SARANGI, Prabha, Veronika ALTMANNOVÁ, Cory HOLLAND, Zdenka BARTOŠOVÁ, Fanfan HAO, Dorothea ANRATHER, Gustav AMMERER, Sang Eun LEE, Lumír KREJČÍ a Xiaolan ZHAO. A Versatile Scaffold Contributes to Damage Survival via Sumoylation and Nuclease Interactions. Cell Reports. CAMBRIDGE, Spojené státy americké: Cell Press, 2014, roč. 9, č. 1, s. 143-152. ISSN 2211-1247. Dostupné z: https://dx.doi.org/10.1016/j.celrep.2014.08.054. |
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@article{1204451, author = {Sarangi, Prabha and Altmannová, Veronika and Holland, Cory and Bartošová, Zdenka and Hao, Fanfan and Anrather, Dorothea and Ammerer, Gustav and Lee, Sang Eun and Krejčí, Lumír and Zhao, Xiaolan}, article_location = {CAMBRIDGE, Spojené státy americké}, article_number = {1}, doi = {http://dx.doi.org/10.1016/j.celrep.2014.08.054}, keywords = {STRAND BREAK REPAIR; YEAST SCHIZOSACCHAROMYCES-POMBE; HOLLIDAY JUNCTION RESOLVASE; DNA-REPAIR; SACCHAROMYCES-CEREVISIAE; PROTEIN INTERACTIONS; RAD1-RAD10 NUCLEASE; ABASIC SITES; RECOMBINATION; ENDONUCLEASE}, language = {eng}, issn = {2211-1247}, journal = {Cell Reports}, title = {A Versatile Scaffold Contributes to Damage Survival via Sumoylation and Nuclease Interactions}, volume = {9}, year = {2014} }
TY - JOUR ID - 1204451 AU - Sarangi, Prabha - Altmannová, Veronika - Holland, Cory - Bartošová, Zdenka - Hao, Fanfan - Anrather, Dorothea - Ammerer, Gustav - Lee, Sang Eun - Krejčí, Lumír - Zhao, Xiaolan PY - 2014 TI - A Versatile Scaffold Contributes to Damage Survival via Sumoylation and Nuclease Interactions JF - Cell Reports VL - 9 IS - 1 SP - 143-152 EP - 143-152 PB - Cell Press SN - 22111247 KW - STRAND BREAK REPAIR KW - YEAST SCHIZOSACCHAROMYCES-POMBE KW - HOLLIDAY JUNCTION RESOLVASE KW - DNA-REPAIR KW - SACCHAROMYCES-CEREVISIAE KW - PROTEIN INTERACTIONS KW - RAD1-RAD10 NUCLEASE KW - ABASIC SITES KW - RECOMBINATION KW - ENDONUCLEASE N2 - DNA repair scaffolds mediate specific DNA and protein interactions in order to assist repair enzymes in recognizing and removing damaged sequences. Many scaffold proteins are dedicated to repairing a particular type of lesion. Here, we show that the budding yeast Saw1 scaffold is more versatile. It helps cells cope with base lesions and protein-DNA adducts through its known function of recruiting the Rad1-Rad10 nuclease to DNA. In addition, it promotes UV survival via a mechanism mediated by its sumoylation. Saw1 sumoylation favors its interaction with another nuclease Slx1-Slx4, and this SUMO-mediated role is genetically separable from two main UV lesion repair processes. These effects of Saw1 and its sumoylation suggest that Saw1 is a multifunctional scaffold that can facilitate diverse types of DNA repair through its modification and nuclease interactions. ER -
SARANGI, Prabha, Veronika ALTMANNOVÁ, Cory HOLLAND, Zdenka BARTOŠOVÁ, Fanfan HAO, Dorothea ANRATHER, Gustav AMMERER, Sang Eun LEE, Lumír KREJČÍ a Xiaolan ZHAO. A Versatile Scaffold Contributes to Damage Survival via Sumoylation and Nuclease Interactions. \textit{Cell Reports}. CAMBRIDGE, Spojené státy americké: Cell Press, 2014, roč.~9, č.~1, s.~143-152. ISSN~2211-1247. Dostupné z: https://dx.doi.org/10.1016/j.celrep.2014.08.054.
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