A Single or Split Dose Picosulphate/Magnesium Citrate Before
Colonoscopy: Comparison Regarding Tolerance and Efficacy with
Polyethylene Glycol. A Randomized Trial

J 2014

A Single or Split Dose Picosulphate/Magnesium Citrate Before Colonoscopy: Comparison Regarding Tolerance and Efficacy with Polyethylene Glycol. A Randomized Trial

KOJECKY, Vladimir, Jiří DOLINA, Bohuslav KIANIČKA, Miroslav MISUREC, Michal VARGA et. al.

Základní údaje

Originální název

A Single or Split Dose Picosulphate/Magnesium Citrate Before Colonoscopy: Comparison Regarding Tolerance and Efficacy with Polyethylene Glycol. A Randomized Trial

Autoři

KOJECKY, Vladimir (203 Česká republika), Jiří DOLINA (203 Česká republika, garant, domácí), Bohuslav KIANIČKA (203 Česká republika, domácí), Miroslav MISUREC (203 Česká republika), Michal VARGA (203 Česká republika), Jiri LATTA (203 Česká republika) a Vladimir VACULIN (203 Česká republika)

Vydání

Journal of Gastrointestinal and Liver Diseases, CLUJ-NAPOCA, MEDICAL UNIV PRESS, 2014, 1841-8724

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Rumunsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.202

Kód RIV

RIV/00216224:14110/14:00076236

Organizační jednotka

Lékařská fakulta

UT WoS

000337333300007

Klíčová slova anglicky

colonoscopy; bowel preparation; sodium picosulphate; polyethylene glycol

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 28. 8. 2014 14:11, Soňa Böhmová

Anotace

V originále

To compare the efficacy and tolerance of sodium picosulphate/magnesium citrate (PMC) and polyethylene glycol (PEG) in a single or split dose regimen for colonoscopy bowel preparation. Methods: A prospective, randomized, endoscopist-blinded, multicenter study. The patients were randomly assigned to receive PMC (PMC4/0) or PEG (PEG4/0) in a single dose 4L day before colonoscopy or a split dose 2+2L PMC (PMC2/2) or 3+1L PEG (PEG3/1) one day before and in the morning before the colonoscopy. Each patient was interviewed to determine his/her subjective tolerance of the preparation before the procedure. The quality of bowel cleansing was assessed in a blinded test performed by multiple endoscopists using the Aronchick scale. Results: A total of 600 patients were enrolled, 88.2% were included in the analysis. Satisfactory bowel cleansing (Aronchick score 1 and 2) was significantly more frequent when a split dose was used irrespective of the solution type (81.6% PMC2/2, 87.3% PEG3/1 vs. 73.0% PEG4/0, p = 0.024). In single dose regimens, PMC performed better than PEG (82.6% vs. 73.0%). Single or split dose PMC preparations were comparable. A PMC based solution was generally better tolerated than PEG regardless of the regimen used (p <0.001). Nausea was reported mostly after the 4L PEG (32.8%, p < 0.001), incontinence after a split PMC dose (34.4%, p = 0.002), and bloating after the 4L PEG (38.0%, p < 0.001). There was no significant difference in the prevalence of vomiting. Conclusion: Colonic preparation with PMC yields similar results as a split PEG dose, regardless of whether PMC is administered in single or separate doses. PMC is better tolerated than any PEG-based preparation. A single 4L PEG the day before the colonoscopy is less appropriate for bowel cleansing.

Citovat

KOJECKY, Vladimir, Jiří DOLINA, Bohuslav KIANIČKA, Miroslav MISUREC, Michal VARGA, Jiri LATTA a Vladimir VACULIN. A Single or Split Dose Picosulphate/Magnesium Citrate Before Colonoscopy: Comparison Regarding Tolerance and Efficacy with Polyethylene Glycol. A Randomized Trial. Journal of Gastrointestinal and Liver Diseases. CLUJ-NAPOCA: MEDICAL UNIV PRESS, 2014, roč. 23, č. 2, s. 141-146. ISSN 1841-8724.

