a 2014

Analyzing the defense strategies of Staphylococcus aureus strains against polyvalent bacteriophages

VARGA, Marian, Monika ZOUHAROVÁ, Roman PANTŮČEK, Marek MOŠA, Jiří DOŠKAŘ et. al.

Basic information

Original name

Analyzing the defense strategies of Staphylococcus aureus strains against polyvalent bacteriophages

Authors

VARGA, Marian, Monika ZOUHAROVÁ, Roman PANTŮČEK, Marek MOŠA and Jiří DOŠKAŘ

Edition

International Symposium on Staphylococci & Staphylococcal Infections - ISSSI 2014, Chicago, IL, USA, 2014

Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

Genetics and molecular biology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Organization unit

Faculty of Science

Tags

International impact
Změněno: 18/3/2016 13:00, Mgr. et Mgr. Veronika Oškerová, Ph.D.

Abstract

V originále

The emergence and alarming increase of multiresistant strains of Staphylococcus aureus emphasizes the need for new and inovative antimicrobial strategies. One of them is phage therapy that represents a promising alternative to the use of antibiotics for combating bacterial infections. Some strains, however, are resistant to therapeutic bacteriophages, which may decrease the effectivity of phage-based drugs. In our study, we analyzed causes responsible for this resistance, mainly: (i) efficacy of phage adsorption to bacterial cells; (ii) interference with the products of the prophage-borne genes in lysogenic strains; and (iii) effect of CRISPR-Cas elements.

Links

EE2.3.20.0183, research and development project
Name: Centrum experimentální biomedicíny
EE2.4.31.0155, research and development project
Name: Partnerství a sítě pro spolupráci v experimentální biologii
TA01010405, research and development project
Name: Výzkum stafylokokových bakteriofágových mutant s širokým spektrem hostitelů (Acronym: TAČR/IMUNA-1)
Investor: Technology Agency of the Czech Republic