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@article{1198994,
author = {Dite, Petr and Nechutová, Hana and Uvirová, Magdalena and Dvorackova, Jana and Kianička, Bohuslav and Martinek, Arnost},
article_location = {Olomouc},
article_number = {1},
doi = {http://dx.doi.org/10.5507/bp.2013.094},
keywords = {chronic pancreatitis; autoimmune pancreatitis; immunoglobulines; IgG4; steroids; extrapancreatic lesions; pancreatic biopsy},
language = {eng},
issn = {1213-8118},
journal = {Biomedical Papers of the Faculty of Medicine of Palacký University, Olomouc, Czech Republic},
title = {Autoimmune pancreatitis},
volume = {158},
year = {2014}
}
TY - JOUR
ID - 1198994
AU - Dite, Petr - Nechutová, Hana - Uvirová, Magdalena - Dvorackova, Jana - Kianička, Bohuslav - Martinek, Arnost
PY - 2014
TI - Autoimmune pancreatitis
JF - Biomedical Papers of the Faculty of Medicine of Palacký University, Olomouc, Czech Republic
VL - 158
IS - 1
SP - 17-22
EP - 17-22
PB - Palacky University
SN - 12138118
KW - chronic pancreatitis
KW - autoimmune pancreatitis
KW - immunoglobulines
KW - IgG4
KW - steroids
KW - extrapancreatic lesions
KW - pancreatic biopsy
N2 - Introduction. Autoimmune pancreatitis (AIP) is the specific type of chronic pancreatitis due to autoimmune background and mechanism. Characteristics. The main clinical symptoms of AIP are obstructive jaundice and abdominal discomfort. The typical histological findings are lymphocytes and IgG4 plasma cells infiltration, fibrosis and venulitis within pancreatic gland. Plasma level of IgG4 is usually extremely high. Objectives. Diagnosis: High level IgG4 positive plasma cells in serum, lymphoplasmatic infiltration found on histological staining of pancreatic tissue, "sausage-like" pancreas in ultrasound and CT scans, and response to steroid therapy are crucial for making of diagnosis. Classification of AIP: AIP can be classified into two subtypes. Type 1 was recognized as the pancreatic manifestation of multiorgan disorder, called IgG4 related disease. Type 2 is a pancreas-specific disorder not associated with IgG4, with similar histological signs as type 1, but also with the positivity of GEL (granulocythic epithelial lesion). Results. Therapy: Due to its high effectivity in AIP treatment, steroid therapy is the first-line option. The alternative therapy is using immunosuppressants (azathioprine). Recently, there are also first experience in biological therapy already published. Conslusion. Before the start of AIP therapy - the differential diagnosis between pancreatic cancer and AIP is essential.
ER -
DITE, Petr, Hana NECHUTOVÁ, Magdalena UVIROVÁ, Jana DVORACKOVA, Bohuslav KIANIČKA a Arnost MARTINEK. Autoimmune pancreatitis. \textit{Biomedical Papers of the Faculty of Medicine of Palacký University, Olomouc, Czech Republic}. Olomouc: Palacky University, 2014, roč.~158, č.~1, s.~17-22. ISSN~1213-8118. Dostupné z: https://dx.doi.org/10.5507/bp.2013.094.
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