Detailed Information on Publication Record
2014
Adipose Tissue Endocrine Regulations in Metabolic Syndrome and Appetite
KOTOLOVÁ, Hana, Kateřina HORSKÁ and Jana KUČEROVÁBasic information
Original name
Adipose Tissue Endocrine Regulations in Metabolic Syndrome and Appetite
Name in Czech
Endokrinní regulace tukové tkáně u metabolického syndromu a chuti k jídlu
Authors
KOTOLOVÁ, Hana (203 Czech Republic), Kateřina HORSKÁ (203 Czech Republic) and Jana KUČEROVÁ (203 Czech Republic, guarantor, belonging to the institution)
Edition
New York, Appetite: Regulation, Use of Stimulants and Cultural and Biological Influences, p. 97-122, 26 pp. Human Anatomy and Physiology, 2014
Publisher
Nova Science Publishers
Other information
Language
English
Type of outcome
Kapitola resp. kapitoly v odborné knize
Field of Study
30104 Pharmacology and pharmacy
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
Publication form
electronic version available online
RIV identification code
RIV/00216224:14110/14:00075512
Organization unit
Faculty of Medicine
ISBN
978-1-63117-243-4
Keywords (in Czech)
metabolický syndrom; adipokiny; leptin; adiponektin; resistin; AFABP
Keywords in English
metabolic syndrome; adipokines; leptin; adiponectin; resistin; AFABP
Tags
Tags
International impact
Změněno: 13/7/2020 10:03, Mgr. Tereza Miškechová
Abstract
V originále
The current worldwide epidemic of metabolic syndrome represents an urgent challenge for new pharmacotherapy development. There is growing evidence of multiple metabolic dysregulations contributing to the development of the pathophysiological processes underlying metabolic syndrome. The adipose tissue metabolism and its endocrine activity is one of the key mechanisms believed to provide new targets for pharmacotherapy. The aim of this chapter is to provide a survey on metabolic syndrome pathophysiology, etiology and hypotheses of its development with special attention focused on insulin resistance, inflammatory processes and endocrine activity of the adipose tissue. Specific adipokines secreted by the body fat have multiple effects on the energy metabolism and can either support or suppress insulin signaling. Their pharmacological exploitation may lead to development of new treatments of insulin resistance and metabolic syndrome. Furthermore, possible common underlying processes between appetite regulation and metabolic syndrome pathophysiology are discussed.