Functional Imaging of the Cerebellum and Basal Ganglia During
Predictive Motor Timing in Early Parkinson's Disease

J 2014

Functional Imaging of the Cerebellum and Basal Ganglia During Predictive Motor Timing in Early Parkinson's Disease

ČECHOVÁ, Ivica, Ovidiu V LUNGU, Radek MAREČEK, Michal MIKL, Tomáš GESCHEIDT et. al.

Základní údaje

Originální název

Functional Imaging of the Cerebellum and Basal Ganglia During Predictive Motor Timing in Early Parkinson's Disease

Autoři

ČECHOVÁ, Ivica (703 Slovensko, domácí), Ovidiu V LUNGU (124 Kanada), Radek MAREČEK (203 Česká republika, domácí), Michal MIKL (203 Česká republika, domácí), Tomáš GESCHEIDT (203 Česká republika), Petr KRUPA (203 Česká republika) a Martin BAREŠ (203 Česká republika, garant, domácí)

Vydání

Journal of Neuroimaging, Hoboken, USA, WILEY-BLACKWELL, 2014, 1051-2284

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.734

Kód RIV

RIV/00216224:14110/14:00076462

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1111/j.1552-6569.2011.00663.x

UT WoS

000329509100008

Klíčová slova anglicky

Basal ganglia; cerebellum; fMRI; Parkinson's disease; prediction; timing

Štítky

EL OK, podil

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 16. 9. 2014 12:54, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

BACKGROUND AND PURPOSEThe basal ganglia and the cerebellum have both emerged as important structures involved in the processing of temporal information. METHODSWe examined the roles of the cerebellum and striatum in predictive motor timing during a target interception task in healthy individuals (HC group; n = 21) and in patients with early Parkinson's disease (early stage PD group; n = 20) using functional magnetic resonance imaging. RESULTSDespite having similar hit ratios, the PD failed more often than the HC to postpone their actions until the right moment and to adapt their behavior from one trial to the next. We found more activation in the right cerebellar lobule VI in HC than in early stage PD during successful trials. Successful trial-by-trial adjustments were associated with higher activity in the right putamen and lobule VI of the cerebellum in HC. CONCLUSIONSWe conclude that both the cerebellum and striatum are involved in predictive motor timing tasks. The cerebellar activity is associated exclusively with the postponement of action until the right moment, whereas both the cerebellum and striatum are needed for successful adaptation of motor actions from one trial to the next. We found a general hypoactivation'' of basal ganglia and cerebellum in early stage PD relative to HC, indicating that even in early stages of the PD there could be functional perturbations in the motor system beyond striatum.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

MSM0021622404, záměr

Název: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Přiložené soubory

EL_Functional_imaging.pdf

Požádat o autorskou verzi souboru

Citovat

ČECHOVÁ, Ivica, Ovidiu V LUNGU, Radek MAREČEK, Michal MIKL, Tomáš GESCHEIDT, Petr KRUPA a Martin BAREŠ. Functional Imaging of the Cerebellum and Basal Ganglia During Predictive Motor Timing in Early Parkinson's Disease. Journal of Neuroimaging. Hoboken, USA: WILEY-BLACKWELL, 2014, roč. 24, č. 1, s. 45-53. ISSN 1051-2284. Dostupné z: https://dx.doi.org/10.1111/j.1552-6569.2011.00663.x.

@article{1197981,
   author = {Čechová, Ivica and Lungu, Ovidiu V and Mareček, Radek and Mikl, Michal and Gescheidt, Tomáš and Krupa, Petr and Bareš, Martin},
   article_location = {Hoboken, USA},
   article_number = {1},
   doi = {http://dx.doi.org/10.1111/j.1552-6569.2011.00663.x},
   keywords = {Basal ganglia; cerebellum; fMRI; Parkinson's disease; prediction; timing},
   language = {eng},
   issn = {1051-2284},
   journal = {Journal of Neuroimaging},
   title = {Functional Imaging of the Cerebellum and Basal Ganglia During Predictive Motor Timing in Early Parkinson's Disease},
   volume = {24},
   year = {2014}
}

TY  - JOUR
ID  - 1197981
AU  - Čechová, Ivica - Lungu, Ovidiu V - Mareček, Radek - Mikl, Michal - Gescheidt, Tomáš - Krupa, Petr - Bareš, Martin
PY  - 2014
TI  - Functional Imaging of the Cerebellum and Basal Ganglia During Predictive Motor Timing in Early Parkinson's Disease
JF  - Journal of Neuroimaging
VL  - 24
IS  - 1
SP  - 45-53
EP  - 45-53
PB  - WILEY-BLACKWELL
SN  - 10512284
KW  - Basal ganglia
KW  - cerebellum
KW  - fMRI
KW  - Parkinson's disease
KW  - prediction
KW  - timing
N2  - BACKGROUND AND PURPOSEThe basal ganglia and the cerebellum have both emerged as important structures involved in the processing of temporal information. METHODSWe examined the roles of the cerebellum and striatum in predictive motor timing during a target interception task in healthy individuals (HC group; n = 21) and in patients with early Parkinson's disease (early stage PD group; n = 20) using functional magnetic resonance imaging. RESULTSDespite having similar hit ratios, the PD failed more often than the HC to postpone their actions until the right moment and to adapt their behavior from one trial to the next. We found more activation in the right cerebellar lobule VI in HC than in early stage PD during successful trials. Successful trial-by-trial adjustments were associated with higher activity in the right putamen and lobule VI of the cerebellum in HC. CONCLUSIONSWe conclude that both the cerebellum and striatum are involved in predictive motor timing tasks. The cerebellar activity is associated exclusively with the postponement of action until the right moment, whereas both the cerebellum and striatum are needed for successful adaptation of motor actions from one trial to the next. We found a general hypoactivation'' of basal ganglia and cerebellum in early stage PD relative to HC, indicating that even in early stages of the PD there could be functional perturbations in the motor system beyond striatum.
ER  -

ČECHOVÁ, Ivica, Ovidiu V LUNGU, Radek MAREČEK, Michal MIKL, Tomáš GESCHEIDT, Petr KRUPA a Martin BAREŠ. Functional Imaging of the Cerebellum and Basal Ganglia During Predictive Motor Timing in Early Parkinson's Disease. \textit{Journal of Neuroimaging}. Hoboken, USA: WILEY-BLACKWELL, 2014, roč.~24, č.~1, s.~45-53. ISSN~1051-2284. Dostupné z: https://dx.doi.org/10.1111/j.1552-6569.2011.00663.x.

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