Risk Score based on microRNA expression signature is
independent prognostic classifier of glioblastoma patients

J 2014

Risk Score based on microRNA expression signature is independent prognostic classifier of glioblastoma patients

ŠÁNA, Jiří, Lenka RADOVÁ, Radek LAKOMÝ, Leoš KŘEN, Pavel FADRUS et. al.

Základní údaje

Originální název

Risk Score based on microRNA expression signature is independent prognostic classifier of glioblastoma patients

Autoři

ŠÁNA, Jiří (203 Česká republika, domácí), Lenka RADOVÁ (203 Česká republika, domácí), Radek LAKOMÝ (203 Česká republika, domácí), Leoš KŘEN (203 Česká republika, domácí), Pavel FADRUS (203 Česká republika, domácí), Martin SMRČKA (203 Česká republika, domácí), Andrej BEŠŠE (703 Slovensko, domácí), Jana NEKVINDOVÁ (203 Česká republika), Markéta HERMANOVÁ (203 Česká republika, domácí), Radim JANČÁLEK (203 Česká republika, domácí), Marek SVOBODA (203 Česká republika, domácí), Marian HAJDÚCH (203 Česká republika), Pavel ŠLAMPA (203 Česká republika, domácí), Rostislav VYZULA (203 Česká republika, domácí) a Ondřej SLABÝ (203 Česká republika, garant, domácí)

Vydání

Carcinogenesis, Oxford, Oxford University Press, 2014, 0143-3334

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 5.334

Kód RIV

RIV/00216224:14740/14:00077330

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1093/carcin/bgu212

UT WoS

000345836200015

Klíčová slova česky

mikroRNA; expresní profilování; multiformní glioblastom; risc skóre; prognostický klasifikátor

Klíčová slova anglicky

microRNA; expression profiling; glioblastoma multiforme; risc score; prognostic classifier

Štítky

EL OK, kontrola MP, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 11. 3. 2015 13:26, Martina Prášilová

Anotace

V originále

Glioblastoma multiforme (GBM) is the most malignant primary brain tumor. The prognosis of GBM patients varies considerably and the histopathological examination is not sufficient for individual risk estimation. MicroRNAs (miRNAs) are small, non-coding RNAs that function as post-transcriptional regulators of gene expression and were repeatedly proved to play important roles in pathogenesis of GBM. In our study, we performed global miRNA expression profiling of 58 glioblastoma tissue samples obtained during surgical resections and 10 non-tumor brain tissues. The subsequent analysis revealed 28 significantly deregulated miRNAs in GBM tissue, which were able to precisely classify all examined samples. Correlation with clinical data led to identification of six-miRNA signature significantly associated with progression free survival [hazard ratio (HR) 1.98, 95% confidence interval (CI) 1.33-2.94, P < 0.001] and overa+ll survival (HR 2.86, 95% CI 1.91-4.29, P < 0.001). O(6)-methylguanine-DNA methyltransferase methylation status was evaluated as reference method and Risk Score based on six-miRNA signature indicated significant superiority in prediction of clinical outcome in GBM patients. Multivariate Cox analysis indicated that the Risk Score based on six-miRNA signature is an independent prognostic classifier of GBM patients. We suggest that the Risk Score presents promising prognostic algorithm with potential for individualized treatment decisions in clinical management of GBM patients.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

NT13514, projekt VaV

Název: Analýza mikroRNA v glioblastomových kmenových buňkách: predikce léčebné odpovědi a identifikace nových terapeutických cílů u pacientů s glioblastomem

Přiložené soubory

EL_1206178_Risk_Score.pdf

Požádat o autorskou verzi souboru

Citovat

ŠÁNA, Jiří, Lenka RADOVÁ, Radek LAKOMÝ, Leoš KŘEN, Pavel FADRUS, Martin SMRČKA, Andrej BEŠŠE, Jana NEKVINDOVÁ, Markéta HERMANOVÁ, Radim JANČÁLEK, Marek SVOBODA, Marian HAJDÚCH, Pavel ŠLAMPA, Rostislav VYZULA a Ondřej SLABÝ. Risk Score based on microRNA expression signature is independent prognostic classifier of glioblastoma patients. Carcinogenesis. Oxford: Oxford University Press, 2014, roč. 35, č. 12, s. 2756-2762. ISSN 0143-3334. Dostupné z: https://dx.doi.org/10.1093/carcin/bgu212.

