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@article{1182703,
author = {Meluzín, Jaroslav and Hude, Petr and Leinveber, Pavel and Jurak, Pavel and Soukup, Ladislav and Viscor, Ivo and Špinarová, Lenka and Stepanova, Radka and Podrouzkova, Helena and Vondra, Vlastimil and Langer, Peter and Nemec, Pavel},
article_number = {1},
keywords = {Bioimpedance; Exercise tolerance; Heart failure; Stroke volume index},
language = {eng},
issn = {1205-6626},
journal = {EXPERIMENTAL & CLINICAL CARDIOLOGY},
title = {The magnitude and course of exercise-induced stroke volume changes determine the exercise tolerance in heart transplant recipients with heart failure and normal ejection fraction},
volume = {20},
year = {2014}
}
TY - JOUR
ID - 1182703
AU - Meluzín, Jaroslav - Hude, Petr - Leinveber, Pavel - Jurak, Pavel - Soukup, Ladislav - Viscor, Ivo - Špinarová, Lenka - Stepanova, Radka - Podrouzkova, Helena - Vondra, Vlastimil - Langer, Peter - Nemec, Pavel
PY - 2014
TI - The magnitude and course of exercise-induced stroke volume changes determine the exercise tolerance in heart transplant recipients with heart failure and normal ejection fraction
JF - EXPERIMENTAL & CLINICAL CARDIOLOGY
VL - 20
IS - 1
SP - 674-687
EP - 674-687
PB - Pulsus Group Inc.
SN - 12056626
KW - Bioimpedance
KW - Exercise tolerance
KW - Heart failure
KW - Stroke volume index
N2 - Objectives: There is a large variability of exercise-induced stroke volume behavior in healthy subjects. We sought to assess the course of exercise-induced changes in stroke volume index (SVI) and other functional parameters in post-heart transplant patients with heart failure and normal left ventricular ejection fraction (HFNEF). Methods: Left ventricular function and systemic hemodynamics were assessed at 40 s intervals during the exercise in 39 patients using simultaneous right heart catheterization, bioimpedance, and echocardiography. Results: Twenty-six patients had exercise tolerance >/= 4.0 METs (Group A), while 13 patients exhibited severely limited exercise tolerance < 4 METs (Group B). Maximal SVI (maxSVI) achieved at any time during the exercise exceeded SVI at peak exercise (peakSVI) in 26 patients (67%). Both maxSVI and maxSVI (maxSVI minus SVI at rest) were significantly higher in Group A compared to Group B patients (59 ml/m2 vs 41 ml/m 2, p < 0.01, and 21 ml/m2 vs 6 ml/m2, p < 0.01, respectively). With peakSVI, maxSVI, peakSVI, maxSVI and other variables evaluated, only maxSVI was independently associated with exercise tolerance. Conclusion: When assessing exercise-induced SVI changes in HFNEF patients, SVI should be followed during the course of exercise and maximal SVI change from rest should always be determined.
ER -
MELUZÍN, Jaroslav, Petr HUDE, Pavel LEINVEBER, Pavel JURAK, Ladislav SOUKUP, Ivo VISCOR, Lenka ŠPINAROVÁ, Radka STEPANOVA, Helena PODROUZKOVA, Vlastimil VONDRA, Peter LANGER a Pavel NEMEC. The magnitude and course of exercise-induced stroke volume changes determine the exercise tolerance in heart transplant recipients with heart failure and normal ejection fraction. \textit{EXPERIMENTAL \&{} CLINICAL CARDIOLOGY}. Pulsus Group Inc., 2014, roč.~20, č.~1, s.~674-687. ISSN~1205-6626.
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