The effect of the cannabinoid CB1 receptor agonist
arachidonylcyclopropylamide (ACPA) on behavioural sensitisation
to methamphetamine in mice

J 2014

The effect of the cannabinoid CB1 receptor agonist arachidonylcyclopropylamide (ACPA) on behavioural sensitisation to methamphetamine in mice

LANDA, Leoš, Karel ŠLAIS, Alena MÁCHALOVÁ a Alexandra ŠULCOVÁ

Základní údaje

Originální název

The effect of the cannabinoid CB1 receptor agonist arachidonylcyclopropylamide (ACPA) on behavioural sensitisation to methamphetamine in mice

Autoři

LANDA, Leoš (203 Česká republika), Karel ŠLAIS (203 Česká republika, domácí), Alena MÁCHALOVÁ (203 Česká republika, domácí) a Alexandra ŠULCOVÁ (203 Česká republika, garant, domácí)

Vydání

Veterinární medicína, Praha, CZECH ACADEMY AGRICULTURAL SCIENCES, 2014, 0375-8427

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 0.639

Kód RIV

RIV/00216224:14740/14:00075341

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1016/j.ejphar.2014.02.028

UT WoS

000339609700005

Klíčová slova anglicky

behavioural sensitisation; methamphetamine; cannabinoids; ACPA; mice

Štítky

kontrola MP, ok, rivok, SCOPUS

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 28. 8. 2015 07:31, Olga Křížová

Anotace

V originále

The psychostimulant methamphetamine (Met), similarly to other drugs of abuse, is known to pro-duce an increased behavioural response after its repeated application (behavioural sensitisation). It has also been described that an increased response to a drug may be elicited by previous repeated administration of another drug (cross-sensitisation). We have previously shown that the CB1, CB2 and TRPV (vanilloid) cannabinoid receptor agonist methanandamide, cross-sensitised to Met stimulatory effects in mice. The present study was focused on ability of the more selective and potent CB1 receptor activator arachidonylcyclopropylamide (ACPA) to elicit cross-sensitisation to the stimulatory effects of Met on mouse locomotor behaviour in the Open field test. Male mice were randomly divided into three groups and on seven occasions (from the 7th to 13th day of the experiment) were administered drugs as follows:(a) n1: vehicle at the dose of 10 ml/kg/day; (b) n2: Met at the dose of 2.5 mg/kg/day; (c) n 3: ACPA at the dose of 1.0 mg/kg/day. Locomotor behaviour in the Open field test was measured (a) after administration of vehicle on the 1st experimental day, (b) after the 1st dose of drugs given on the 7th day, and (c) on the 14th day after drugs as follows:(a) n1: vehicle at the dose of 10 ml/kg/day; (b) n2: Met at the dose of 2.5 mg/kg/day; (c) n 3: ACPA at the dose of 1.0 mg/kg/day.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

Citovat

LANDA, Leoš, Karel ŠLAIS, Alena MÁCHALOVÁ a Alexandra ŠULCOVÁ. The effect of the cannabinoid CB1 receptor agonist arachidonylcyclopropylamide (ACPA) on behavioural sensitisation to methamphetamine in mice. Veterinární medicína. Praha: CZECH ACADEMY AGRICULTURAL SCIENCES, 2014, roč. 59, č. 2, s. 88-94. ISSN 0375-8427. Dostupné z: https://dx.doi.org/10.1016/j.ejphar.2014.02.028.

@article{1180401,
   author = {Landa, Leoš and Šlais, Karel and Máchalová, Alena and Šulcová, Alexandra},
   article_location = {Praha},
   article_number = {2},
   doi = {http://dx.doi.org/10.1016/j.ejphar.2014.02.028},
   keywords = {behavioural sensitisation; methamphetamine; cannabinoids; ACPA; mice},
   language = {eng},
   issn = {0375-8427},
   journal = {Veterinární medicína},
   title = {The effect of the cannabinoid CB1 receptor agonist arachidonylcyclopropylamide (ACPA) on behavioural sensitisation to methamphetamine in mice},
   url = {http://vri.cz/docs/vetmed/59-2-88.pdf},
   volume = {59},
   year = {2014}
}

TY  - JOUR
ID  - 1180401
AU  - Landa, Leoš - Šlais, Karel - Máchalová, Alena - Šulcová, Alexandra
PY  - 2014
TI  - The effect of the cannabinoid CB1 receptor agonist arachidonylcyclopropylamide (ACPA) on behavioural sensitisation to methamphetamine in mice
JF  - Veterinární medicína
VL  - 59
IS  - 2
SP  - 88-94
EP  - 88-94
PB  - CZECH ACADEMY AGRICULTURAL SCIENCES
SN  - 03758427
KW  - behavioural sensitisation
KW  - methamphetamine
KW  - cannabinoids
KW  - ACPA
KW  - mice
UR  - http://vri.cz/docs/vetmed/59-2-88.pdf
L2  - http://vri.cz/docs/vetmed/59-2-88.pdf
N2  - The psychostimulant methamphetamine (Met), similarly to other drugs of abuse, is known to pro-duce an increased behavioural response after its repeated application (behavioural sensitisation). It has also been described that an increased response to a drug may be elicited by previous repeated administration of another drug (cross-sensitisation). We have previously shown that the CB1, CB2 and TRPV (vanilloid) cannabinoid receptor agonist methanandamide, cross-sensitised to Met stimulatory effects in mice. The present study was focused on ability of the more selective and potent CB1 receptor activator arachidonylcyclopropylamide (ACPA) to elicit cross-sensitisation to the stimulatory effects of Met on mouse locomotor behaviour in the Open field test. Male mice were randomly divided into three groups and on seven occasions (from the 7th to 13th day of the experiment) were administered drugs as follows:(a) n1: vehicle at the dose of 10 ml/kg/day; (b) n2: Met at the dose of 2.5 mg/kg/day; (c) n 3: ACPA at the dose of 1.0 mg/kg/day. Locomotor behaviour in the Open field test was measured (a) after administration of vehicle on the 1st experimental day, (b) after the 1st dose of drugs given on the 7th day, and (c) on the 14th day after drugs as follows:(a) n1: vehicle at the dose of 10 ml/kg/day; (b) n2: Met at the dose of 2.5 mg/kg/day; (c) n 3: ACPA at the dose of 1.0 mg/kg/day.
ER  -

LANDA, Leoš, Karel ŠLAIS, Alena MÁCHALOVÁ a Alexandra ŠULCOVÁ. The effect of the cannabinoid CB1 receptor agonist arachidonylcyclopropylamide (ACPA) on behavioural sensitisation to methamphetamine in mice. \textit{Veterinární medicína}. Praha: CZECH ACADEMY AGRICULTURAL SCIENCES, 2014, roč.~59, č.~2, s.~88-94. ISSN~0375-8427. Dostupné z: https://dx.doi.org/10.1016/j.ejphar.2014.02.028.

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