Self-expandable biodegradable biliary stents in porcine model

J 2015

Self-expandable biodegradable biliary stents in porcine model

GROLICH, Tomáš, Michal CRHA, Ladislav NOVOTNÝ, Zdeněk KALA, Aleš HEP et. al.

Basic information

Original name

Self-expandable biodegradable biliary stents in porcine model

Authors

GROLICH, Tomáš (203 Czech Republic, guarantor, belonging to the institution), Michal CRHA (203 Czech Republic), Ladislav NOVOTNÝ (203 Czech Republic), Zdeněk KALA (203 Czech Republic, belonging to the institution), Aleš HEP (203 Czech Republic, belonging to the institution), Alois NEČAS (203 Czech Republic), Jan HLAVSA (203 Czech Republic, belonging to the institution), Ladislav MITÁŠ (203 Czech Republic, belonging to the institution) and Jan MISÍK (203 Czech Republic)

Edition

Journal of Surgical Research, San Diego, Academic Press, 2015, 0022-4804

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.198

RIV identification code

RIV/00216224:14110/15:00082127

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.jss.2014.08.006

UT WoS

000346244300014

Keywords in English

Biliary tree; Biodegradable stent; Polydioxanon

Abstract

V originále

Background: Treatment or prevention of a benign biliary tree stricture is an unresolved problem. A novel self-expandable biodegradable polydioxanon biliary stent in a porcine model was studied. Materials and methods: This new stent was used in 23 pigs. Feasibility and safety of surgical stenting, time of biodegradation, and histologic reaction in 2, 8, 13, and 20 wk of a follow-up were studied. All stents were inserted into a common bile duct through a duodenal papilla following small dilatation. After surgical evaluation of abdominal cavities, the pigs were sacrificed to remove common bile ducts with the stents. All bile ducts were assessed by macroscopic and histopathologic examination. Results: Self-expansion was correct in all cases. Neither bile duct obstruction nor postsurgical complications were observed. Macroscopic evaluation indicated lightening of the stent color in 2 wk, a partial disintegration in 8 wk, and a complete absorption in 13 and 20 wk. Histologic evaluation in general substantiated a mild-to-moderate inflammatory reaction in the lamina propria during the whole follow up and had no clinical consequences. No cholangitis, necrosis, abscess, or excessive fibroplasia was found in a hepatoduodenal ligament. Conclusions: Our results suggest that polydioxanon biodegradable self-expanding stents seem to be useful for biliary system implantation, offer a good biocompatibility, and completely degrade within 13 wk.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

EE2.3.09.0193, research and development project

Name: Vzdělávání pracovníků VaV MU a VFU Brno v endoskopických vyšetřovacích technikách a endoskopicky asistované miniinvazivní chirurgii s využítím nových materiálů

Citovat

GROLICH, Tomáš, Michal CRHA, Ladislav NOVOTNÝ, Zdeněk KALA, Aleš HEP, Alois NEČAS, Jan HLAVSA, Ladislav MITÁŠ and Jan MISÍK. Self-expandable biodegradable biliary stents in porcine model. Journal of Surgical Research. San Diego: Academic Press, 2015, vol. 193, No 2, p. 606-612. ISSN 0022-4804. Available from: https://dx.doi.org/10.1016/j.jss.2014.08.006.

@article{1201934,
   author = {Grolich, Tomáš and Crha, Michal and Novotný, Ladislav and Kala, Zdeněk and Hep, Aleš and Nečas, Alois and Hlavsa, Jan and Mitáš, Ladislav and Misík, Jan},
   article_location = {San Diego},
   article_number = {2},
   doi = {http://dx.doi.org/10.1016/j.jss.2014.08.006},
   keywords = {Biliary tree; Biodegradable stent; Polydioxanon},
   language = {eng},
   issn = {0022-4804},
   journal = {Journal of Surgical Research},
   title = {Self-expandable biodegradable biliary stents in porcine model},
   volume = {193},
   year = {2015}
}

TY  - JOUR
ID  - 1201934
AU  - Grolich, Tomáš - Crha, Michal - Novotný, Ladislav - Kala, Zdeněk - Hep, Aleš - Nečas, Alois - Hlavsa, Jan - Mitáš, Ladislav - Misík, Jan
PY  - 2015
TI  - Self-expandable biodegradable biliary stents in porcine model
JF  - Journal of Surgical Research
VL  - 193
IS  - 2
SP  - 606-612
EP  - 606-612
PB  - Academic Press
SN  - 00224804
KW  - Biliary tree
KW  - Biodegradable stent
KW  - Polydioxanon
N2  - Background: Treatment or prevention of a benign biliary tree stricture is an unresolved problem. A novel self-expandable biodegradable polydioxanon biliary stent in a porcine model was studied. Materials and methods: This new stent was used in 23 pigs. Feasibility and safety of surgical stenting, time of biodegradation, and histologic reaction in 2, 8, 13, and 20 wk of a follow-up were studied. All stents were inserted into a common bile duct through a duodenal papilla following small dilatation. After surgical evaluation of abdominal cavities, the pigs were sacrificed to remove common bile ducts with the stents. All bile ducts were assessed by macroscopic and histopathologic examination. Results: Self-expansion was correct in all cases. Neither bile duct obstruction nor postsurgical complications were observed. Macroscopic evaluation indicated lightening of the stent color in 2 wk, a partial disintegration in 8 wk, and a complete absorption in 13 and 20 wk. Histologic evaluation in general substantiated a mild-to-moderate inflammatory reaction in the lamina propria during the whole follow up and had no clinical consequences. No cholangitis, necrosis, abscess, or excessive fibroplasia was found in a hepatoduodenal ligament. Conclusions: Our results suggest that polydioxanon biodegradable self-expanding stents seem to be useful for biliary system implantation, offer a good biocompatibility, and completely degrade within 13 wk.
ER  -

GROLICH, Tomáš, Michal CRHA, Ladislav NOVOTNÝ, Zdeněk KALA, Aleš HEP, Alois NEČAS, Jan HLAVSA, Ladislav MITÁŠ and Jan MISÍK. Self-expandable biodegradable biliary stents in porcine model. \textit{Journal of Surgical Research}. San Diego: Academic Press, 2015, vol.~193, No~2, p.~606-612. ISSN~0022-4804. Available from: https://dx.doi.org/10.1016/j.jss.2014.08.006.

Detailed Information on Publication Record