Period3 VNTR polymorphism influences the time-of-day pain onset
of acute myocardial infarction with ST elevation

J 2014

Period3 VNTR polymorphism influences the time-of-day pain onset of acute myocardial infarction with ST elevation

LIPKOVÁ, Jolana, Zbyněk ŠPLÍCHAL, Julie BIENERTOVÁ VAŠKŮ, Michal JURAJDA, Jiří PAŘENICA et. al.

Základní údaje

Originální název

Period3 VNTR polymorphism influences the time-of-day pain onset of acute myocardial infarction with ST elevation

Název česky

Vliv Period3 VNTR polymorfismu na dobu začátku potíží akutního infarktu myokardu s ST elevacemi

Autoři

LIPKOVÁ, Jolana (203 Česká republika, domácí), Zbyněk ŠPLÍCHAL (203 Česká republika, domácí), Julie BIENERTOVÁ VAŠKŮ (203 Česká republika, domácí), Michal JURAJDA (203 Česká republika, domácí), Jiří PAŘENICA (203 Česká republika, domácí), Anna VAŠKŮ (203 Česká republika, domácí) a Monika PÁVKOVÁ GOLDBERGOVÁ (203 Česká republika, garant, domácí)

Vydání

Chronobiology International, London, Informa Healthcare, 2014, 0742-0528

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30105 Physiology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.343

Kód RIV

RIV/00216224:14110/14:00076387

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.3109/07420528.2014.921790

UT WoS

000341754000002

Klíčová slova česky

cirkadiánní hodiny; Per3 VNTR polymorphism; cosinor analýza; srdeční selhání; infarkt myokardu

Klíčová slova anglicky

Circadian clock; Per3 VNTR polymorphism; cosinor analysis; heart failure; myocardial infarction

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 17. 3. 2015 17:26, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

It is well established that the incidence and infarct size in acute myocardial infarction (AMI) is subject to circadian variations. At the molecular level, circadian clocks in distinct cells, including cardiomyocytes, generate 24-h cycles of biochemical processes. Possible imbalance or impairment in the cell clock mechanism may alter the cardiac metabolism and function and increase the susceptibility of cardiovascular diseases. One of the key components of the human clock system PERIOD3 (PER3) has been recently demonstrated to affect circadian expression of various genes in different tissues, including the heart. The variable number tandem repeat (VNTR) polymorphism (rs57875989) in gene Period3 (Per3) is related to multiple phenotypic parameters, including diurnal preference, sleep homeostasis, infection and cancer. The aim of our study was to investigate the effect of this polymorphism in AMI with ST elevation (STEMI). The study subjects (314 patients of Caucasian origin with STEMI, and 332 healthy controls) were genotyped for Per3 VNTR polymorphism using an allele-specific polymerase chain reaction. A gender difference in circadian rhythmicity of pain onset was observed with significant circadian pattern in men. Furthermore, the Per3(5/5) variant carriers were associated with higher levels of interleukin-6, B-type natriuretic peptide and lower vitamin A levels. By using cosinor analysis we observed different circadian distribution patterns of AMI onset at the level of genotype and allelic frequencies. Genotypes with at least one 4-repeat allele (Per3(4/5) and Per3(4/4)) (N = 264) showed remarkable circadian activity in comparison with Per3(5/5) (N = 50), especially in men. No significant differences in genotype and/or allele frequencies of Per3 VNTR polymorphism were observed when comparing STEMI cases and controls. Our results indicate that the Per3 VNTR may contribute to modulation of cardiac functions and interindividual differences in development and progression of myocardial infarction.

Návaznosti

MUNI/A/1003/2013, interní kód MU

Název: Molekulární patofyziologie vybraných komplexních nemocí

Investor: Masarykova univerzita, Molekulární patofyziologie vybraných komplexních nemocí, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

LIPKOVÁ, Jolana, Zbyněk ŠPLÍCHAL, Julie BIENERTOVÁ VAŠKŮ, Michal JURAJDA, Jiří PAŘENICA, Anna VAŠKŮ a Monika PÁVKOVÁ GOLDBERGOVÁ. Period3 VNTR polymorphism influences the time-of-day pain onset of acute myocardial infarction with ST elevation. Chronobiology International. London: Informa Healthcare, 2014, roč. 31, č. 8, s. 878-890. ISSN 0742-0528. Dostupné z: https://dx.doi.org/10.3109/07420528.2014.921790.

