J 2014

HPV typing of high-grade dysplasia (CIN III) in cone biopsies of 38 HPV-vaccinated women

ONDIČ, Ondrej, Jana KAŠPÍRKOVÁ, Ondřej MÁJEK and Iva KINKOROVÁ

Basic information

Original name

HPV typing of high-grade dysplasia (CIN III) in cone biopsies of 38 HPV-vaccinated women

Authors

ONDIČ, Ondrej (203 Czech Republic), Jana KAŠPÍRKOVÁ (203 Czech Republic), Ondřej MÁJEK (203 Czech Republic, guarantor, belonging to the institution) and Iva KINKOROVÁ (203 Czech Republic)

Edition

Virchows Archiv, New York, Springer, 2014, 0945-6317

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.651

RIV identification code

RIV/00216224:14110/14:00075524

Organization unit

Faculty of Medicine

DOI

UT WoS

000329836700011

Keywords in English

Cervix; Dysplasia; CIN III; HPV; Vaccination

Tags

Tags

International impact, Reviewed
Změněno: 21/5/2014 11:09, Soňa Böhmová

Abstract

V originále

HPV-vaccinated women develop CIN III very rarely. We have identified a study group of 38 such patients and showed that a specific HPV genotype prevalence in those cases equals the prevalence of HPV genotypes in CIN III present in the general Czech population. In all cases, CIN III was diagnosed within 3 years after having completed the HPV vaccination. We conclude that dysplasia was present before the vaccination in those women. A history of abnormal pre-vaccination PAP smear result (present in 78 % of women in the study group) and age of over 17 by the time of vaccination completion (97 % of women in the study group) are identified as probable factors increasing the risk of CIN III development after HPV vaccination.