SENSITIVITY OF ACTION POTENTIAL TO CHANGES OF INWARD RECTIFIER
POTASSIUM CURRENT IK1 IS DIFFERENT IN RECENT MODELS OF HUMAN
VENTRICULAR CARDIOMYOCYTES

D 2014

SENSITIVITY OF ACTION POTENTIAL TO CHANGES OF INWARD RECTIFIER POTASSIUM CURRENT IK1 IS DIFFERENT IN RECENT MODELS OF HUMAN VENTRICULAR CARDIOMYOCYTES

PÁSEK, Michal, Jiří ŠIMURDA a G. CHRISTÉ

Základní údaje

Originální název

SENSITIVITY OF ACTION POTENTIAL TO CHANGES OF INWARD RECTIFIER POTASSIUM CURRENT IK1 IS DIFFERENT IN RECENT MODELS OF HUMAN VENTRICULAR CARDIOMYOCYTES

Autoři

PÁSEK, Michal (203 Česká republika, garant, domácí), Jiří ŠIMURDA (203 Česká republika, domácí) a G. CHRISTÉ (250 Francie)

Vydání

Brno, Engineering Mechanics 2014, od s. 476-479, 4 s. 2014

Nakladatel

University of Technology, Institute of Solid Mechanics, Mechatronics and Biomechanics

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

30105 Physiology

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Forma vydání

tištěná verze "print"

Kód RIV

RIV/00216224:14110/14:00080145

Organizační jednotka

Lékařská fakulta

ISBN

978-80-214-4871-1

ISSN

Klíčová slova anglicky

Cardiac cell; Action potential; Inward rectifier potassium current; Quantitative modelling

Štítky

EL OK

Změněno: 14. 10. 2014 15:00, Soňa Böhmová

Anotace

V originále

The inwardly rectifying potassium current IK1 is one of the principle ionic currents responsible for repolarization phase of mammalian action potentials (APs). To estimate the impact of individual ionic currents on AP configuration, mathematical models have been widely used. In this study, we compare the effects of alcohol-induced changes of IK1 on AP duration (APD) as simulated in four recently published computer models of human ventricular cells. As expected, increasing or decreasing IK1 conductance by 20% respectively caused a shortening or a lengthening of APD. However, the effect was largely model-dependent, ranging from 1% to about 15% change of APD. Given the conflicting available experimental data on the features of IK1 in human ventricular myocytes there is a need for a set of well-established end-point constraints for a reliable human ventricular myocyte model to be generated.

Návaznosti

NT14301, projekt VaV

Název: Vliv ethanolu a jeho metabolitu acetaldehydu na srdeční inward rectifier draslíkové proudy: vztah k fibrilaci síní po konzumaci alkoholu?

Investor: Ministerstvo zdravotnictví ČR, Vliv ethanolu a jeho metabolitu acetaldehydu na srdeční inward rectifier draslíkové proudy: vztah k fibrilaci síní po konzumaci alkoholu?

Citovat

PÁSEK, Michal, Jiří ŠIMURDA a G. CHRISTÉ. SENSITIVITY OF ACTION POTENTIAL TO CHANGES OF INWARD RECTIFIER POTASSIUM CURRENT IK1 IS DIFFERENT IN RECENT MODELS OF HUMAN VENTRICULAR CARDIOMYOCYTES. In Vladimír Fuis. Engineering Mechanics 2014. Brno: University of Technology, Institute of Solid Mechanics, Mechatronics and Biomechanics, 2014, s. 476-479. ISBN 978-80-214-4871-1.

@inproceedings{1202671,
   author = {Pásek, Michal and Šimurda, Jiří and Christé, G.},
   address = {Brno},
   booktitle = {Engineering Mechanics 2014},
   editor = {Vladimír Fuis},
   keywords = {Cardiac cell; Action potential; Inward rectifier potassium current; Quantitative modelling},
   howpublished = {tištěná verze "print"},
   language = {eng},
   location = {Brno},
   isbn = {978-80-214-4871-1},
   pages = {476-479},
   publisher = {University of Technology, Institute of Solid Mechanics, Mechatronics and Biomechanics},
   title = {SENSITIVITY OF ACTION POTENTIAL TO CHANGES OF INWARD RECTIFIER POTASSIUM CURRENT IK1 IS DIFFERENT IN RECENT MODELS OF HUMAN VENTRICULAR CARDIOMYOCYTES},
   year = {2014}
}

TY  - JOUR
ID  - 1202671
AU  - Pásek, Michal - Šimurda, Jiří - Christé, G.
PY  - 2014
TI  - SENSITIVITY OF ACTION POTENTIAL TO CHANGES OF INWARD RECTIFIER POTASSIUM CURRENT IK1 IS DIFFERENT IN RECENT MODELS OF HUMAN VENTRICULAR CARDIOMYOCYTES
PB  - University of Technology, Institute of Solid Mechanics, Mechatronics and Biomechanics
CY  - Brno
SN  - 9788021448711
KW  - Cardiac cell
KW  - Action potential
KW  - Inward rectifier potassium current
KW  - Quantitative modelling
N2  - The inwardly rectifying potassium current IK1 is one of the principle ionic currents responsible for repolarization phase of mammalian action potentials (APs). To estimate the impact of individual ionic currents on AP configuration, mathematical models have been widely used. In this study, we compare the effects of alcohol-induced changes of IK1 on AP duration (APD) as simulated in four recently published computer models of human ventricular cells. As expected, increasing or decreasing IK1 conductance by 20% respectively caused a shortening or a lengthening of APD. However, the effect was largely model-dependent, ranging from 1% to about 15% change of APD. Given the conflicting available experimental data on the features of IK1 in human ventricular myocytes there is a need for a set of well-established end-point constraints for a reliable human ventricular myocyte model to be generated.
ER  -

PÁSEK, Michal, Jiří ŠIMURDA a G. CHRISTÉ. SENSITIVITY OF ACTION POTENTIAL TO CHANGES OF INWARD RECTIFIER POTASSIUM CURRENT IK1 IS DIFFERENT IN RECENT MODELS OF HUMAN VENTRICULAR CARDIOMYOCYTES. In Vladimír Fuis. \textit{Engineering Mechanics 2014}. Brno: University of Technology, Institute of Solid Mechanics, Mechatronics and Biomechanics, 2014, s.~476-479. ISBN~978-80-214-4871-1.

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