@article{1195779,
   author = {Kojecky, Vladimir and Dolina, Jiří and Kianička, Bohuslav and Misurec, Miroslav and Varga, Michal and Latta, Jiri and Vaculin, Vladimir},
   article_location = {CLUJ-NAPOCA},
   article_number = {2},
   keywords = {colonoscopy; bowel preparation; sodium picosulphate; polyethylene glycol},
   language = {eng},
   issn = {1841-8724},
   journal = {Journal of Gastrointestinal and Liver Diseases},
   title = {A Single or Split Dose Picosulphate/Magnesium Citrate Before Colonoscopy: Comparison Regarding Tolerance and Efficacy with Polyethylene Glycol. A Randomized Trial},
   volume = {23},
   year = {2014}
}

TY  - JOUR
ID  - 1195779
AU  - Kojecky, Vladimir - Dolina, Jiří - Kianička, Bohuslav - Misurec, Miroslav - Varga, Michal - Latta, Jiri - Vaculin, Vladimir
PY  - 2014
TI  - A Single or Split Dose Picosulphate/Magnesium Citrate Before Colonoscopy: Comparison Regarding Tolerance and Efficacy with Polyethylene Glycol. A Randomized Trial
JF  - Journal of Gastrointestinal and Liver Diseases
VL  - 23
IS  - 2
SP  - 141-146
EP  - 141-146
PB  - MEDICAL UNIV PRESS
SN  - 18418724
KW  - colonoscopy
KW  - bowel preparation
KW  - sodium picosulphate
KW  - polyethylene glycol
N2  - To compare the efficacy and tolerance of sodium picosulphate/magnesium citrate (PMC) and polyethylene glycol (PEG) in a single or split dose regimen for colonoscopy bowel preparation. Methods: A prospective, randomized, endoscopist-blinded, multicenter study. The patients were randomly assigned to receive PMC (PMC4/0) or PEG (PEG4/0) in a single dose 4L day before colonoscopy or a split dose 2+2L PMC (PMC2/2) or 3+1L PEG (PEG3/1) one day before and in the morning before the colonoscopy. Each patient was interviewed to determine his/her subjective tolerance of the preparation before the procedure. The quality of bowel cleansing was assessed in a blinded test performed by multiple endoscopists using the Aronchick scale. Results: A total of 600 patients were enrolled, 88.2% were included in the analysis. Satisfactory bowel cleansing (Aronchick score 1 and 2) was significantly more frequent when a split dose was used irrespective of the solution type (81.6% PMC2/2, 87.3% PEG3/1 vs. 73.0% PEG4/0, p = 0.024). In single dose regimens, PMC performed better than PEG (82.6% vs. 73.0%). Single or split dose PMC preparations were comparable. A PMC based solution was generally better tolerated than PEG regardless of the regimen used (p <0.001). Nausea was reported mostly after the 4L PEG (32.8%, p < 0.001), incontinence after a split PMC dose (34.4%, p = 0.002), and bloating after the 4L PEG (38.0%, p < 0.001). There was no significant difference in the prevalence of vomiting. Conclusion: Colonic preparation with PMC yields similar results as a split PEG dose, regardless of whether PMC is administered in single or separate doses. PMC is better tolerated than any PEG-based preparation. A single 4L PEG the day before the colonoscopy is less appropriate for bowel cleansing.
ER  -

KOJECKY, Vladimir, Jiří DOLINA, Bohuslav KIANIČKA, Miroslav MISUREC, Michal VARGA, Jiri LATTA a Vladimir VACULIN. A Single or Split Dose Picosulphate/Magnesium Citrate Before Colonoscopy: Comparison Regarding Tolerance and Efficacy with Polyethylene Glycol. A Randomized Trial. \textit{Journal of Gastrointestinal and Liver Diseases}. CLUJ-NAPOCA: MEDICAL UNIV PRESS, 2014, roč.~23, č.~2, s.~141-146. ISSN~1841-8724.

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