| SHIH, David J.H., Paul A. NORTHCOTT, Marc REMKE, Andrey KORSHUNOV, Vijay RAMASWAMY, Marcel KOOL, Betty LUU, Yuan YAO, Xin WANG, Adrian M. DUBUC, Livia GARZIA, John PEACOCK, Stephen C. MACK, Xiaochong WU, Adi ROLIDER, Sorana A. MORRISSY, Florence M.G. CAVALLI, David T.W. JONES, Karel ZITTERBART, Claudia C. FARIA, Ulrich SCHULLER, Leoš KŘEN, Toshihiro KUMABE, Teiji TOMINAGA, Young Shin RA, Miklos GARAMI, Peter HAUSER, Jennifer A. CHAN, Shenandoah ROBINSON, László BOGNÁR, Almos KLEKNER, Ali G. SAAD, Linda M. LIAU, Steffen ALBRECHT, Adam FONTEBASSO, Giuseppe CINALLI, Pasqualino De ANTONELLIS, Massimo ZOLLO, Michael K. COOPER, Reid C. THOMPSON, Simon BAILEY, Janet C. LINDSEY, Concezio DI ROCCO, Luca MASSIMI, Erna M.C. MICHIELS, Stephen W. SCHERER, Joanna J. PHILLIPS, Nalin GUPTA, Xing FAN, Karin M. MURASZKO, Rajeev VIBHAKAR, Charles G. EBERHART, Maryam FOULADI, Boleslaw LACH, Shin JUNG, Robert J. WECHSLER-REYA, Michelle FEVRE-MONTANGE, Anne JOUVET, Nada JABADO, Ian F. POLLACK, William A. WEISS, Ji-Yeoun LEE, Byung-Kyu CHO, Seung-Ki KIM, Kyu-Chang WANG, Jeffrey R. LEONARD, Joshua B. RUBIN, Carmen de TORRES, Cinzia LAVARINO, Jaume MORA, Yoon-Jae CHO, Uri TABORI, James M. OLSON, Amar GAJJAR, RogerJ. PACKER, Stefan RUTKOWSKI, Scott L. POMEROY, Pim J. FRENCH, Nanne K. KLOOSTERHOF, Johan M. KROS, Erwin G. VAN MEIR, Steven C. CLIFFORD, Franck BOURDEAUT, Olivier DELATTRE, Francois F. DOZ, Cynthia E. HAWKINS, David MALKIN, Wieslawa A. GRAJKOWSKA, Marta PEREK-POLNIK, Eric BOUFFET, James T. RUTKA, Stefan M. PFISTER and Michael D. TAYLOR. Cytogenetic Prognostication Within Medulloblastoma Subgroups. Journal of clinical oncology. United States: American Society of Clinical Oncology, 2014, vol. 32, No 9, p. 886-896. ISSN 0732-183X. Available from: https://dx.doi.org/10.1200/JCO.2013.50.9539. |
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@article{1194419,
author = {Shih, David J.H. and Northcott, Paul A. and Remke, Marc and Korshunov, Andrey and Ramaswamy, Vijay and Kool, Marcel and Luu, Betty and Yao, Yuan and Wang, Xin and Dubuc, Adrian M. and Garzia, Livia and Peacock, John and Mack, Stephen C. and Wu, Xiaochong and Rolider, Adi and Morrissy, Sorana A. and Cavalli, Florence M.G. and Jones, David T.W. and Zitterbart, Karel and Faria, Claudia C. and Schuller, Ulrich and Křen, Leoš and Kumabe, Toshihiro and Tominaga, Teiji and Ra, Young Shin and Garami, Miklos and Hauser, Peter and Chan, Jennifer A. and Robinson, Shenandoah and Bognár, László and Klekner, Almos and Saad, Ali G. and Liau, Linda M. and Albrecht, Steffen and Fontebasso, Adam and Cinalli, Giuseppe and Antonellis, Pasqualino De and Zollo, Massimo and Cooper, Michael K. and Thompson, Reid C. and Bailey, Simon and Lindsey, Janet C. and Di Rocco, Concezio and Massimi, Luca and Michiels, Erna M.C. and Scherer, Stephen W. and Phillips, Joanna J. and Gupta, Nalin and Fan, Xing and Muraszko, Karin M. and Vibhakar, Rajeev and Eberhart, Charles G. and Fouladi, Maryam and Lach, Boleslaw and Jung, Shin and WechslerandReya, Robert J. and