Functional divergence and population replacement in British bank voles

KOTLÍK, Petr, Silvia MARKOVÁ, Libor VOJTEK, Mateusz KONCZAL, Pavel HYRŠL a Jeremy SAERLE. Functional divergence and population replacement in British bank voles. In 14th Rodens et Spatium. 2014.

Základní údaje

Originální název

Functional divergence and population replacement in British bank voles

Název česky

Functional divergence and population replacement in British bank voles

Autoři

KOTLÍK, Petr (203 Česká republika, garant), Silvia MARKOVÁ (203 Česká republika), Libor VOJTEK (203 Česká republika, domácí), Mateusz KONCZAL (616 Polsko), Pavel HYRŠL (203 Česká republika) a Jeremy SAERLE (826 Velká Británie a Severní Irsko)

Vydání

14th Rodens et Spatium, 2014

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Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

30105 Physiology

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14310/14:00076162

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova česky

bank vole; haemoglobin; Clethrionomys glareolus; oxidative stress; colonization

Klíčová slova anglicky

bank vole; haemoglobin; Clethrionomys glareolus; oxidative stress; colonization

Příznaky

Mezinárodní význam, Recenzováno

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Anotace

V originále

We describe the functional consequences of haemoglobin divergence between two British populations of the bank vole (Clethrionomys$glareolus), one that partially replaced the other during endVglacial colonization from mainland, to examine the possibility of adaptive processes in explaining the replacement. We determine the amino acid substitution of serine for cysteine in the beta haemoglobin chain as the mutation underlying the divergence between the two populations. We demonstrate that this mutation increases the tolerance of bank vole blood cells to oxidative stress. Because levels of oxidative stress correlate with a variety of physiological and pathological states, we argue that the mutation may have conveyed a competitive advantage over the first colonists, promoting the replacement. Our study thus provides striking evidence for physiological differences between populations that spread at the expense of one another during colonization of an area from different glacial refugia, and suggests that selection may have had an important role in endVglacial colonization history and, thus, in establishing the current distributions of species.

Česky

We describe the functional consequences of haemoglobin divergence between two British populations of the bank vole (Clethrionomys$glareolus), one that partially replaced the other during endVglacial colonization from mainland, to examine the possibility of adaptive processes in explaining the replacement. We determine the amino acid substitution of serine for cysteine in the beta haemoglobin chain as the mutation underlying the divergence between the two populations. We demonstrate that this mutation increases the tolerance of bank vole blood cells to oxidative stress. Because levels of oxidative stress correlate with a variety of physiological and pathological states, we argue that the mutation may have conveyed a competitive advantage over the first colonists, promoting the replacement. Our study thus provides striking evidence for physiological differences between populations that spread at the expense of one another during colonization of an area from different glacial refugia, and suggests that selection may have had an important role in endVglacial colonization history and, thus, in establishing the current distributions of species.