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@article{1180911,
author = {Nártová, Eva and Kraus, Jaroslav and Pavlík, Emil and Lukeš, Petr and Katra, Rami and Plzák, Jan and Kolářová, Libuše and Šterzl, Ivan and Betka, Jan and Astl, Jaromír},
article_location = {NEW YORK},
article_number = {3},
doi = {http://dx.doi.org/10.1007/s00405-013-2607-9},
keywords = {Helicobacter pylori; Tonsillar tissue; Sleep apnoea syndrome; Real-time PCR; Hybridisation probes},
language = {eng},
issn = {0937-4477},
journal = {European Archives of Oto-Rhino-Laryngology and Head & Neck},
title = {Presence of different genotypes of Helicobacter pylori in patients with chronic tonsillitis and sleep apnoea syndrome},
volume = {271},
year = {2014}
}
TY - JOUR
ID - 1180911
AU - Nártová, Eva - Kraus, Jaroslav - Pavlík, Emil - Lukeš, Petr - Katra, Rami - Plzák, Jan - Kolářová, Libuše - Šterzl, Ivan - Betka, Jan - Astl, Jaromír
PY - 2014
TI - Presence of different genotypes of Helicobacter pylori in patients with chronic tonsillitis and sleep apnoea syndrome
JF - European Archives of Oto-Rhino-Laryngology and Head & Neck
VL - 271
IS - 3
SP - 607-613
EP - 607-613
PB - SPRINGER
SN - 09374477
KW - Helicobacter pylori
KW - Tonsillar tissue
KW - Sleep apnoea syndrome
KW - Real-time PCR
KW - Hybridisation probes
N2 - Helicobacter pylori, a well-known gastric pathogen, has been detected in the oral cavity and oropharynx in tonsillar tissue. In our study, the presence of H. pylori in the tonsillar tissue of patients with chronic tonsillitis and sleep apnoea syndrome (SAS) was investigated. The aim was to detect and genotype H. pylori for a collection of data supporting the possible role of H. pylori in the aetiology of chronic tonsillitis and SAS. Helicobacter pylori was detected by real-time polymerase chain reaction (rt-PCR). 89 patients, 60 with a diagnosis of chronic tonsillitis and 29 with SAS, were tested. In the chronic tonsillitis group, Helicobacter was detected in 48 (80 %) specimens, cagA gene was detected in 12 samples (25 %) and 12 samples were negative. In SAS group, Helicobacter was found in 24 samples (82.76 %), cagA gene was detected in 5 (20.83 %) and 5 samples (17.24 %) were negative. Helicobacter pylori-specific immunoglobulins were tested by ELISA in the serum of 57 patients only with 41 (71.93 %) showing positive. Our results on H. pylori DNA detection and H. pylori seropositivity show 26.32 % discrepancy, slightly in favour of rt-PCR (15.79 % compared to 10.53 %). The H. pylori presence in tonsillar tissue does not depend on the type of oropharyngeal disease (p = 0.756). This study shows that oropharynx constitutes an extragastric reservoir of H. pylori infection which could serve as an aetiopathogenetic factor for chronic tonsillitis and tonsillar hyperplasia by SAS. No conclusion has yet been drawn about the mechanism of the process.
ER -
NÁRTOVÁ, Eva, Jaroslav KRAUS, Emil PAVLÍK, Petr LUKEŠ, Rami KATRA, Jan PLZÁK, Libuše KOLÁŘOVÁ, Ivan ŠTERZL, Jan BETKA a Jaromír ASTL. Presence of different genotypes of Helicobacter pylori in patients with chronic tonsillitis and sleep apnoea syndrome. \textit{European Archives of Oto-Rhino-Laryngology and Head \&{} Neck}. NEW YORK: SPRINGER, 2014, roč.~271, č.~3, s.~607-613. ISSN~0937-4477. Dostupné z: https://dx.doi.org/10.1007/s00405-013-2607-9.
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