FevreandMontange, Michelle and Jouvet, Anne and Jabado, Nada and Pollack, Ian F. and Weiss, William A. and Lee, JiandYeoun and Cho, ByungandKyu and Kim, SeungandKi and Wang, KyuandChang and Leonard, Jeffrey R. and Rubin, Joshua B. and Torres, Carmen de and Lavarino, Cinzia and Mora, Jaume and Cho, YoonandJae and Tabori, Uri and Olson, James M. and Gajjar, Amar and Packer, RogerJ. and Rutkowski, Stefan and Pomeroy, Scott L. and French, Pim J. and Kloosterhof, Nanne K. and Kros, Johan M. and Van Meir, Erwin G. and Clifford, Steven C. and Bourdeaut, Franck and Delattre, Olivier and Doz, Francois F. and Hawkins, Cynthia E. and Malkin, David and Grajkowska, Wieslawa A. and PerekandPolnik, Marta and Bouffet, Eric and Rutka, James T. and Pfister, Stefan M. and Taylor, Michael D.},
article_location = {United States},
article_number = {9},
doi = {http://dx.doi.org/10.1200/JCO.2013.50.9539},
keywords = {NEUROTROPHIN RECEPTOR TRKC; CHILDHOOD MEDULLOBLASTOMA; BRAIN-TUMORS; MOLECULAR SUBGROUPS; RISK STRATIFICATION; PATHWAY ACTIVATION; OUTCOME PREDICTION; MYCN AMPLIFICATION; TP53 MUTATIONS; POOR-PROGNOSIS},
language = {eng},
issn = {0732-183X},
journal = {Journal of clinical oncology},
title = {Cytogenetic Prognostication Within Medulloblastoma Subgroups},
volume = {32},
year = {2014}
}
TY - JOUR
ID - 1194419
AU - Shih, David J.H. - Northcott, Paul A. - Remke, Marc - Korshunov, Andrey - Ramaswamy, Vijay - Kool, Marcel - Luu, Betty - Yao, Yuan - Wang, Xin - Dubuc, Adrian M. - Garzia, Livia - Peacock, John - Mack, Stephen C. - Wu, Xiaochong - Rolider, Adi - Morrissy, Sorana A. - Cavalli, Florence M.G. - Jones, David T.W. - Zitterbart, Karel - Faria, Claudia C. - Schuller, Ulrich - Křen, Leoš - Kumabe, Toshihiro - Tominaga, Teiji - Ra, Young Shin - Garami, Miklos - Hauser, Peter - Chan, Jennifer A. - Robinson, Shenandoah - Bognár, László - Klekner, Almos - Saad, Ali G. - Liau, Linda M. - Albrecht, Steffen - Fontebasso, Adam - Cinalli, Giuseppe - Antonellis, Pasqualino De - Zollo, Massimo - Cooper, Michael K. - Thompson, Reid C. - Bailey, Simon - Lindsey, Janet C. - Di Rocco, Concezio - Massimi, Luca - Michiels, Erna M.C. - Scherer, Stephen W. - Phillips, Joanna J. - Gupta, Nalin - Fan, Xing - Muraszko, Karin M. - Vibhakar, Rajeev - Eberhart, Charles G. - Fouladi, Maryam - Lach, Boleslaw - Jung, Shin - Wechsler-Reya, Robert J. - Fevre-Montange, Michelle - Jouvet, Anne - Jabado, Nada - Pollack, Ian F. - Weiss, William A. - Lee, Ji-Yeoun - Cho, Byung-Kyu - Kim, Seung-Ki - Wang, Kyu-Chang - Leonard, Jeffrey R. - Rubin, Joshua B. - Torres, Carmen de - Lavarino, Cinzia - Mora, Jaume - Cho, Yoon-Jae - Tabori, Uri - Olson, James M. - Gajjar, Amar - Packer, RogerJ. - Rutkowski, Stefan - Pomeroy, Scott L. - French, Pim J. - Kloosterhof, Nanne K. - Kros, Johan M. - Van Meir, Erwin G. - Clifford, Steven C. - Bourdeaut, Franck - Delattre, Olivier - Doz, Francois F. - Hawkins, Cynthia E. - Malkin, David - Grajkowska, Wieslawa A. - Perek-Polnik, Marta - Bouffet, Eric - Rutka, James T. - Pfister, Stefan M. - Taylor, Michael D.
