Tractography of Meyer´s Loop asymmetries

DE GERVAI, Patricia Dreessen, Uta N. SBOTO- FRANKENSTEIN, Bruce R. BOLSTER, Sunny THIND, Marco L.H. GRUWEL, Stephen D. SMITH and Boguslaw TOMANEK. Tractography of Meyer´s Loop asymmetries. Epilepsy Research. Amsterdam: Elsevier Science, 2014, vol. 108, No 5, p. 872-882. ISSN 0920-1211. Available from: https://dx.doi.org/10.1016/j.eplepsyres.2014.03.006.

Basic information

• Original name: Tractography of Meyer´s Loop asymmetries
• Authors: DE GERVAI, Patricia Dreessen (124 Canada), Uta N. SBOTO- FRANKENSTEIN (124 Canada), Bruce R. BOLSTER (124 Canada), Sunny THIND (124 Canada), Marco L.H. GRUWEL (124 Canada), Stephen D. SMITH (124 Canada) and Boguslaw TOMANEK (616 Poland, guarantor, belonging to the institution).
• Edition: Epilepsy Research, Amsterdam, Elsevier Science, 2014, 0920-1211.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30000 3. Medical and Health Sciences
• Country of publisher: Netherlands
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 2.015
• RIV identification code: RIV/00216224:14740/14:00075910
• Organization unit: Central European Institute of Technology
• Doi: http://dx.doi.org/10.1016/j.eplepsyres.2014.03.006
• UT WoS: 000337014800006
• Keywords in English: DIFFUSION TENSOR TRACTOGRAPHY; TEMPORAL-LOBE EPILEPSY; VISUAL-FIELD DEFICITS; OPTIC RADIATION; TRANSSYLVIAN APPROACH; UNCINATE FASCICULUS; FIBER TRACTOGRAPHY; DISSECTION; MRI; VARIABILITY
• Tags: kontrola MP, MP, rivok
• Tags: International impact, Reviewed

Abstract

Purpose: The purpose of the current study was to use diffusion tensor imaging (DTI) to conduct tractography of the optic radiations (OR) and its component bundles and to assess both the degree of hemispheric asymmetry and the inter-subject variability of Meyer's Loop (ML). We hypothesized that there are significant left versus right differences in the anterior extent of ML to the temporal pole (TP) in healthy subjects. Materials and methods: DTI data were acquired on a 3T Siemens MRI system using a single-shot Spin Echo EPI sequence. The dorsal, central and ML bundles of the OR were tracked and visualized in forty hemispheres of twenty healthy volunteers. The uncinate fasciculus (UF) was also tracked in these subjects so that it could be used as a distinct anatomical reference. Measurements were derived for the distance between ML-TP, ML and the temporal horn (ML-TN) and ML and the uncinate fasciculus (ML-UF). Paired difference t-tests were carried out with SPSS 14.0. Results: ML and the UF were successfully tracked and visualized in all 20 volunteers. Significant hemispheric asymmetries were found for all measurements with left distances shorter than the right (P < 0.005). In 50% of the subjects the left ML-UF distance was <= 1.9 mm. Conclusion: The results support our hypothesis and demonstrate that left ML-TP distances are significantly shorter than right ML-TP distances. These asymmetries are also reflected in shorter left distances between ML-TH and ML-UF. Moreover, these results are of interest to left-sided temporal lobe epilepsy surgery because it is not only more likely to disturb the anterior extent of ML but also renders the often closely located posterior aspect of the left UF more vulnerable to potential surgical impact Crown Copyright (C) 2014 Published by Elsevier B.V. All rights reserved.