HOTAIR expression in blood than healthy controls (P = 0.0001), whereas there was no difference in HOTAIR levels between tumor and adjacent mucosa of CRC patients. HOTAIR levels positively correlated between blood and tumor (R = 0.43, P = 0.03). High HOTAIR levels in tumors were associated with higher mortality of patients [Cox’s proportional hazard, hazard ratio = 4.4, 95% confidence interval: 1.0–19.2, P = 0.046]. The hazard ratio was even higher when blood HOTAIR levels were taken into account (hazard ratio = 5.9, 95% confidence interval: 1.3–26.1, P = 0.019). Upregulated HOTAIR relative expression in primary tumors and in blood of CRC patients is associated with unfavorable prognosis. Our data suggest that HOTAIR blood levels may serve as potential surrogate prognostic marker in sporadic CRC.
ER -
SVOBODA, Miroslav, Jana SLYSKOVA, Michaela SCHNEIDEROVA, Peter MAKOVICKY, Ludovit BIELIK, Miroslav LEVY, Ludmila LIPSKA, Beáta HEMMELOVÁ, Zdeněk KALA, Markéta PROTIVÁNKOVÁ, Ondrej VYCITAL, Vaclav LISKA, Lucie SCHWARZOVA, Ludmila VODICKOVA a Pavel VODICKA. HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients. \textit{Carcinogenesis}. Oxford: Oxford University Press, 2014, roč.~35, č.~7, s.~1510-1515. ISSN~0143-3334. Dostupné z: https://dx.doi.org/10.1093/carcin/bgu055.
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