@article{1197185,
   author = {Lipková, Jolana and Šplíchal, Zbyněk and Bienertová Vašků, Julie and Jurajda, Michal and Pařenica, Jiří and Vašků, Anna and Pávková Goldbergová, Monika},
   article_location = {London},
   article_number = {8},
   doi = {http://dx.doi.org/10.3109/07420528.2014.921790},
   keywords = {Circadian clock; Per3 VNTR polymorphism; cosinor analysis; heart failure; myocardial infarction},
   language = {eng},
   issn = {0742-0528},
   journal = {Chronobiology International},
   title = {Period3 VNTR polymorphism influences the time-of-day pain onset of acute myocardial infarction with ST elevation},
   volume = {31},
   year = {2014}
}

TY  - JOUR
ID  - 1197185
AU  - Lipková, Jolana - Šplíchal, Zbyněk - Bienertová Vašků, Julie - Jurajda, Michal - Pařenica, Jiří - Vašků, Anna - Pávková Goldbergová, Monika
PY  - 2014
TI  - Period3 VNTR polymorphism influences the time-of-day pain onset of acute myocardial infarction with ST elevation
JF  - Chronobiology International
VL  - 31
IS  - 8
SP  - 878-890
EP  - 878-890
PB  - Informa Healthcare
SN  - 07420528
KW  - Circadian clock
KW  - Per3 VNTR polymorphism
KW  - cosinor analysis
KW  - heart failure
KW  - myocardial infarction
N2  - It is well established that the incidence and infarct size in acute myocardial infarction (AMI) is subject to circadian variations. At the molecular level, circadian clocks in distinct cells, including cardiomyocytes, generate 24-h cycles of biochemical processes. Possible imbalance or impairment in the cell clock mechanism may alter the cardiac metabolism and function and increase the susceptibility of cardiovascular diseases. One of the key components of the human clock system PERIOD3 (PER3) has been recently demonstrated to affect circadian expression of various genes in different tissues, including the heart. The variable number tandem repeat (VNTR) polymorphism (rs57875989) in gene Period3 (Per3) is related to multiple phenotypic parameters, including diurnal preference, sleep homeostasis, infection and cancer. The aim of our study was to investigate the effect of this polymorphism in AMI with ST elevation (STEMI). The study subjects (314 patients of Caucasian origin with STEMI, and 332 healthy controls) were genotyped for Per3 VNTR polymorphism using an allele-specific polymerase chain reaction. A gender difference in circadian rhythmicity of pain onset was observed with significant circadian pattern in men. Furthermore, the Per3(5/5) variant carriers were associated with higher levels of interleukin-6, B-type natriuretic peptide and lower vitamin A levels. By using cosinor analysis we observed different circadian distribution patterns of AMI onset at the level of genotype and allelic frequencies. Genotypes with at least one 4-repeat allele (Per3(4/5) and Per3(4/4)) (N = 264) showed remarkable circadian activity in comparison with Per3(5/5) (N = 50), especially in men. No significant differences in genotype and/or allele frequencies of Per3 VNTR polymorphism were observed when comparing STEMI cases and controls. Our results indicate that the Per3 VNTR may contribute to modulation of cardiac functions and interindividual differences in development and progression of myocardial infarction.
ER  -

LIPKOVÁ, Jolana, Zbyněk ŠPLÍCHAL, Julie BIENERTOVÁ VAŠKŮ, Michal JURAJDA, Jiří PAŘENICA, Anna VAŠKŮ a Monika PÁVKOVÁ GOLDBERGOVÁ. Period3 VNTR polymorphism influences the time-of-day pain onset of acute myocardial infarction with ST elevation. \textit{Chronobiology International}. London: Informa Healthcare, 2014, roč.~31, č.~8, s.~878-890. ISSN~0742-0528. Dostupné z: https://dx.doi.org/10.3109/07420528.2014.921790.

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