MELUZÍN, Jaroslav, Tomáš KÁRA, Milos BELEHRAD, Zdeněk STÁREK, Radka STEPANOVA, Tereza MIKUŠOVÁ, Helena PODROUŽKOVÁ, Monika ŠPINAROVÁ, Miroslav SOUCEK a Vladimír SOŠKA. Significant association of diastolic dysfunction and heart failure with severe sleep apnea-induced hypoxemia in patients with drug-resistant hypertension. Experimental and Clinical Cardiology. Oakville: Pulsus Group, 2014, roč. 20, č. 8, s. 3204-3217. ISSN 1205-6626. |
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@article{1199947, author = {Meluzín, Jaroslav and Kára, Tomáš and Belehrad, Milos and Stárek, Zdeněk and Stepanova, Radka and Mikušová, Tereza and Podroužková, Helena and Špinarová, Monika and Soucek, Miroslav and Soška, Vladimír}, article_location = {Oakville}, article_number = {8}, keywords = {Diastolic dysfunction; Heart failure; Sleep apnea}, language = {eng}, issn = {1205-6626}, journal = {Experimental and Clinical Cardiology}, title = {Significant association of diastolic dysfunction and heart failure with severe sleep apnea-induced hypoxemia in patients with drug-resistant hypertension}, volume = {20}, year = {2014} }
TY - JOUR ID - 1199947 AU - Meluzín, Jaroslav - Kára, Tomáš - Belehrad, Milos - Stárek, Zdeněk - Stepanova, Radka - Mikušová, Tereza - Podroužková, Helena - Špinarová, Monika - Soucek, Miroslav - Soška, Vladimír PY - 2014 TI - Significant association of diastolic dysfunction and heart failure with severe sleep apnea-induced hypoxemia in patients with drug-resistant hypertension JF - Experimental and Clinical Cardiology VL - 20 IS - 8 SP - 3204-3217 EP - 3204-3217 PB - Pulsus Group SN - 12056626 KW - Diastolic dysfunction KW - Heart failure KW - Sleep apnea N2 - Objectives: The aim of this study was to assess the relationship of the severity of myocardial dysfunction to the severity of sleep apnea syndrome (SAS) in patients with drug-resistant hypertension. Methods and Results: Thirty-five patients with drug-resistant hypertension underwent complete overnight polysomnography and comprehensive echocardiography including Doppler tissue imaging and speckle tracking analysis within 24 hours. Severe SAS was defined by the presence of severe SA-induced hypoxemia as indicated by percentage of sleep time with oxygen saturation < 90% (t90)>/= 12%. Heart failure with normal ejection fraction (HFNEF) and t90 >/= 12% were found in 66% and 31% of subjects, respectively. Multivariate regression analysis revealed a significant and independent association of left atrial volume index (LAVI) with t90 >/= 12% (OR 1.292, CI 1.041-1.604, p = 0.020). Severe SA-induced hypoxemia was found in 11 (48%) patients with HFNEF, but in none of those without HFNEF (p < 0.01). Conclusion: In patients with drug-resistant hypertension, there exists a significant association of diastolic dysfunction and heart failure with severe SAS. LAVI represents an independent predictor of severe SA-induced hypoxemia. ER -
MELUZÍN, Jaroslav, Tomáš KÁRA, Milos BELEHRAD, Zdeněk STÁREK, Radka STEPANOVA, Tereza MIKUŠOVÁ, Helena PODROUŽKOVÁ, Monika ŠPINAROVÁ, Miroslav SOUCEK a Vladimír SOŠKA. Significant association of diastolic dysfunction and heart failure with severe sleep apnea-induced hypoxemia in patients with drug-resistant hypertension. \textit{Experimental and Clinical Cardiology}. Oakville: Pulsus Group, 2014, roč.~20, č.~8, s.~3204-3217. ISSN~1205-6626.
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