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@article{1186358, author = {Legartová, Soňa and Kozubek, Stanislav and Fránek, Michal and Zdráhal, Zbyněk and Lochmanová, Gabriela and Martinet, Nadine and Bártová, Eva}, article_location = {OTTAWA}, article_number = {2}, doi = {http://dx.doi.org/10.1139/bcb-2013-0082}, keywords = {NEWLY SYNTHESIZED HISTONES; EMBRYONIC STEM-CELLS; NUCLEAR ARRANGEMENT; REPLICATION FORK; H3K9 ACETYLATION; CHROMATIN; TRANSCRIPTION; H4; COMPLEX; SITES}, language = {eng}, issn = {0829-8211}, journal = {BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE}, title = {Cell differentiation along multiple pathways accompanied by changes in histone acetylation status}, url = {http://www.nrcresearchpress.com/doi/abs/10.1139/bcb-2013-0082?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed.VQAanuFFrs4}, volume = {92}, year = {2014} }
TY - JOUR ID - 1186358 AU - Legartová, Soňa - Kozubek, Stanislav - Fránek, Michal - Zdráhal, Zbyněk - Lochmanová, Gabriela - Martinet, Nadine - Bártová, Eva PY - 2014 TI - Cell differentiation along multiple pathways accompanied by changes in histone acetylation status JF - BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE VL - 92 IS - 2 SP - 85-93 EP - 85-93 PB - CANADIAN SCIENCE PUBLISHING SN - 08298211 KW - NEWLY SYNTHESIZED HISTONES KW - EMBRYONIC STEM-CELLS KW - NUCLEAR ARRANGEMENT KW - REPLICATION FORK KW - H3K9 ACETYLATION KW - CHROMATIN KW - TRANSCRIPTION KW - H4 KW - COMPLEX KW - SITES UR - http://www.nrcresearchpress.com/doi/abs/10.1139/bcb-2013-0082?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed.VQAanuFFrs4 L2 - http://www.nrcresearchpress.com/doi/abs/10.1139/bcb-2013-0082?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed.VQAanuFFrs4 N2 - Post-translational modification of histones is fundamental to the regulation of basic nuclear processes and subsequent cellular events, including differentiation. In this study, we analyzed acetylated forms of histones H2A, H2B, and H4 during induced differentiation in mouse (mESCs) and human (hESCs) embryonic stem cells and during induced enterocytic differentiation of colon cancer cells in vitro. Endoderm-like differentiation of mESCs induced by retinoic acid and enterocytic differentiation induced by histone deacetylase inhibitor sodium butyrate were accompanied by increased mono-, di-, and tri-acetylation of histone H2B and a pronounced increase in di- and tri-acetylation of histone H4. In enterocytes, mono- acetylation of histone H2A also increased and tetra-acetylation of histone H4 appeared only after induction of this differentiation pathway. During differentiation of hESCs, we observed increased mono-acetylation and decreased tri-acetylation of H2B. Mono-, di-, and tri-acetylation of H4 were reduced, manifested by a significant increase in nonacetylated H4 histones. Levels of acetylated histones increased during induced differentiation in mESCs and during histone deacetylase (HDAC) inhibitor-induced enterocytic differentiation, whereas differentiation of human ESCs was associated with reduced acetylation of histones H2B and H4. ER -
LEGARTOVÁ, Soňa, Stanislav KOZUBEK, Michal FRÁNEK, Zbyněk ZDRÁHAL, Gabriela LOCHMANOVÁ, Nadine MARTINET a Eva BÁRTOVÁ. Cell differentiation along multiple pathways accompanied by changes in histone acetylation status. \textit{BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE}. OTTAWA: CANADIAN SCIENCE PUBLISHING, 2014, roč.~92, č.~2, s.~85-93. ISSN~0829-8211. Dostupné z: https://dx.doi.org/10.1139/bcb-2013-0082.
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