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@proceedings{1198115,
author = {Pásek, Michal and Bébarová, Markéta and Christé, Georges and Šimurdová, Milena and Šimurda, Jiří},
booktitle = {Physiology 2014},
keywords = {ethanol; cardiac cell; action potential; rat ventricular cell model; human ventricular cell model},
language = {eng},
title = {Effect of ethanol on action potential in ventricular cardiomyocytes: experimental and computational approach},
url = {http://www.physiology2014.org/},
year = {2014}
}
TY - CONF
ID - 1198115
AU - Pásek, Michal - Bébarová, Markéta - Christé, Georges - Šimurdová, Milena - Šimurda, Jiří
PY - 2014
TI - Effect of ethanol on action potential in ventricular cardiomyocytes: experimental and computational approach
KW - ethanol
KW - cardiac cell
KW - action potential
KW - rat ventricular cell model
KW - human ventricular cell model
UR - http://www.physiology2014.org/
N2 - In this work, the concentration dependences of ethanol-induced inhibition/activation of ionic currents derived from experimental data were incorporated into the published models of rat and human ventricular cardiomyocyte with the aim to assess the share of ionic current components in ethanol-induced changes of AP configuration. Our results suggest that contribution of individual ionic current components to the effect of ethanol on AP repolarization in cardiac cell is strongly dependent on species differences in current densities. Because AP configuration in the human model shows only a small sensitivity to variations of IK1, the effect of ethanol-induced inhibition of IKr predominates implying prolongation of APD. This effect might contribute to the clinically observed prolongation of QTc interval in ECG under consumption of alcohol.
ER -
PÁSEK, Michal, Markéta BÉBAROVÁ, Georges CHRISTÉ, Milena ŠIMURDOVÁ a Jiří ŠIMURDA. Effect of ethanol on action potential in ventricular cardiomyocytes: experimental and computational approach. In \textit{Physiology 2014}. 2014.
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