Self-expandable biodegradable biliary stents in porcine model

J 2015

Self-expandable biodegradable biliary stents in porcine model

GROLICH, Tomáš, Michal CRHA, Ladislav NOVOTNÝ, Zdeněk KALA, Aleš HEP et. al.

Základní údaje

Originální název

Self-expandable biodegradable biliary stents in porcine model

Autoři

GROLICH, Tomáš (203 Česká republika, garant, domácí), Michal CRHA (203 Česká republika), Ladislav NOVOTNÝ (203 Česká republika), Zdeněk KALA (203 Česká republika, domácí), Aleš HEP (203 Česká republika, domácí), Alois NEČAS (203 Česká republika), Jan HLAVSA (203 Česká republika, domácí), Ladislav MITÁŠ (203 Česká republika, domácí) a Jan MISÍK (203 Česká republika)

Vydání

Journal of Surgical Research, San Diego, Academic Press, 2015, 0022-4804

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.198

Kód RIV

RIV/00216224:14110/15:00082127

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.jss.2014.08.006

UT WoS

000346244300014

Klíčová slova anglicky

Biliary tree; Biodegradable stent; Polydioxanon

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 27. 2. 2015 15:09, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Background: Treatment or prevention of a benign biliary tree stricture is an unresolved problem. A novel self-expandable biodegradable polydioxanon biliary stent in a porcine model was studied. Materials and methods: This new stent was used in 23 pigs. Feasibility and safety of surgical stenting, time of biodegradation, and histologic reaction in 2, 8, 13, and 20 wk of a follow-up were studied. All stents were inserted into a common bile duct through a duodenal papilla following small dilatation. After surgical evaluation of abdominal cavities, the pigs were sacrificed to remove common bile ducts with the stents. All bile ducts were assessed by macroscopic and histopathologic examination. Results: Self-expansion was correct in all cases. Neither bile duct obstruction nor postsurgical complications were observed. Macroscopic evaluation indicated lightening of the stent color in 2 wk, a partial disintegration in 8 wk, and a complete absorption in 13 and 20 wk. Histologic evaluation in general substantiated a mild-to-moderate inflammatory reaction in the lamina propria during the whole follow up and had no clinical consequences. No cholangitis, necrosis, abscess, or excessive fibroplasia was found in a hepatoduodenal ligament. Conclusions: Our results suggest that polydioxanon biodegradable self-expanding stents seem to be useful for biliary system implantation, offer a good biocompatibility, and completely degrade within 13 wk.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

EE2.3.09.0193, projekt VaV

Název: Vzdělávání pracovníků VaV MU a VFU Brno v endoskopických vyšetřovacích technikách a endoskopicky asistované miniinvazivní chirurgii s využítím nových materiálů

Citovat

GROLICH, Tomáš, Michal CRHA, Ladislav NOVOTNÝ, Zdeněk KALA, Aleš HEP, Alois NEČAS, Jan HLAVSA, Ladislav MITÁŠ a Jan MISÍK. Self-expandable biodegradable biliary stents in porcine model. Journal of Surgical Research. San Diego: Academic Press, 2015, roč. 193, č. 2, s. 606-612. ISSN 0022-4804. Dostupné z: https://dx.doi.org/10.1016/j.jss.2014.08.006.

@article{1201934,
   author = {Grolich, Tomáš and Crha, Michal and Novotný, Ladislav and Kala, Zdeněk and Hep, Aleš and Nečas, Alois and Hlavsa, Jan and Mitáš, Ladislav and Misík, Jan},
   article_location = {San Diego},
   article_number = {2},
   doi = {http://dx.doi.org/10.1016/j.jss.2014.08.006},
   keywords = {Biliary tree; Biodegradable stent; Polydioxanon},
   language = {eng},
   issn = {0022-4804},
   journal = {Journal of Surgical Research},
   title = {Self-expandable biodegradable biliary stents in porcine model},
   volume = {193},
   year = {2015}
}

TY  - JOUR
ID  - 1201934
AU  - Grolich, Tomáš - Crha, Michal - Novotný, Ladislav - Kala, Zdeněk - Hep, Aleš - Nečas, Alois - Hlavsa, Jan - Mitáš, Ladislav - Misík, Jan
PY  - 2015
TI  - Self-expandable biodegradable biliary stents in porcine model
JF  - Journal of Surgical Research
VL  - 193
IS  - 2
SP  - 606-612
EP  - 606-612
PB  - Academic Press
SN  - 00224804
KW  - Biliary tree
KW  - Biodegradable stent
KW  - Polydioxanon
N2  - Background: Treatment or prevention of a benign biliary tree stricture is an unresolved problem. A novel self-expandable biodegradable polydioxanon biliary stent in a porcine model was studied. Materials and methods: This new stent was used in 23 pigs. Feasibility and safety of surgical stenting, time of biodegradation, and histologic reaction in 2, 8, 13, and 20 wk of a follow-up were studied. All stents were inserted into a common bile duct through a duodenal papilla following small dilatation. After surgical evaluation of abdominal cavities, the pigs were sacrificed to remove common bile ducts with the stents. All bile ducts were assessed by macroscopic and histopathologic examination. Results: Self-expansion was correct in all cases. Neither bile duct obstruction nor postsurgical complications were observed. Macroscopic evaluation indicated lightening of the stent color in 2 wk, a partial disintegration in 8 wk, and a complete absorption in 13 and 20 wk. Histologic evaluation in general substantiated a mild-to-moderate inflammatory reaction in the lamina propria during the whole follow up and had no clinical consequences. No cholangitis, necrosis, abscess, or excessive fibroplasia was found in a hepatoduodenal ligament. Conclusions: Our results suggest that polydioxanon biodegradable self-expanding stents seem to be useful for biliary system implantation, offer a good biocompatibility, and completely degrade within 13 wk.
ER  -

GROLICH, Tomáš, Michal CRHA, Ladislav NOVOTNÝ, Zdeněk KALA, Aleš HEP, Alois NEČAS, Jan HLAVSA, Ladislav MITÁŠ a Jan MISÍK. Self-expandable biodegradable biliary stents in porcine model. \textit{Journal of Surgical Research}. San Diego: Academic Press, 2015, roč.~193, č.~2, s.~606-612. ISSN~0022-4804. Dostupné z: https://dx.doi.org/10.1016/j.jss.2014.08.006.

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