Coding-sequence variability in TLR4 in tropical and temperate
zone passerines

k 2014

Coding-sequence variability in TLR4 in tropical and temperate zone passerines

KRÁLOVÁ, Tereza, Dagmar ČÍŽKOVÁ, Jakub KREISINGER, Michal VINKLER, Jan T. LIFJELD et. al.

Základní údaje

Originální název

Coding-sequence variability in TLR4 in tropical and temperate zone passerines

Autoři

KRÁLOVÁ, Tereza, Dagmar ČÍŽKOVÁ, Jakub KREISINGER, Michal VINKLER, Jan T. LIFJELD, Arild JOHNSEN, Josef BRYJA a Tomáš ALBRECHT

Vydání

Avian Immunology Research Group Meeting 2014, Guelph, Canada, 2014

Další údaje

Typ výsledku

Prezentace na konferencích

Utajení

není předmětem státního či obchodního tajemství

Změněno: 30. 9. 2014 01:49, Mgr. Tereza Kauzálová

Anotace

V originále

Toll-like receptor 4 (TLR4) is an innate immunity receptor important for recognition of bacterial lipopolysaccharides in vertebrates. Generally, Toll-like receptors (TLRs) which bind conservative microbe-associated molecular patterns (MAMPs) represent proteins evolving under strong purifying selection. However, it has been repeatedly shown that even MAMPs are structurally variable and this can be particularly true for pathogens occurring at different latitudes. The environmental conditions in the tropics are suitable for the development of higher species diversity than in the temperate zone. According to this hypothesis, the tropical and migratory birds are exposed to higher pathogen diversity than their closely related temperate zone species, and thus should have also higher TLR4 variability. In present study, we have selected 21 tropical and 25 temperate zone passerine species which represent 26 families throughout passerine phylogeny. Using 454-pyrosequencing approach, all 675 individuals (15 individuals per species) were sequenced on the 681 bp long Ligand-binding region of TLR4. In this contribution we provide first preliminary results on intra- and interspecific comparison of TLR4 variability in passerines at different latitudes.

Návaznosti

GAP505/10/1871, projekt VaV

Název: Toll-like receptory u pěvců: popis, polymorfismus a evoluční důsledky alelické variability

MUNI/A/0888/2013, interní kód MU

Název: Biodiverzita - analýzy biologických systémů různých úrovní a na různých škálách prostředí (Akronym: BIDA3)

Investor: Masarykova univerzita, Biodiverzita - analýzy biologických systémů různých úrovní a na různých škálách prostředí, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

KRÁLOVÁ, Tereza, Dagmar ČÍŽKOVÁ, Jakub KREISINGER, Michal VINKLER, Jan T. LIFJELD, Arild JOHNSEN, Josef BRYJA a Tomáš ALBRECHT. Coding-sequence variability in TLR4 in tropical and temperate zone passerines. In Avian Immunology Research Group Meeting 2014, Guelph, Canada. 2014.

@proceedings{1199896,
   author = {Králová, Tereza and Čížková, Dagmar and Kreisinger, Jakub and Vinkler, Michal and Lifjeld, Jan T. and Johnsen, Arild and Bryja, Josef and Albrecht, Tomáš},
   booktitle = {Avian Immunology Research Group Meeting 2014, Guelph, Canada},
   title = {Coding-sequence variability in TLR4 in tropical and temperate zone passerines},
   year = {2014}
}

TY  - CONF
ID  - 1199896
AU  - Králová, Tereza - Čížková, Dagmar - Kreisinger, Jakub - Vinkler, Michal - Lifjeld, Jan T. - Johnsen, Arild - Bryja, Josef - Albrecht, Tomáš
PY  - 2014
TI  - Coding-sequence variability in TLR4 in tropical and temperate zone passerines
N2  - Toll-like receptor 4 (TLR4) is an innate immunity receptor important for recognition of bacterial lipopolysaccharides in vertebrates. Generally, Toll-like receptors (TLRs) which bind conservative microbe-associated molecular patterns (MAMPs) represent proteins evolving under strong purifying selection. However, it has been repeatedly shown that even MAMPs are structurally variable and this can be particularly true for pathogens occurring at different latitudes. The environmental conditions in the tropics are suitable for the development of higher species diversity than in the temperate zone. According to this hypothesis, the tropical and migratory birds are exposed to higher pathogen diversity than their closely related temperate zone species, and thus should have also higher TLR4 variability. In present study, we have selected 21 tropical and 25 temperate zone passerine species which represent 26 families throughout passerine phylogeny. Using 454-pyrosequencing approach, all 675 individuals (15 individuals per species) were sequenced on the 681 bp long Ligand-binding region of TLR4. In this contribution we provide first preliminary results on intra- and interspecific comparison of TLR4 variability in passerines at different latitudes.
ER  -

KRÁLOVÁ, Tereza, Dagmar ČÍŽKOVÁ, Jakub KREISINGER, Michal VINKLER, Jan T. LIFJELD, Arild JOHNSEN, Josef BRYJA a Tomáš ALBRECHT. Coding-sequence variability in TLR4 in tropical and temperate zone passerines. In \textit{Avian Immunology Research Group Meeting 2014, Guelph, Canada}. 2014.

Podrobný výpis o publikaci