Plant Coumestans: Recent Advances and Future Perspectives in
Cancer Therapy

J 2014

Plant Coumestans: Recent Advances and Future Perspectives in Cancer Therapy

NEHYBOVÁ, Tereza, Jan ŠMARDA a Petr BENEŠ

Základní údaje

Originální název

Plant Coumestans: Recent Advances and Future Perspectives in Cancer Therapy

Autoři

NEHYBOVÁ, Tereza (203 Česká republika, domácí), Jan ŠMARDA (203 Česká republika, domácí) a Petr BENEŠ (203 Česká republika, garant, domácí)

Vydání

Anti-Cancer Agents in Medicinal Chemistry, Bentham Science Publishers, 2014, 1871-5206

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10601 Cell biology

Stát vydavatele

Spojené arabské emiráty

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.469

Kód RIV

RIV/00216224:14310/14:00077288

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.2174/1871520614666140713172949

UT WoS

000345226600006

Klíčová slova anglicky

cancer; cellular target; coumestrol; coumestan; glycyrol; psoralidin; therapy; wedelolactone

Štítky

AKR

Změněno: 19. 2. 2018 10:04, doc. Mgr. Petr Beneš, Ph.D.

Anotace

V originále

Natural products are often used in drug development due to their ability to form unique and diverse chemical structures. Coumestans are polycyclic aromatic plant secondary metabolites containing a coumestan moiety, which consists of a benzoxole fused to a chromen-2-one to form 1-Benzoxolo[3,2-c]chromen-6-one. These natural compounds are known for large number of biological activities. Many of their biological effects can be attributed to their action as phytoestrogens and polyphenols. In the last decade, anticancer effects of these compounds have been described in vitro but there is only limited number of studies based on models in vivo. More information concerning their in vivo bioavailability, stability, metabolism, toxicity, estrogenicity, cellular targets and drug interactions is therefore needed to proceed further to clinical studies. This review focuses on coumestans exhibiting anticancer properties and summarizes mechanisms of their toxicity to cancer cells. Moreover, the possible role of coumestans in cancer prevention is discussed.

Návaznosti

EE2.3.20.0183, projekt VaV

Název: Centrum experimentální biomedicíny

NT13441, projekt VaV

Název: Exprese proteinů rodiny Myb v adenokarcinomech tlustého střeva a vztah k jejich metastatickému potenciálu

Citovat

NEHYBOVÁ, Tereza, Jan ŠMARDA a Petr BENEŠ. Plant Coumestans: Recent Advances and Future Perspectives in Cancer Therapy. Anti-Cancer Agents in Medicinal Chemistry. Bentham Science Publishers, 2014, roč. 14, č. 10, s. 1351-1362. ISSN 1871-5206. Dostupné z: https://dx.doi.org/10.2174/1871520614666140713172949.

@article{1205812,
   author = {Nehybová, Tereza and Šmarda, Jan and Beneš, Petr},
   article_number = {10},
   doi = {http://dx.doi.org/10.2174/1871520614666140713172949},
   keywords = {cancer; cellular target; coumestrol; coumestan; glycyrol; psoralidin; therapy; wedelolactone},
   language = {eng},
   issn = {1871-5206},
   journal = {Anti-Cancer Agents in Medicinal Chemistry},
   title = {Plant Coumestans: Recent Advances and Future Perspectives in Cancer Therapy},
   volume = {14},
   year = {2014}
}

TY  - JOUR
ID  - 1205812
AU  - Nehybová, Tereza - Šmarda, Jan - Beneš, Petr
PY  - 2014
TI  - Plant Coumestans: Recent Advances and Future Perspectives in Cancer Therapy
JF  - Anti-Cancer Agents in Medicinal Chemistry
VL  - 14
IS  - 10
SP  - 1351-1362
EP  - 1351-1362
PB  - Bentham Science Publishers
SN  - 18715206
KW  - cancer
KW  - cellular target
KW  - coumestrol
KW  - coumestan
KW  - glycyrol
KW  - psoralidin
KW  - therapy
KW  - wedelolactone
N2  - Natural products are often used in drug development due to their ability to form unique and diverse chemical structures. Coumestans are polycyclic aromatic plant secondary metabolites containing a coumestan moiety, which consists of a benzoxole fused to a chromen-2-one to form 1-Benzoxolo[3,2-c]chromen-6-one. These natural compounds are known for large number of biological activities. Many of their biological effects can be attributed to their action as phytoestrogens and polyphenols. In the last decade, anticancer effects of these compounds have been described in vitro but there is only limited number of studies based on models in vivo. More information concerning their in vivo bioavailability, stability, metabolism, toxicity, estrogenicity, cellular targets and drug interactions is therefore needed to proceed further to clinical studies. This review focuses on coumestans exhibiting anticancer properties and summarizes mechanisms of their toxicity to cancer cells. Moreover, the possible role of coumestans in cancer prevention is discussed.
ER  -

NEHYBOVÁ, Tereza, Jan ŠMARDA a Petr BENEŠ. Plant Coumestans: Recent Advances and Future Perspectives in Cancer Therapy. \textit{Anti-Cancer Agents in Medicinal Chemistry}. Bentham Science Publishers, 2014, roč.~14, č.~10, s.~1351-1362. ISSN~1871-5206. Dostupné z: https://dx.doi.org/10.2174/1871520614666140713172949.

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