PY - 2014
TI - Cytogenetic Prognostication Within Medulloblastoma Subgroups
JF - Journal of clinical oncology
VL - 32
IS - 9
SP - 886-896
EP - 886-896
PB - American Society of Clinical Oncology
SN - 0732183X
KW - NEUROTROPHIN RECEPTOR TRKC
KW - CHILDHOOD MEDULLOBLASTOMA
KW - BRAIN-TUMORS
KW - MOLECULAR SUBGROUPS
KW - RISK STRATIFICATION
KW - PATHWAY ACTIVATION
KW - OUTCOME PREDICTION
KW - MYCN AMPLIFICATION
KW - TP53 MUTATIONS
KW - POOR-PROGNOSIS
N2 - Purpose Medulloblastoma comprises four distinct molecular subgroups: WNT, SHH, Group 3, and Group 4. Current medulloblastoma protocols stratify patients based on clinical features: patient age, metastatic stage, extent of resection, and histologic variant. Stark prognostic and genetic differences among the four subgroups suggest that subgroup-specific molecular biomarkers could improve patient prognostication. Patients and Methods Molecular biomarkers were identified from a discovery set of 673 medulloblastomas from 43 cities around the world. Combined risk stratification models were designed based on clinical and cytogenetic biomarkers identified by multivariable Cox proportional hazards analyses. Identified biomarkers were tested using fluorescent in situ hybridization (FISH) on a nonoverlapping medulloblastoma tissue microarray (n = 453), with subsequent validation of the risk stratification models. Results Subgroup information improves the predictive accuracy of a multivariable survival model compared with clinical biomarkers alone. Most previously published cytogenetic biomarkers are only prognostic within a single medulloblastoma subgroup. Profiling six FISH biomarkers (GLI2, MYC, chromosome 11 [chr11], chr14, 17p, and 17q) on formalin-fixed paraffin-embedded tissues, we can reliably and reproducibly identify very low-risk and very high-risk patients within SHH, Group 3, and Group 4 medulloblastomas. Conclusion Combining subgroup and cytogenetic biomarkers with established clinical biomarkers substantially improves patient prognostication, even in the context of heterogeneous clinical therapies. The prognostic significance of most molecular biomarkers is restricted to a specific subgroup. We have identified a small panel of cytogenetic biomarkers that reliably identifies very high-risk and very low-risk groups of patients, making it an excellent tool for selecting patients for therapy intensification and therapy de-escalation in future clinical trials.
ER -
SHIH, David J.H., Paul A. NORTHCOTT, Marc REMKE, Andrey KORSHUNOV, Vijay RAMASWAMY, Marcel KOOL, Betty LUU, Yuan YAO, Xin WANG, Adrian M. DUBUC, Livia GARZIA, John PEACOCK, Stephen C. MACK, Xiaochong WU, Adi ROLIDER, Sorana A. MORRISSY, Florence M.G. CAVALLI, David T.W. JONES, Karel ZITTERBART, Claudia C. FARIA, Ulrich SCHULLER, Leoš KŘEN, Toshihiro KUMABE, Teiji TOMINAGA, Young Shin RA, Miklos GARAMI, Peter HAUSER, Jennifer A. CHAN, Shenandoah ROBINSON, László BOGNÁR, Almos KLEKNER, Ali G. SAAD, Linda M. LIAU, Steffen ALBRECHT, Adam FONTEBASSO, Giuseppe CINALLI, Pasqualino De ANTONELLIS, Massimo ZOLLO, Michael K. COOPER, Reid C. THOMPSON, Simon BAILEY, Janet C. LINDSEY, Concezio DI ROCCO, Luca MASSIMI, Erna M.C. MICHIELS, Stephen W. SCHERER, Joanna J. PHILLIPS, Nalin GUPTA, Xing FAN, Karin M. MURASZKO, Rajeev VIBHAKAR, Charles G. EBERHART, Maryam FOULADI, Boleslaw LACH, Shin JUNG, Robert J. WECHSLER-REYA, Michelle FEVRE-MONTANGE, Anne JOUVET, Nada JABADO, Ian F. POLLACK, William A. WEISS, Ji-Yeoun LEE, Byung-Kyu CHO, Seung-Ki KIM, Kyu-Chang WANG, Jeffrey R. LEONARD, Joshua B. RUBIN, Carmen de TORRES, Cinzia LAVARINO, Jaume MORA, Yoon-Jae CHO, Uri TABORI, James M. OLSON, Amar GAJJAR, RogerJ. PACKER, Stefan RUTKOWSKI, Scott L. POMEROY, Pim J. FRENCH, Nanne K. KLOOSTERHOF, Johan M. KROS, Erwin G. VAN MEIR, Steven C. CLIFFORD, Franck BOURDEAUT, Olivier DELATTRE, Francois F. DOZ, Cynthia E. HAWKINS, David MALKIN, Wieslawa A. GRAJKOWSKA, Marta PEREK-POLNIK, Eric BOUFFET, James T. RUTKA, Stefan M. PFISTER and Michael D. TAYLOR. Cytogenetic Prognostication Within Medulloblastoma Subgroups. \textit{Journal of clinical oncology}. United States: American Society of Clinical Oncology, 2014, vol.~32, No~9, p.~886-896. ISSN~0732-183X. Available from: https://dx.doi.org/10.1200/JCO.2013.50.9539.
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