| MELUZÍN, Jaroslav, Tomáš KÁRA, Milos BELEHRAD, Zdeněk STÁREK, Radka STEPANOVA, Tereza MIKUŠOVÁ, Helena PODROUŽKOVÁ, Monika ŠPINAROVÁ, Miroslav SOUCEK and Vladimír SOŠKA. Significant association of diastolic dysfunction and heart failure with severe sleep apnea-induced hypoxemia in patients with drug-resistant hypertension. Experimental and Clinical Cardiology. Oakville: Pulsus Group, 2014, vol. 20, No 8, p. 3204-3217. ISSN 1205-6626. |
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@article{1199947,
author = {Meluzín, Jaroslav and Kára, Tomáš and Belehrad, Milos and Stárek, Zdeněk and Stepanova, Radka and Mikušová, Tereza and Podroužková, Helena and Špinarová, Monika and Soucek, Miroslav and Soška, Vladimír},
article_location = {Oakville},
article_number = {8},
keywords = {Diastolic dysfunction; Heart failure; Sleep apnea},
language = {eng},
issn = {1205-6626},
journal = {Experimental and Clinical Cardiology},
title = {Significant association of diastolic dysfunction and heart failure with severe sleep apnea-induced hypoxemia in patients with drug-resistant hypertension},
volume = {20},
year = {2014}
}
TY - JOUR
ID - 1199947
AU - Meluzín, Jaroslav - Kára, Tomáš - Belehrad, Milos - Stárek, Zdeněk - Stepanova, Radka - Mikušová, Tereza - Podroužková, Helena - Špinarová, Monika - Soucek, Miroslav - Soška, Vladimír
PY - 2014
TI - Significant association of diastolic dysfunction and heart failure with severe sleep apnea-induced hypoxemia in patients with drug-resistant hypertension
JF - Experimental and Clinical Cardiology
VL - 20
IS - 8
SP - 3204-3217
EP - 3204-3217
PB - Pulsus Group
SN - 12056626
KW - Diastolic dysfunction
KW - Heart failure
KW - Sleep apnea
N2 - Objectives: The aim of this study was to assess the relationship of the severity of myocardial dysfunction to the severity of sleep apnea syndrome (SAS) in patients with drug-resistant hypertension. Methods and Results: Thirty-five patients with drug-resistant hypertension underwent complete overnight polysomnography and comprehensive echocardiography including Doppler tissue imaging and speckle tracking analysis within 24 hours. Severe SAS was defined by the presence of severe SA-induced hypoxemia as indicated by percentage of sleep time with oxygen saturation < 90% (t90)>/= 12%. Heart failure with normal ejection fraction (HFNEF) and t90 >/= 12% were found in 66% and 31% of subjects, respectively. Multivariate regression analysis revealed a significant and independent association of left atrial volume index (LAVI) with t90 >/= 12% (OR 1.292, CI 1.041-1.604, p = 0.020). Severe SA-induced hypoxemia was found in 11 (48%) patients with HFNEF, but in none of those without HFNEF (p < 0.01). Conclusion: In patients with drug-resistant hypertension, there exists a significant association of diastolic dysfunction and heart failure with severe SAS. LAVI represents an independent predictor of severe SA-induced hypoxemia.
ER -
MELUZÍN, Jaroslav, Tomáš KÁRA, Milos BELEHRAD, Zdeněk STÁREK, Radka STEPANOVA, Tereza MIKUŠOVÁ, Helena PODROUŽKOVÁ, Monika ŠPINAROVÁ, Miroslav SOUCEK and Vladimír SOŠKA. Significant association of diastolic dysfunction and heart failure with severe sleep apnea-induced hypoxemia in patients with drug-resistant hypertension. \textit{Experimental and Clinical Cardiology}. Oakville: Pulsus Group, 2014, vol.~20, No~8, p.~3204-3217. ISSN~1205-6626.
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