BAINOVÁ, Hana, Tereza KRÁLOVÁ, Anna BRYJOVÁ, Tomáš ALBRECHT, Josef BRYJA and Michal VINKLER. First evidence of independent pseudogenization of Toll-like receptor 5 in passerine birds. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY. England, 2014, vol. 45, No 1, p. 151-155. ISSN 0145-305X. Available from: https://dx.doi.org/10.1016/j.dci.2014.02.010. |
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@article{1180262, author = {Bainová, Hana and Králová, Tereza and Bryjová, Anna and Albrecht, Tomáš and Bryja, Josef and Vinkler, Michal}, article_location = {England}, article_number = {1}, doi = {http://dx.doi.org/10.1016/j.dci.2014.02.010}, keywords = {Birds; Expression; Innate immunity; Toll-like receptor 5; Pseudogene; Flagellin}, language = {eng}, issn = {0145-305X}, journal = {DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY}, title = {First evidence of independent pseudogenization of Toll-like receptor 5 in passerine birds}, volume = {45}, year = {2014} }
TY - JOUR ID - 1180262 AU - Bainová, Hana - Králová, Tereza - Bryjová, Anna - Albrecht, Tomáš - Bryja, Josef - Vinkler, Michal PY - 2014 TI - First evidence of independent pseudogenization of Toll-like receptor 5 in passerine birds JF - DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY VL - 45 IS - 1 SP - 151-155 EP - 151-155 SN - 0145305X KW - Birds KW - Expression KW - Innate immunity KW - Toll-like receptor 5 KW - Pseudogene KW - Flagellin N2 - Toll-like receptor 5 (TLR5) is a Pattern-recognition receptor responsible for microbial flagellin detection in vertebrates and, hence, recognition of potentially pathogenic bacteria. Herein, we report emergence of TLR5 pseudogene in several phylogenetic lineages of passerine birds (Aves: Passeriformes). Out of 47 species examined in this study 18 possessed a TLR5 pseudogene. Phylogenetic analysis together with the type of mutation responsible for pseudogenization indicate that TLR5 pseudogene emerged at least seven times independently in passerines. Lack of any functional copy of the gene has been verified based on TLR5 mRNA blood expression in four species representing the four main passerine lineages possessing the TLR5 pseudogene. Our results suggest that the non-functional TLR5 variant is fixed in those lineages or, at least, that individuals homozygote in the TLR5 pseudogene are frequent in the investigated species. Further research is needed to assess the impact of the TLR5 loss on immunological performance in birds. ER -
BAINOVÁ, Hana, Tereza KRÁLOVÁ, Anna BRYJOVÁ, Tomáš ALBRECHT, Josef BRYJA and Michal VINKLER. First evidence of independent pseudogenization of Toll-like receptor 5 in passerine birds. \textit{DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY}. England, 2014, vol.~45, No~1, p.~151-155. ISSN~0145-305X. Available from: https://dx.doi.org/10.1016/j.dci.2014.02.010.
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