Implication of NMDA receptors in behavioural sensitization to
psychostimulants: A short review

J 2014

Implication of NMDA receptors in behavioural sensitization to psychostimulants: A short review

LANDA, Leoš, Alena MÁCHALOVÁ and Alexandra ŠULCOVÁ

Basic information

Original name

Implication of NMDA receptors in behavioural sensitization to psychostimulants: A short review

Authors

LANDA, Leoš (203 Czech Republic), Alena MÁCHALOVÁ (203 Czech Republic, belonging to the institution) and Alexandra ŠULCOVÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

European Journal of Pharmacology, Amsterdam, Elsevier Science, 2014, 0014-2999

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.532

RIV identification code

RIV/00216224:14740/14:00075340

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1016/j.ejphar.2014.02.028

UT WoS

000333763900012

Keywords in English

Animal models; Behavioural sensitization; NMDA receptor; Psychostimulants

Abstract

V originále

Repeated administration of psychostimulants and other dependence-producing substances induces a substantial increase in behavioural responses, a phenomenon termed as behavioural sensitization. An increased response to the tested drug elicited by previous repeated administration of a different drug is called cross-sensitization. Behavioural sensitization is considered to be a relapse trigger in dependent subjects and animals sensitized by repeated administration of drugs of abuse, thus being considered a suitable model of craving, which is one of the very characteristic features of substance addiction. It has been described that apart from other actions, drugs of abuse exert their effect on the central nervous system by affecting glutamatergic transmissions, particularly via N-methyl-d-aspartate (NMDA) receptors. Thus, this review presents a brief overview of the impact of inhibition of the NMDA receptor system on sensitization, reflecting particularly on behavioural sensitization to sychostimulants. The text combines up-to-date information with time-proven facts and also compares data from the literature with the authors? recent findings concerning this topic.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

Citovat

LANDA, Leoš, Alena MÁCHALOVÁ and Alexandra ŠULCOVÁ. Implication of NMDA receptors in behavioural sensitization to psychostimulants: A short review. European Journal of Pharmacology. Amsterdam: Elsevier Science, 2014, vol. 730, May, p. 77-81. ISSN 0014-2999. Available from: https://dx.doi.org/10.1016/j.ejphar.2014.02.028.

@article{1180400,
   author = {Landa, Leoš and Máchalová, Alena and Šulcová, Alexandra},
   article_location = {Amsterdam},
   article_number = {May},
   doi = {http://dx.doi.org/10.1016/j.ejphar.2014.02.028},
   keywords = {Animal models; Behavioural sensitization; NMDA receptor; Psychostimulants},
   language = {eng},
   issn = {0014-2999},
   journal = {European Journal of Pharmacology},
   title = {Implication of NMDA receptors in behavioural sensitization to psychostimulants: A short review},
   url = {http://www.sciencedirect.com/science/article/pii/S0014299914001666#},
   volume = {730},
   year = {2014}
}

TY  - JOUR
ID  - 1180400
AU  - Landa, Leoš - Máchalová, Alena - Šulcová, Alexandra
PY  - 2014
TI  - Implication of NMDA receptors in behavioural sensitization to psychostimulants: A short review
JF  - European Journal of Pharmacology
VL  - 730
IS  - May
SP  - 77-81
EP  - 77-81
PB  - Elsevier Science
SN  - 00142999
KW  - Animal models
KW  - Behavioural sensitization
KW  - NMDA receptor
KW  - Psychostimulants
UR  - http://www.sciencedirect.com/science/article/pii/S0014299914001666#
L2  - http://www.sciencedirect.com/science/article/pii/S0014299914001666#
N2  - Repeated administration of psychostimulants and other dependence-producing substances induces a substantial increase in behavioural responses, a phenomenon termed as behavioural sensitization. An increased response to the tested drug elicited by previous repeated administration of a different drug is called cross-sensitization. Behavioural sensitization is considered to be a relapse trigger in dependent subjects and animals sensitized by repeated administration of drugs of abuse, thus being considered a suitable model of craving, which is one of the very characteristic features of substance addiction. It has been described that apart from other actions, drugs of abuse exert their effect on the central nervous system by affecting glutamatergic transmissions, particularly via N-methyl-d-aspartate (NMDA) receptors. Thus, this review presents a brief overview of the impact of inhibition of the NMDA receptor system on sensitization, reflecting particularly on behavioural sensitization to sychostimulants. The text combines up-to-date information with time-proven facts and also compares data from the literature with the authors? recent findings concerning this topic.
ER  -

LANDA, Leoš, Alena MÁCHALOVÁ and Alexandra ŠULCOVÁ. Implication of NMDA receptors in behavioural sensitization to psychostimulants: A short review. \textit{European Journal of Pharmacology}. Amsterdam: Elsevier Science, 2014, vol.~730, May, p.~77-81. ISSN~0014-2999. Available from: https://dx.doi.org/10.1016/j.ejphar.2014.02.028.

Detailed Information on Publication Record