ROSOLOVA, Hana, Milada DOBIASOVA, Vladimír SOŠKA, Vladimir BLAHA, Richard CESKA, Barbora NUSSBAUMEROVA, Terezie PELIKANOVA a Miroslav SOUČEK. Combined therapy of mixed dyslipidemia in patients with high cardiovascular risk and changes in the lipid target values and atherogenic index of plasma. Cor et Vasa. Brno: Česká kardiologická společnost, 2014, roč. 56, č. 2, s. "e133-e139", 7 s. ISSN 0010-8650. Dostupné z: https://dx.doi.org/10.1016/j.crvasa.2014.01.003. |
Další formáty:
BibTeX
LaTeX
RIS
@article{1184607, author = {Rosolova, Hana and Dobiasova, Milada and Soška, Vladimír and Blaha, Vladimir and Ceska, Richard and Nussbaumerova, Barbora and Pelikanova, Terezie and Souček, Miroslav}, article_location = {Brno}, article_number = {2}, doi = {http://dx.doi.org/10.1016/j.crvasa.2014.01.003}, keywords = {AIP = log[triglycerides/ HDL-cholesterol]); Atherogenic index of plasma; Combined lipid-modifying therapy; Mixed dyslipidemia}, language = {eng}, issn = {0010-8650}, journal = {Cor et Vasa}, title = {Combined therapy of mixed dyslipidemia in patients with high cardiovascular risk and changes in the lipid target values and atherogenic index of plasma}, volume = {56}, year = {2014} }
TY - JOUR ID - 1184607 AU - Rosolova, Hana - Dobiasova, Milada - Soška, Vladimír - Blaha, Vladimir - Ceska, Richard - Nussbaumerova, Barbora - Pelikanova, Terezie - Souček, Miroslav PY - 2014 TI - Combined therapy of mixed dyslipidemia in patients with high cardiovascular risk and changes in the lipid target values and atherogenic index of plasma JF - Cor et Vasa VL - 56 IS - 2 SP - "e133-e139" EP - "e133-e139" PB - Česká kardiologická společnost SN - 00108650 KW - AIP = log[triglycerides/ HDL-cholesterol]) KW - Atherogenic index of plasma KW - Combined lipid-modifying therapy KW - Mixed dyslipidemia N2 - Purpose: To evaluate the safety and efficacy of combined lipid-modifying agents (statin + fenofibrate) on plasma lipid profile including the atherogenic index of plasma (AIP = log [TG/HDL-C]) in patients at high and very high cardiovascular (CV) risk and mixed dyslipi-demia. Method: A total of 81 patients (53 males, 28 females; 60 ± 9.8 years) were included. Mixed dyslipidemia was defined as having 2 of the following 3 lipid abnormalities: LDL-cholesterol (C) >2.5 mmol/l, HDL-C <1.0 mmol/l in males and <1.3 mmol/l in females, triglycerides (TG) >1.7 mmol/l. Global CV risk was estimated according to the current European guidelines. Management with fenofibrate (160-267 mg) + atorvastatin (10-20 mg) or simvastatin (20- 40 mg) was indicated for 6 months. Males and females were stratified according to the AIP risk categories: AIP <0.11 (low risk), AIP >0.21 (high risk). Results: About 3/4 of high or very high CV risk patients with mixed dyslipidemia (n = 81) suffer from impaired glucose metabolism (44% had type 2 diabetes, 30% had impaired fasting glucose). Six-months combined therapy reduced LDL-C (by 29%) and TG (by 40%) signifi-cantly, but the increase of HDL-C (by 3%) was not significant. There were 47% of males and 57% of females who achieved the target LDL-C levels (<25 or <1.8 mmol/l) and 14% of males and 37% of females who received non-HDL-C <2.6 mmol/l at the end of the study. Also AIP was decreased significantly in majority of the patients (high risk AIP decreased from 87% to 47% of males and from 71% to 25% of females). Conclusion: The combined lipid-modifying therapy led to a significant improvement of the plasma lipid profile, particularly of LDL-C, TG, non-HDL-C and AIP. Atherogenic index of plasma seems to be a very useful marker of CV risk in high and very high CV risk patients with mixed dyslipidemia and glucose abnormalities. More intensive management is needed in those patients. ER -
ROSOLOVA, Hana, Milada DOBIASOVA, Vladimír SOŠKA, Vladimir BLAHA, Richard CESKA, Barbora NUSSBAUMEROVA, Terezie PELIKANOVA a Miroslav SOUČEK. Combined therapy of mixed dyslipidemia in patients with high cardiovascular risk and changes in the lipid target values and atherogenic index of plasma. \textit{Cor et Vasa}. Brno: Česká kardiologická společnost, 2014, roč.~56, č.~2, s.~''e133-e139'', 7 s. ISSN~0010-8650. Dostupné z: https://dx.doi.org/10.1016/j.crvasa.2014.01.003.
|