Ribozyme Activity of RNA Nonenzymatically Polymerized from 3
',5 '-Cyclic GMP

J 2013

Ribozyme Activity of RNA Nonenzymatically Polymerized from 3 ',5 '-Cyclic GMP

PINO, Samanta, Giovanna COSTANZO, Alessandra GIORGI, Jiří ŠPONER, Judit ŠPONEROVÁ et. al.

Základní údaje

Originální název

Ribozyme Activity of RNA Nonenzymatically Polymerized from 3 ',5 '-Cyclic GMP

Autoři

PINO, Samanta (380 Itálie), Giovanna COSTANZO (380 Itálie), Alessandra GIORGI (380 Itálie), Jiří ŠPONER (203 Česká republika, garant, domácí), Judit ŠPONEROVÁ (348 Maďarsko, domácí) a Ernesto DI MAURO (380 Itálie)

Vydání

Entropy, Basel, MDPI AG, 2013, 1099-4300

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10610 Biophysics

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.564

Kód RIV

RIV/00216224:14740/13:00073063

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.3390/e15125362

UT WoS

000330339700014

Klíčová slova anglicky

RNA; RNA polymerization; RNA origin; ribozymes; origin of life

Štítky

ok, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 25. 4. 2014 20:52, Olga Křížová

Anotace

V originále

3',5'-Cyclic GMP spontaneously nonenzymatically polymerizes in a base-catalyzed reaction affording G oligonucleotides. When reacted with fully or partially sequence-complementary RNA (oligo C), the abiotically generated oligo G RNA displays a typical ribozyme activity consisting of terminal ligation accompanied by cleavage of an internal phosphate site of the donor oligonucleotide stem upon attack of the acceptor 3' terminal OH. This reaction is dubbed Ligation following Intermolecular Cleavage (LIC). In a prebiotic perspective, the ability of oligo G polynucleotides to react with other sequences outlines a simple and possible evolutionary scenario based on the autocatalytic properties of RNA.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

Citovat

PINO, Samanta, Giovanna COSTANZO, Alessandra GIORGI, Jiří ŠPONER, Judit ŠPONEROVÁ a Ernesto DI MAURO. Ribozyme Activity of RNA Nonenzymatically Polymerized from 3 ',5 '-Cyclic GMP. Entropy. Basel: MDPI AG, 2013, roč. 15, č. 12, s. 5362-5383. ISSN 1099-4300. Dostupné z: https://dx.doi.org/10.3390/e15125362.

@article{1180347,
   author = {Pino, Samanta and Costanzo, Giovanna and Giorgi, Alessandra and Šponer, Jiří and Šponerová, Judit and Di Mauro, Ernesto},
   article_location = {Basel},
   article_number = {12},
   doi = {http://dx.doi.org/10.3390/e15125362},
   keywords = {RNA; RNA polymerization; RNA origin; ribozymes; origin of life},
   language = {eng},
   issn = {1099-4300},
   journal = {Entropy},
   title = {Ribozyme Activity of RNA Nonenzymatically Polymerized from 3 ',5 '-Cyclic GMP},
   url = {http://www.mdpi.com/1099-4300/15/12/5362},
   volume = {15},
   year = {2013}
}

TY  - JOUR
ID  - 1180347
AU  - Pino, Samanta - Costanzo, Giovanna - Giorgi, Alessandra - Šponer, Jiří - Šponerová, Judit - Di Mauro, Ernesto
PY  - 2013
TI  - Ribozyme Activity of RNA Nonenzymatically Polymerized from 3 ',5 '-Cyclic GMP
JF  - Entropy
VL  - 15
IS  - 12
SP  - 5362-5383
EP  - 5362-5383
PB  - MDPI AG
SN  - 10994300
KW  - RNA
KW  - RNA polymerization
KW  - RNA origin
KW  - ribozymes
KW  - origin of life
UR  - http://www.mdpi.com/1099-4300/15/12/5362
L2  - http://www.mdpi.com/1099-4300/15/12/5362
N2  - 3',5'-Cyclic GMP spontaneously nonenzymatically polymerizes in a base-catalyzed reaction affording G oligonucleotides. When reacted with fully or partially sequence-complementary RNA (oligo C), the abiotically generated oligo G RNA displays a typical ribozyme activity consisting of terminal ligation accompanied by cleavage of an internal phosphate site of the donor oligonucleotide stem upon attack of the acceptor 3' terminal OH. This reaction is dubbed Ligation following Intermolecular Cleavage (LIC). In a prebiotic perspective, the ability of oligo G polynucleotides to react with other sequences outlines a simple and possible evolutionary scenario based on the autocatalytic properties of RNA.
ER  -

PINO, Samanta, Giovanna COSTANZO, Alessandra GIORGI, Jiří ŠPONER, Judit ŠPONEROVÁ a Ernesto DI MAURO. Ribozyme Activity of RNA Nonenzymatically Polymerized from 3 ',5 '-Cyclic GMP. \textit{Entropy}. Basel: MDPI AG, 2013, roč.~15, č.~12, s.~5362-5383. ISSN~1099-4300. Dostupné z: https://dx.doi.org/10.3390/e15125362.

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