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@article{1181713, author = {Aćimović, Ivana and Vilotić, Aleksandra and Pešl, Martin and Lacampagne, Alain and Dvořák, Petr and Rotrekl, Vladimír and Meli, Albano}, article_location = {USA}, article_number = {"512831"}, doi = {http://dx.doi.org/10.1155/2014/512831}, keywords = {human pluripotent stem cell; differentiation; cardiomyocyte; calcium; disease model}, language = {eng}, issn = {2314-6133}, journal = {BioMed Research International}, title = {Human Pluripotent Stem Cell-Derived Cardiomyocytes as Research and Therapeutic Tools}, url = {http://downloads.hindawi.com/journals/bmri/2014/512831.pdf}, volume = {2014}, year = {2014} }
TY - JOUR ID - 1181713 AU - Aćimović, Ivana - Vilotić, Aleksandra - Pešl, Martin - Lacampagne, Alain - Dvořák, Petr - Rotrekl, Vladimír - Meli, Albano PY - 2014 TI - Human Pluripotent Stem Cell-Derived Cardiomyocytes as Research and Therapeutic Tools JF - BioMed Research International VL - 2014 IS - "512831" SP - 1-14 EP - 1-14 PB - Hindawi Publishing Corporation SN - 23146133 KW - human pluripotent stem cell KW - differentiation KW - cardiomyocyte KW - calcium KW - disease model UR - http://downloads.hindawi.com/journals/bmri/2014/512831.pdf N2 - Human pluripotent stem cells (hPSCs), namely, embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), with their ability of indefinite self-renewal and capability to differentiate into cell types derivatives of all three germlayers, represent a powerful research tool in developmental biology, for drug screening, disease modelling, and potentially cell replacement therapy. Efficient differentiation protocols that would result in the cell type of our interest are needed for maximal exploitation of these cells. In the present work, we aim at focusing on the protocols for differentiation of hPSCs into functional cardiomyocytes in vitro as well as achievements in the heart disease modelling and drug testing on the patient-specific iPSC-derived cardiomyocytes (iPSC-CMs). ER -
A$\backslash$'CIMOVI$\backslash$'C, Ivana, Aleksandra VILOTI$\backslash$'C, Martin PEŠL, Alain LACAMPAGNE, Petr DVOŘÁK, Vladimír ROTREKL a Albano MELI. Human Pluripotent Stem Cell-Derived Cardiomyocytes as Research and Therapeutic Tools. \textit{BioMed Research International}. USA: Hindawi Publishing Corporation, 2014, roč.~2014, ''512831'', s.~1-14. ISSN~2314-6133. Dostupné z: https://dx.doi.org/10.1155/2014/512831.
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