Non-invasive brain stimulation of the right inferior frontal
gyrus may improve attention in early Alzheimer’s disease: A
pilot study

J 2014

Non-invasive brain stimulation of the right inferior frontal gyrus may improve attention in early Alzheimer’s disease: A pilot study

ELIÁŠOVÁ, Ilona, Ľubomíra ANDERKOVÁ, Radek MAREČEK a Irena REKTOROVÁ

Základní údaje

Originální název

Non-invasive brain stimulation of the right inferior frontal gyrus may improve attention in early Alzheimer’s disease: A pilot study

Autoři

ELIÁŠOVÁ, Ilona (203 Česká republika, domácí), Ľubomíra ANDERKOVÁ (703 Slovensko, domácí), Radek MAREČEK (203 Česká republika, domácí) a Irena REKTOROVÁ (203 Česká republika, garant, domácí)

Vydání

Journal of the neurological sciences, Netherlands, Amsterdam : Elsevier, 2014, 0022-510X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.474

Kód RIV

RIV/00216224:14740/14:00076257

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1016/j.jns.2014.08.036

UT WoS

000345947400055

Klíčová slova anglicky

rTMS; noninvasive brain stimulation; inferior frontal gyrus; MCI; Alzheimer’s disease; attention; cognitive speed; executive function

Štítky

kontrola MP, rivok, SCOPUS

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 13. 3. 2018 13:27, Mgr. et Mgr. Ľubomíra Nováková, Ph.D.

Anotace

V originále

Introduction Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive tool for modulating cortical activity. Objectives In this pilot study, we evaluated the effects of high frequency rTMS applied over the right inferior frontal gyrus (IFG) on cognitive functions in patients with amnestic mild cognitive impairment (MCI) or incipient dementia due to Alzheimer’s disease (AD). Methods Ten patients (6 men; 4 women, mean age 72 ± 8 years; MMSE 23 ± 3.56) were enrolled in a randomized, placebo-controlled study with a crossover design. All participants received 2 sessions of 10 Hz rTMS over the non-dominant right hemisphere in random order: IFG (active stimulation site) and vertex (control stimulation site). Intensities were adjusted to 90% of resting motor threshold. A total of 2250 pulses were applied in a session. The Trail Making Test (TMT), the Stroop test, and the complex visual scene encoding task (CVSET) were administered before and immediately after each session. The Wilcoxon paired test was used for data analysis. Results Stimulation applied over the IFG induced improvement in the TMT parts A (p = 0.037) and B (p = 0.049). No significant changes were found in the Stroop test or the CVSET after the IFG stimulation. We observed no significant cognitive aftereffects of rTMS applied over the vertex. Conclusions High frequency rTMS of the right IFG induced significant improvement of attention and psychomotor speed in patients with MCI/mild dementia due to AD. This pilot study is part of a more complex protocol and ongoing research.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

Citovat

ELIÁŠOVÁ, Ilona, Ľubomíra ANDERKOVÁ, Radek MAREČEK a Irena REKTOROVÁ. Non-invasive brain stimulation of the right inferior frontal gyrus may improve attention in early Alzheimer’s disease: A pilot study. Journal of the neurological sciences. Netherlands: Amsterdam : Elsevier, 2014, roč. 346, 1-2, s. 318-322. ISSN 0022-510X. Dostupné z: https://dx.doi.org/10.1016/j.jns.2014.08.036.

@article{1195853,
   author = {Eliášová, Ilona and Anderková, Ľubomíra and Mareček, Radek and Rektorová, Irena},
   article_location = {Netherlands},
   article_number = {1-2},
   doi = {http://dx.doi.org/10.1016/j.jns.2014.08.036},
   keywords = {rTMS; noninvasive brain stimulation; inferior frontal gyrus; MCI; Alzheimer’s disease; attention; cognitive speed; executive function},
   language = {eng},
   issn = {0022-510X},
   journal = {Journal of the neurological sciences},
   title = {Non-invasive brain stimulation of the right inferior frontal gyrus may improve attention in early Alzheimer’s disease: A pilot study},
   url = {http://www.sciencedirect.com/science/article/pii/S0022510X14005681#},
   volume = {346},
   year = {2014}
}

TY  - JOUR
ID  - 1195853
AU  - Eliášová, Ilona - Anderková, Ľubomíra - Mareček, Radek - Rektorová, Irena
PY  - 2014
TI  - Non-invasive brain stimulation of the right inferior frontal gyrus may improve attention in early Alzheimer’s disease: A pilot study
JF  - Journal of the neurological sciences
VL  - 346
IS  - 1-2
SP  - 318-322
EP  - 318-322
PB  - Amsterdam : Elsevier
SN  - 0022510X
KW  - rTMS
KW  - noninvasive brain stimulation
KW  - inferior frontal gyrus
KW  - MCI
KW  - Alzheimer’s disease
KW  - attention
KW  - cognitive speed
KW  - executive function
UR  - http://www.sciencedirect.com/science/article/pii/S0022510X14005681#
L2  - http://www.sciencedirect.com/science/article/pii/S0022510X14005681#
N2  - Introduction Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive tool for modulating cortical activity. Objectives In this pilot study, we evaluated the effects of high frequency rTMS applied over the right inferior frontal gyrus (IFG) on cognitive functions in patients with amnestic mild cognitive impairment (MCI) or incipient dementia due to Alzheimer’s disease (AD). Methods Ten patients (6 men; 4 women, mean age 72 ± 8 years; MMSE 23 ± 3.56) were enrolled in a randomized, placebo-controlled study with a crossover design. All participants received 2 sessions of 10 Hz rTMS over the non-dominant right hemisphere in random order: IFG (active stimulation site) and vertex (control stimulation site). Intensities were adjusted to 90% of resting motor threshold. A total of 2250 pulses were applied in a session. The Trail Making Test (TMT), the Stroop test, and the complex visual scene encoding task (CVSET) were administered before and immediately after each session. The Wilcoxon paired test was used for data analysis. Results Stimulation applied over the IFG induced improvement in the TMT parts A (p = 0.037) and B (p = 0.049). No significant changes were found in the Stroop test or the CVSET after the IFG stimulation. We observed no significant cognitive aftereffects of rTMS applied over the vertex. Conclusions High frequency rTMS of the right IFG induced significant improvement of attention and psychomotor speed in patients with MCI/mild dementia due to AD. This pilot study is part of a more complex protocol and ongoing research.
ER  -

ELIÁŠOVÁ, Ilona, Ľubomíra ANDERKOVÁ, Radek MAREČEK a Irena REKTOROVÁ. Non-invasive brain stimulation of the right inferior frontal gyrus may improve attention in early Alzheimer’s disease: A pilot study. \textit{Journal of the neurological sciences}. Netherlands: Amsterdam : Elsevier, 2014, roč.~346, 1-2, s.~318-322. ISSN~0022-510X. Dostupné z: https://dx.doi.org/10.1016/j.jns.2014.08.036.

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