| KUBICZKOVÁ, Lenka, Fedor KRYUKOV, Ondřej SLABÝ, Elena Vladimirovna KRYUKOVA, Jiří JARKOVSKÝ, Jana NEKVINDOVÁ, Lenka RADOVÁ, Henrieta GREŠLIKOVÁ, Petr KUGLÍK, Eva VETEŠNÍKOVÁ, Luděk POUR, Zdeněk ADAM, Sabina ŠEVČÍKOVÁ and Roman HÁJEK. Circulating serum microRNAs as novel diagnostic and prognostic biomarkers for multiple myeloma and monoclonal gammopathy of undetermined significance. Haematologica/the hematology journal. Pavia: Fondazione Ferrata Storti, 2014, vol. 99, No 3, p. 511-518. ISSN 0390-6078. Available from: https://dx.doi.org/10.3324/haematol.2013.093500. |
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@article{1183185,
author = {Kubiczková, Lenka and Kryukov, Fedor and Slabý, Ondřej and Kryukova, Elena Vladimirovna and Jarkovský, Jiří and Nekvindová, Jana and Radová, Lenka and Grešliková, Henrieta and Kuglík, Petr and Vetešníková, Eva and Pour, Luděk and Adam, Zdeněk and Ševčíková, Sabina and Hájek, Roman},
article_location = {Pavia},
article_number = {3},
doi = {http://dx.doi.org/10.3324/haematol.2013.093500},
keywords = {Multiple myeloma; MGUS; circulating miRNA; miRNA profiling; qPCR},
language = {eng},
issn = {0390-6078},
journal = {Haematologica/the hematology journal},
title = {Circulating serum microRNAs as novel diagnostic and prognostic biomarkers for multiple myeloma and monoclonal gammopathy of undetermined significance},
volume = {99},
year = {2014}
}
TY - JOUR
ID - 1183185
AU - Kubiczková, Lenka - Kryukov, Fedor - Slabý, Ondřej - Kryukova, Elena Vladimirovna - Jarkovský, Jiří - Nekvindová, Jana - Radová, Lenka - Grešliková, Henrieta - Kuglík, Petr - Vetešníková, Eva - Pour, Luděk - Adam, Zdeněk - Ševčíková, Sabina - Hájek, Roman
PY - 2014
TI - Circulating serum microRNAs as novel diagnostic and prognostic biomarkers for multiple myeloma and monoclonal gammopathy of undetermined significance
JF - Haematologica/the hematology journal
VL - 99
IS - 3
SP - 511-518
EP - 511-518
PB - Fondazione Ferrata Storti
SN - 03906078
KW - Multiple myeloma
KW - MGUS
KW - circulating miRNA
KW - miRNA profiling
KW - qPCR
N2 - Multiple myeloma still remains incurable in majority of cases prompting further search for new and better prognostic markers. Emerging evidence has suggested that circulating microRNAs can serve as minimally invasive biomarkers for multiple myeloma and monoclonal gammopathy of undetermined significance. In this study, a global analysis of serum microRNAs by TaqMan Low Density arrays was performed, followed by quantitative real-time PCR. The analyses revealed five deregulated microRNAs: miR-744, miR-130a, miR-34a, let-7d and let-7e in monoclonal gammopathy of undetermined significance, newly diagnosed and relapsed multiple myeloma when compared to healthy donors. Multivariate logistic regression analysis showed that combination of miR-34a and let-7e can distinguish multiple myeloma from healthy donors with sensitivity 80.6% and specificity 86.7% and monoclonal gammopathy of undetermined significance from healthy donors with sensitivity 91.1% and specificity 96.7%. Furthermore, lower levels of miR-744 and let-7e were associated with shorter overall survival and remission of myeloma patients. One-year mortality rate for miR-744 and let-7e was 41.9% and 34.6% for ’low’ expression and 3.3% and 3.9% for ’high’ expression group, respectively. Median time of remission for both miR- 744 and let-7e was ~11 months for ’low’ expression and ~47 months for ’high’ expression groups of myeloma patients These data demonstrate that expression patterns of circulating microRNAs are altered in multiple myeloma and monoclonal gammopathy of undetermined significance and miR-744 with let-7e are associated with survival of myeloma patients.
ER -
KUBICZKOVÁ, Lenka, Fedor KRYUKOV, Ondřej SLABÝ, Elena Vladimirovna KRYUKOVA, Jiří JARKOVSKÝ, Jana NEKVINDOVÁ, Lenka RADOVÁ, Henrieta GREŠLIKOVÁ, Petr KUGLÍK, Eva VETEŠNÍKOVÁ, Luděk POUR, Zdeněk ADAM, Sabina ŠEVČÍKOVÁ and Roman HÁJEK. Circulating serum microRNAs as novel diagnostic and prognostic biomarkers for multiple myeloma and monoclonal gammopathy of undetermined significance. \textit{Haematologica/the hematology journal}. Pavia: Fondazione Ferrata Storti, 2014, vol.~99, No~3, p.~511-518. ISSN~0390-6078. Available from: https://dx.doi.org/10.3324/haematol.2013.093500.
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