@article{1206178,
   author = {Šána, Jiří and Radová, Lenka and Lakomý, Radek and Křen, Leoš and Fadrus, Pavel and Smrčka, Martin and Bešše, Andrej and Nekvindová, Jana and Hermanová, Markéta and Jančálek, Radim and Svoboda, Marek and Hajdúch, Marian and Šlampa, Pavel and Vyzula, Rostislav and Slabý, Ondřej},
   article_location = {Oxford},
   article_number = {12},
   doi = {http://dx.doi.org/10.1093/carcin/bgu212},
   keywords = {microRNA; expression profiling; glioblastoma multiforme; risc score; prognostic classifier},
   language = {eng},
   issn = {0143-3334},
   journal = {Carcinogenesis},
   title = {Risk Score based on microRNA expression signature is independent prognostic classifier of glioblastoma patients},
   volume = {35},
   year = {2014}
}

TY  - JOUR
ID  - 1206178
AU  - Šána, Jiří - Radová, Lenka - Lakomý, Radek - Křen, Leoš - Fadrus, Pavel - Smrčka, Martin - Bešše, Andrej - Nekvindová, Jana - Hermanová, Markéta - Jančálek, Radim - Svoboda, Marek - Hajdúch, Marian - Šlampa, Pavel - Vyzula, Rostislav - Slabý, Ondřej
PY  - 2014
TI  - Risk Score based on microRNA expression signature is independent prognostic classifier of glioblastoma patients
JF  - Carcinogenesis
VL  - 35
IS  - 12
SP  - 2756-2762
EP  - 2756-2762
PB  - Oxford University Press
SN  - 01433334
KW  - microRNA
KW  - expression profiling
KW  - glioblastoma multiforme
KW  - risc score
KW  - prognostic classifier
N2  - Glioblastoma multiforme (GBM) is the most malignant primary brain tumor. The prognosis of GBM patients varies considerably and the histopathological examination is not sufficient for individual risk estimation. MicroRNAs (miRNAs) are small, non-coding RNAs that function as post-transcriptional regulators of gene expression and were repeatedly proved to play important roles in pathogenesis of GBM. In our study, we performed global miRNA expression profiling of 58 glioblastoma tissue samples obtained during surgical resections and 10 non-tumor brain tissues. The subsequent analysis revealed 28 significantly deregulated miRNAs in GBM tissue, which were able to precisely classify all examined samples. Correlation with clinical data led to identification of six-miRNA signature significantly associated with progression free survival [hazard ratio (HR) 1.98, 95% confidence interval (CI) 1.33-2.94, P < 0.001] and overa+ll survival (HR 2.86, 95% CI 1.91-4.29, P < 0.001). O(6)-methylguanine-DNA methyltransferase methylation status was evaluated as reference method and Risk Score based on six-miRNA signature indicated significant superiority in prediction of clinical outcome in GBM patients. Multivariate Cox analysis indicated that the Risk Score based on six-miRNA signature is an independent prognostic classifier of GBM patients. We suggest that the Risk Score presents promising prognostic algorithm with potential for individualized treatment decisions in clinical management of GBM patients.
ER  -

ŠÁNA, Jiří, Lenka RADOVÁ, Radek LAKOMÝ, Leoš KŘEN, Pavel FADRUS, Martin SMRČKA, Andrej BEŠŠE, Jana NEKVINDOVÁ, Markéta HERMANOVÁ, Radim JANČÁLEK, Marek SVOBODA, Marian HAJDÚCH, Pavel ŠLAMPA, Rostislav VYZULA a Ondřej SLABÝ. Risk Score based on microRNA expression signature is independent prognostic classifier of glioblastoma patients. \textit{Carcinogenesis}. Oxford: Oxford University Press, 2014, roč.~35, č.~12, s.~2756-2762. ISSN~0143-3334. Dostupné z: https://dx.doi.org/10.1093/carcin/bgu212.

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